High producers

Germany which regularly consume more than they produce, are obviously of strong interest to the high producing, oversuppHed countries. Because wine is ... 

Minimum resistance to filtrate flow (i.e., high produc tion rate) Resistance to chemical attack... 

Uslaner J, Kalechstein A, Richter T, et al Association of depressive symptoms during abstinence with the subjective high produced by cocaine. Am J Psychiatry 156 1444-1446, 1999... 

Sarathchandra SU, Perrott KW, Boase MR, Waller JE (1988) Seasonal changes and the effects of fertilizer on some chemical, biochemical and microbiological characteristics of high-producing pastoral soil. Biol Fertil Soils 6 328-335... 

It seems probable from our discussion that individual normal males, for example, vary through wide limits (possibly 10-fold or more) in their production of both androgens and estrogens. If we classify individual men roughly as (1) low, (2) intermediate, and (3) high producers of each of the two types of hormones, we find that an... 

Based on a correlation of anthelmintic activity and HPLC analysis of the total avermectin complex, it was estimated that the third fermentation contained a minimum of 9 pg/ml. Improvement of the medium increased the yield by the original culture (MA-4680) to 120 yg/ml. A high-producing isolate (MA-4848) obtained from this culture produced nearly 500 pg/ml of total avermectins. Thus, this culture yielded readily to medium improvement and isolate selection to produce relatively large amounts of the avermectins. Accounts of the early fermentation studies and taxonomy have been published (1-2). 

Odakura et al. used a high producer derivative of M. olivasterospora MK-70 (DSM 43868), strain KYI 1250, to isolate 25 mutants blocked in at least 10 different steps of biosynthesis, as juged from complementation patterns in cosynthesis or biotransformation studies using vcy/to-inosose, cy/to-inosamine... 

In bright sunlight, the flux through the glycolate salvage pathway can be very high, producing about five times more C02 than is typically produced by all the ox-... 

Parallel with chemical investigations, microbiological studies were intensified, especially the search for high producing mutants, as well as the improvement of media and culture conditions to enhance yields. A substantial feedback resulted from examination of the biosynthesis of cyclosporins. Yields and the composition of the metabolite mixture were significantly influenced by exogenously supplied amino-acid precursors. 

The industrial production of 6-aminopenicillanic acid (6-APA), the key building block for all semisynthetic variations (1957) 6-APA is readily available from high-producing strains of Penidllium chrysogenum by enzymatic cleavage of penicillin G with penicillin acylase (see Section 2.03.11). 

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