Anti-inflammation

For an appreciation in clinical and commercial terms, see Boehncke, W.-H. Current Opinion Anti-Inflamm. Immtmo-... 

Huang S-T, Liao J-S, Fang H-W, Lin C-M (2008) Synthesis and anti-inflammation evaluation of new C60 fulleropyrrolidines bearing biologically active xanthine. Bioorg. Med. Chem. Lett. 

Adenosine 2a receptor ADORA2A Agonism Inhibition of platelet aggregation, anti-inflammation and neuroprotective effects, coronary vasodilation, decreased blood pressure, increased plasma renin activity and sleep induction. Antagonism Increased platelet aggregation, hypertension, nervousness (tremor, agitation), arousal, insomnia, cerebral and coronary vasodilation (in microvessels only). 

Anti-inflammation, immunosuppression, corticosteroid replacement therapy PO 0 6-... 

Juncus effusus L. Deng Xin Cao (Common rush) (whole plant) Tripeptide, r-glutamyl-valyl-glutamic acid, apigenin, juglandic acid, juglonone, barium, luteolin-7-glucoside, luteolinidin, oxalic acid, arsenic, vitamins.48 450 Diuretic, sexually transmitted diseases, anti-inflammation. 

Pedicularis resupinata L. P. resupinata L. f. pubescens Kom. P. resupinata L. f. ramosa Kom. Ma Xian Gao (Lousewort) (whole plant) Alpha-amyrin, beta-amyrin, betulinic acid, cholesterol, kaempferol.50-218 Used in fever, leucorrhea, rheumatism, sterility, urinary difficulties, anti-inflammation, dryness of the mouth, tongue, and tinnitus. 

N.A. Balsaminones, 2-methoxy-l, 4-naphthoquinone, saponins, quercitin, kaempferol derivatives, balsaminasterol, parinaric acid, hosenkosides.302 Remedy for rashes, pain caused by insect bites, anti-inflammation. 

N.A. Corylus avellana L. C. comuta Marsh. C. rostrata Marsh. C. americana Marsh. Tannins, essential oil, ferric oxide, beta-sitosterol.102 For coughs, colds, diuretic, prostaglandin inhibition, anti-inflammation. 

The FDA approves Vioxx, an anti-inflammation drug for treatment of osteoarthritis and some other conditions that cause acute pain. 

Actinobacteria Amino acid, Anti-inflammation, Schneemann et al. 

Classically, inflammation is a protective reaction of the body in response to some physical, chemical, or microbial injury and insult of the cells. Acute inflammation, rapid onset and shorter duration, is considered as a healthy response. However, when inflammation continues for prolonged period of time, it becomes detrimental and may raise the first step of a chronic disease (Medzhitov, 2008). Arachidonic acid/COX and nuclear factor- (NF- ) are well known inflammatory pathways which induce production of inflammatory mediators such as prostaglandins, thromboxanes, leukotrienes, and cytokines. Most commonly accepted mechanism of anti-inflammation is inhibition of cyclooxygenase (COX) activity. There are two kinds of cyclooxygenases COX-1 is natural protective enzyme of intestinal mucosa while COX-2 is induced by tissue damage as an inflammatory mediator (Maroon et al., 2006). NF- is a recently identified... 

Whatever the mechanism of action for the inhibition of 5-lipoxygenase by flavonoids, it appears to be distinct from the antioxidant properties of these compounds. The results comparing antioxidant activity with leukotriene inhibitory activity clearly demonstrate this distinction. The profound effects of metabolic transformation on the anti-inflammation activity of dietary flavonoids such as quercetin must also be considered in relation to in vitro studies, and further highlights the need to use actual metabolic forms of flavonoids rather than the free aglycone or glycosides occurring in the diet. 

Serhan C. N. (2005a). Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution. Prostaglandins Leukot. Essent. Fatty Acids 73 141-162. 

Serhan C. N. (2005b). Novel m-3-derived local mediators in anti-inflammation and resolution. Pharmacol. Ther. 105 7-21. 

Drug Naproxen (Naprosyn) Analgesia 500 mg initially 250 mg every 6-8 hr Anti-inflammation 250, 375, or 500 mg BID... 

Hong, S., Gronert, K., Devchand, P.R., Moussignac, R.L.. and Serhan, C.N., Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation, J. Biol. Chem., 278, 14677, 2003. 

Assay for Anti-inflammation and Anti-allergic Compounds... 

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