Stem cells factors

Stellite tools Stelometer tester Stem cell factor... 

The potential for improved radioprotection by combining Tempol with growth factors such as stem cell factor (SGP), which protects by quite different mechanisms, has been examined in mice (82). Both SGP alone, given 20 and 4 h before and 4 h after TBI, and Tempol alone, given 10 min before TBI, increased 30-day survival, but protection was greater than additive when the two agents were combined. 

This seems plausible, as the time at which gonocytes become invasive coincides with periods during postnatal life and puberty when Sertoli cells are producing high amounts of hormones. The malignant gonocytes overexpress c-kit so it is possible that they might proliferate in response to stimulation by stem cell factor secreted by the Sertoli cells. ... 

Broudy VC (1997) Stem cell factor and hematopoiesis. Blood 90 1345-1364... 

Ray P. Krishnamoorthy N. Ray A Emerging functions of c-kit and its ligand stem cell factor in dendritic cells regulators of T cell differentiation. Cell Cycle 2008 7 2826-2832. 

Adding another layer of complexity to the regulation of mast cell activation levels in vivo is the observation that activated mast cells can respond to, and in some cases produce, a myriad of mediators that may serve to amplify FceRI-induced responses. For example, stem cell factor (SCF), the ligand for KIT, both can enhance FceRI-dependent activation of mouse or human mast cells and, under certain circumstances, can directly induce mast cell degranulation [6, 25, 62]. Thus, elevated SCF levels and/or activating KIT mutations (such as those that occur in mastocytosis) may exacerbate mast cell-driven reactions. Indeed, patients (both adult and children) with extensive skin disease associated with mastocytosis are at increased risk to develop severe anaphylaxis [63]. Moreover, it was recently reported that cases of idiopathic anaphylaxis are... 

Costa JJ, Demetri GD, Harris TJ. Dvorak AM. Hayes DF, Merica EA, Menchaca DM. Gringeri AJ. Schwartz LB, Galli SJ Recombinant human stem cell factor (kit ligand) promotes human mast cell and melanocyte hyperplasia and functional activation in vivo. J Exp Med 1996 183 2681-2686. 

Patella V, Marino I, Arbustini E. Lamparter-Schummert B, Verga L, Adt M. Marone G Stem cell factor in mast cells and increased mast cell density in idiopathic and ischemic cardiomyopathy. Circulation 1998 97 971. 

The most important survival and growth factor for mast cells is the KIT Ugand stem cell factor (SCF) [12], The hypothesis of early studies, that SCF might be elevated in skin lesions associated with mastocytosis [13], however, was not confirmed by later studies on SCF levels in skin and blood, at least for adult patients [14],... 

Okumura N, Tsuji K, Ebihara Y, et al. Chemotactic and chemokinetic activities of stem cell factor on murine hematopoietic progenitor cells. Blood 1996 87(10) 4100-4108. 

Yamamoto T, Hartmann K, Eckes B, Krieg T. Role of stem cell factor and monocyte chemoattractant protein-1 in the interaction between fibroblasts and mast cells in fibrosis. J Dermatol Sci 2001 26(2) 106-111. 

A variety of type 2 cytokines and the non-lymphoid cell-derived growth factor, stem cell factor (SCF) (Hiiltner et al., 1989 Copeland et al., 1990 Huang et al., 1990 Thompson-Snipes et al., 1991 reviewed in Befus, 1995), are known to be important in the development of intestinal mast cell responses associated with nematode infection but the contribution of this population to host protection depends on the nematode species in question. 

A critical role for stem cell factor and c-kit in host protective immunity to an intestinal helminth. International Immunology 8, 559-567. 

Puddington, L., Olson, S. and Lefrancois, L. (1994) Interactions between stem cell factor and c-kit are required for intestinal immune homeostasis. Immunity 1,... 

Donaldson, L.E., Schmitt, E., Huntley, J.F., Newlands, G.F. and Grencis, R.K. (1996) A critical role for stem cell factor and c-kit in host protective immunity to an intestinal helminth. International Immunology 8, 559-567. 

Duarte, R. and Frank, D. 2002. The synergy between stem cell factor (SCF) and granulocyte colony stimulating factor (G-CSF) molecular basis and clinical relevance. Leukaemia and Lymphoma 43(6), 1179-1187. 

Roferon IFN alfa-2a Stemgen (stem cell factor) Hoffman-La Roche Amgen... 

Growth factors, which are produced both as soluble and membrane-bound isotype proteins include members of the receptor tyrosine kinase subclass 111, such as stem cell factor (SCF) (Anderson et al, 1990 Huang et al, 1990), colony stimulating factor-1 (CSF-1, M-CSF) (Ladner et al, 1988 Ceretti et al, 1988) and Fit 3 ligand (Hannum et al, 1994 McClanahan et al, 1996). 

We used the stroma dependent Myl-D7 cell line to define unknown stem cell factors secreted by MSS stromal cells. CSF-1 was identified as a major growth factor component of the MSS supernatant by biochemical analysis. Recombinant CSF-1 induced short-term growth (3 days) of Myl-D7 to a similar extent as MSS CM. Furthermore, growth of the parental Myl-D7 clone in MSS CM could be inhibited by addition of an a-CSF-1 antibody, indicating that at least one of the active molecules is CSF-1. Thus we conclude that CSF-1 is a potent stimulator of the limited proliferation of the Myl-D7 stem cell line (Heberlein et al., 2006). 

Consistent with early observations we show here that CSF-1 can replace SCF as a stem cell factor in sustaining early cells and that CSF-1 is involved in... 

Itoh K, Friel J, Kluge N, Kina T, Kondo-Takaori A, Kawamata S, Uchiyama T, Ostertag W, 1996. A novel hemopoietic multi-lineage clone, Myl-D-7, is stromal cell dependent and supported by an alternative mechanism(s) independent of stem cell factor/c kit interaction. Blood 87 3218... 

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