Antioxidants lipid peroxidation inhibition

In vitro antioxidant, lipid peroxidation-inhibiting, and copper chelating activities were found from aqueous extracts of the leaves and roots. ... 

Probucol, another di-r-butyl phenol, is an anti-atherosclerotic agent that can suppress the oxidation of low-density lipoprotein (LDL) in addition to lowering cholesterol levels. The antioxidant activity of probucol was measured, using EPR, with oxidation of methyl linoleate that was encapsulated in liposomal membranes or dissolved in hexane. Probucol suppressed ffee-radical-mediated oxidation. Its antioxidant activity was 17-fold less than that of tocopherol. This difference was less in liposomes than in hexane solution. Probucol suppressed the oxidation of LDL as efficiently as tocopherol. This work implies that physical factors as well as chemical reactivity are important in determining overall lipid peroxidation inhibition activity (Gotoh et al., 1992). 

Broussochalcone A (32) Antioxidant activity (inhibition of lipid peroxidation) Inhibition of cyclooxygenase Inhibition of nitric oxide production Inhibition of respiratory burst in neutrophils Platelet aggregation inhibitory activity1 [42] [431 [42] [44] [431... 

Gneafricanins A, C-E and F (560, 562-565), longusol A (577) and bisisorhapontigenin B (518) all exhibited a considerable degree of activity in lipid peroxide inhibition and superoxide dismutases (SOD) like antioxidant activity [211]. Bisisorhapontigenins E-G and 13b-methoxy bisisorhapontigenin G (523-526) all possessed potent antioxidant activity compared with vitamin E [253]. 

Lliya I. et al. [54] found that many stilbenes showed potential antioxidant activities by comparing the antioxidant activities of nine compounds including monomers 2, 5, 6, dimmer 10, trimmers gnemonol B (70), I (71), K (72) and 20 with Vitamin E for lipid peroxide inhibition and super oxide scavenging activity [10]. 

SPs not only function as dietary fiber, but they also contribute to the antioxidant activity of marine algae. It has been demonstrated that SPs have potential antioxidant activity and various classes of SPs including fucoidan, laminaran, and alginic acid have been shown as potent antioxidants (Rocha de Souza et ah, 2007 Ruperez et ah, 2002 Wang et ah, 2008). Antioxidant activity of SPs have been determined by various methods such as l,l-diphenyl-2-picryl hydrazil (DPPH) radical scavenging, lipid peroxidation inhibition, ferric reducing antioxidant power (FRAP), nitric... 

Allspice oleoresin gave a positive result in the DNA-repair test but not in the Ames Salmonella reversion assay or the Bacillus subtilis rec assay (Sekizawa and Shibamoto 1982). Antimutagenicity via antioxidant activity of allspice was observed in the DPPH radical reduction assay and lipid peroxidation inhibition testing (Ramos et al. 2003). 

The antioxidant capacity of anthocyanins has been demonstrated by radical scavenging of reactive oxygen species, reducing capacity, inhibition, or delaying of lipoprotein oxidation and platelet aggregation. Anthocyanins as individual compounds or present in a more complex extract have been found to play a role in the prevention of cardiovascular diseases and to be involved in several different events like the prevention of DNA damage, estrogenic activity, enzymatic inhibition, anti-inflammation response, lipid peroxidation inhibition, etc. [3-7]. 

Experimentally, the substances were studied in vivo on rats at a dose equivalent to 10 mg/kg of the pharmacon per os. The total antioxidant activity of the blood plasma was assessed by a method based on the ability of the biological agents to inhibit the accumulation of lipid peroxidation products in a suspension of egg-yolk lipoproteins [44]. the maximum percentage of the lipid-peroxidation inhibition (in relation to the outcome) observed for nine hours of the experiment, served as an index of the antioxidant activity. 

Atalay et al. (2011) determined the lipid peroxidation inhibition potential for nine lichen compounds in two lipid peroxidation test systems (liposome and emulsion systems). They found that isidiophorin, rhizonaldehyde, rhizonyl alcohol and pulmonarianin retarded lipid peroxidation at in both test systems. However, stictic acid and ergosterol peroxide exhibited antioxidant activity in only the liposome test system. Usnic acid and diffractaic acid were not antioxidants in either system, while stictic acid was not lipid peroxidation inhibitor in the emulsion test system. All compounds, which inhibited lipid peroxidation in both test systems, were also DPPH radical scavengers. 

An infusion of the pods inhibited the in vitro proliferation of mouse hepatocellular tumor (Tl) cells and induced apoptosis in the cells. The crude polyphenol fraction of carob pods exhibits in vitro lipid peroxidation-inhibiting, antioxidant, and free radical scavenging activities. ... 

Alcoholic extracts of the roots and leaves of E. angustifolia, E. pallida, and E. purpurea exhibited comparable in vitro antioxidant activities in ABTS free radical scavenging assay, and the root extracts were also active in the lipid peroxidation inhibition assay.Methanolic extracts of freeze-dried roots of the three species act as in vitro antioxidants through the scavenging of DPPH and ABTS radicals, as well as by chelation of the copper ion (Cu Copper-catalyzed oxidation of human LDL was further demonstrated in vitro by different preparations from E. purpurea root containing alkamides, caffeoyl derivatives, and polysaccharides, as well as by pure caffeoyl derivatives. The antioxidant effect was synergistic and dose dependent. ... 

Other reported activities of P. cocos include antioxidant activity of the aqueous extract in different in vitro assays, such as lipid peroxidation inhibition and superanion sca-venging. °P. cocos triterepenes exhibited antiemetic activity in a leopard frog model of emesis. The ethanolic extract of P. cocos had an immunosuppressant effect resulting in suppressed rejection of heart transplants and prolonged survival in rats. ... 

C.G. Neochoritis, C.A. Tsoleridis, J. Stephanidou-Stephanataou, C.A. Kontogiorgis, D.J. Hadjipavlou-Litinia, 1,5-Benzoxazepines vs 1,5-ben-zodiazepines. One-pot microwave-assisted synthesis and evaluation for antioxidant activity and lipid peroxidation inhibition, J. Med. Chem. 53 (2010) 8409-8420. 

I, 5-benzodiazepines one-pot microwave-assisted synthesis and evaluation for antioxidant activity and lipid peroxidation inhibition,... 

Following the action of extraordinary stimulants (hypoxic hypoxia, hypoxia + hyperoxia, hypodynamia + hyperthermia), animals demonstrate an accumulation of malonic dialdehyde with a simultaneous fall of antiradical activity of the liver tissue. A preliminary introduction to rats of acetylene amine 3,4,5-tris(morpho-linopropynyl)-l-methylpyrazole 103 and also of tocopherol antioxidant and gutumine antihypoxant averts activation of the lipid peroxidation processes. The inhibition of peroxidation with this agent is mediated by stabilization of ly-zosomal and mitochondrial membranes. Unsaturated amines prevent destruction of the organelle membranes provoked by UV irradiation and incubation at 37°C (pH4.7)(78MIl). 

Kim, H.S. and Lee, B.M., Protective effects of antioxidant supplementation on plasma lipid peroxidation in smokers, J. Toxicol. Environ. Health A, 63, 583, 2001. Gaziano, J.M. et al.. Supplementation with beta-carotene in vivo and in vitro does not inhibit low density lipoprotein oxidation. Atherosclerosis, 112, 187, 1995. Sutherland, W.H.F. et al.. Supplementation with tomato juice increases plasma lycopene but does not alter susceptibility to oxidation of low-density lipoproteins from renal transplant recipients, Clin. Nephrol, 52, 30, 1999. 

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