Peroxidation inhibition

Probucol, another di-r-butyl phenol, is an anti-atherosclerotic agent that can suppress the oxidation of low-density lipoprotein (LDL) in addition to lowering cholesterol levels. The antioxidant activity of probucol was measured, using EPR, with oxidation of methyl linoleate that was encapsulated in liposomal membranes or dissolved in hexane. Probucol suppressed ffee-radical-mediated oxidation. Its antioxidant activity was 17-fold less than that of tocopherol. This difference was less in liposomes than in hexane solution. Probucol suppressed the oxidation of LDL as efficiently as tocopherol. This work implies that physical factors as well as chemical reactivity are important in determining overall lipid peroxidation inhibition activity (Gotoh et al., 1992). 

Oxidative ageing of rubbers is limited by the rate of diffusion of oxygen into the rubber product and is usually confined to the outer 3 mm. Antioxidants are used to protect rubbers from the effects of thermal oxidation and the vast majority of compounds will contain one or more. Peroxide vulcanisates are usually protected with dihydroquinolines. Other antioxidants react adversely with the peroxide inhibiting the crosslinking reaction. 

Broussochalcone A (32) Antioxidant activity (inhibition of lipid peroxidation) Inhibition of cyclooxygenase Inhibition of nitric oxide production Inhibition of respiratory burst in neutrophils Platelet aggregation inhibitory activity1 [42] [431 [42] [44] [431... 

Ray S, Sengupta C, Roy K. 2008. QSAR modeling for lipid peroxidation inhibition potential of flavonoids using topological and structural parameters. Cent Eur J Chem 6 267-276. 

Several members of the Cuparene class of sesquiterpenoids show interesting biological activity, including potent antifungal, neurotrophic and lipid peroxidation inhibition activity. Moreover, the presence of a hindered, quaternary... 

There is also evidence that the neuroprotective properties of lipid-peroxidation-inhibiting doses of methylprednisolone, extensively studied in spinal-cord injury, are applicable to brain injury. The steroid has been shown to enhance the early recovery of mice subjected to a moderately severe concussive head injury when administered at 5 minutes post-injury [59], The dose-response curve for this effect is remarkably similar to that discussed above for spinal-cord injury. A 30mg/kg i.v. dose was observed to be optimal, while lower (15 mg/kg) and higher (60 and 120 mg/kg) doses were ineffective. 

Gneafricanins A, C-E and F (560, 562-565), longusol A (577) and bisisorhapontigenin B (518) all exhibited a considerable degree of activity in lipid peroxide inhibition and superoxide dismutases (SOD) like antioxidant activity [211]. Bisisorhapontigenins E-G and 13b-methoxy bisisorhapontigenin G (523-526) all possessed potent antioxidant activity compared with vitamin E [253]. 

Mitochondrial effects GSH depletion ATP depletion Phospholipid modifications Heat shock protein modifications Lipid peroxidation Inhibition of membrane potential Ca release into cytosol... 

Lliya I. et al. [54] found that many stilbenes showed potential antioxidant activities by comparing the antioxidant activities of nine compounds including monomers 2, 5, 6, dimmer 10, trimmers gnemonol B (70), I (71), K (72) and 20 with Vitamin E for lipid peroxide inhibition and super oxide scavenging activity [10]. 

Compounds Super oxide scavenging actmty[lC >(uM)l Lipid peroxide inhibition activityriCsn(uM)l DPPH radical [SC, (pM)]... 

Cmpd Ri r2 r3 Lipid peroxidation inhibition IC50 (jiM) DPPH scavenging IC50 (pM) ABTS4 TEAC scavenging ... 

The reported commercial catalysts for monochloroacetic acid are acetic anhydride or acetyl chloride with hydrogen chloride phosphorus, probably entering the reaction as a phosphite acetate ester and acetic anhydride or acetyl chloride with an ionic peroxide inhibiting catalyst such as chromium. acetate or manganese acetate. ... 

Many types of liver injury are caused by a number of biochemical reactions of toxicants or their active metabolites. Such reactions inclnde covalent binding, lipid peroxidation, inhibition of protein synthesis, pertnrbation of calcium homeostasis, disturbance of biliary prodnction, and a variety of immunologic reactions. The types of liver injury from such biochemical reactions include steatosis (fatty liver), liver necrosis, cirrhosis, cholestasis, hepatitis, and carcinogenesis. The toxicants that cause these injuries are discussed in brief. 

SPs not only function as dietary fiber, but they also contribute to the antioxidant activity of marine algae. It has been demonstrated that SPs have potential antioxidant activity and various classes of SPs including fucoidan, laminaran, and alginic acid have been shown as potent antioxidants (Rocha de Souza et ah, 2007 Ruperez et ah, 2002 Wang et ah, 2008). Antioxidant activity of SPs have been determined by various methods such as l,l-diphenyl-2-picryl hydrazil (DPPH) radical scavenging, lipid peroxidation inhibition, ferric reducing antioxidant power (FRAP), nitric... 

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