Inhibition of nitric oxide production

Chronic inhibition of nitric oxide production augments skin vasoconstriction in the rabbit ear. J. Cardiovasc. Pharmacol. 22, 290-296. 

Waksman Y, Olson SM, Carlisle SJ, Cabral, GA. The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells. J Pharmacol Exp Ther 1999 288 1357-1366. 

Broussochalcone A (32) Antioxidant activity (inhibition of lipid peroxidation) Inhibition of cyclooxygenase Inhibition of nitric oxide production Inhibition of respiratory burst in neutrophils Platelet aggregation inhibitory activity1 [42] [431 [42] [44] [431... 

Cayatte AJ, Palacino JJ, Horten K, Cohen RA. 1994. Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits. Arterioscler Thromb Vase Biol 14 753-759. 

Mabuchi T, Matsumura S, Okuda-Ashitaka E, Kitano T, Kojima H, Nagano T, Minami T, Ito S (2003) Attenuation of neuropathic pain by the nociceptin/orphanin FQ antagonist JTC-801 is mediated by inhibition of nitric oxide production. Eur J Neurosci 17 1384-1392 Mabuchi T, Shintani N, Matsumura S, Okuda-Ashitaka E, Hashimoto H, Muratani T, Minami T, Baba A, Ito S (2004) Pituitary adenylate cyclase-activating polypeptide is required for the development of spinal sensitization and induction of neuropathic pain. J Neurosci 24 7283-7291... 

Two further perspectives on the use of tetracychnes in rheumatoid arthritis have been pubhshed (14,15). In addition to an effect on matrix metalloproteinases, the authors focused on a potential antiarthritic action of tetracyclines by their effects in the interaction between the generation of nitric oxide, matrix metalloproteinase release, and chondrocyte apoptosis. Both minocychne and doxycycline inhibit the production of nitric oxide from human cartilage and murine macrophages (16) in concentrations that are achieved in vivo. The authors suggested that tetracyclines may have several potential chondroprotective effects direct inhibition of matrix metalloproteinase activity and, by inhibition of nitric oxide production, further reduction of matrix metalloproteinase activity, reversal of reduced matrix synthesis, and reduced chondrocyte apoptosis. 

Ross, R.A., Brockie, H.C, and Pertwee, R.G. (2000). Inhibition of nitric oxide production in RAW264.7 macrophages by cannabinoids and palmitoylethanolamine. European Journal of Pharmacology, 401 121-130. 

Harput, U.S., I. Saracoglu, and Y. Ogihara. 2005. Stimulation of lymphocyte proliferation and inhibition of nitric oxide production by aqueous Urtica dioica extract. Phytother. Res. 19(4) 346-348. 

Physalin A, B, F, I, O, Y and Z Inhibition of nitric oxide production in lipopolysaccharide-activated macrophages [107, 117]... 

Tseng et al. (2005) have used different benzothiazolium compoxmds (142 143) to study their activity for the inhibition of nitric oxide production in a cell culture system They found that benzothiazolium salts have been the better inhibitors than N-methyl arginine (L-NMMA) a known inhibitor. They have demonstrated these results by the correlation of in vivo and in vitro activities using mouse paw edema (Tseng et al. 2005). 

Figure 2, Inhibition of nitric oxide production from RA W 264.7 by HMP. RA W 264.7 cells were treated with LPS (0.5 pg/mL) either alone or with different concentrations (25 pM-6.25 pM) of HMP for 24 hrs and supernatant were collectedfrom each treatment group. The amount of nitrite was measured using Griess reagent. Each bar represents mean standard deviation (SD) of 4 replicates of one representative experiment of total five experiments. Represents statistical significance of inhibition of LPS stimulated NO production by HMP as compared to LPS alone ( p<0.05 p<0.01).

Yamamoto, T., Terada, N., Seiyama, A., Nishizawa, Y., Akedo, H., and Kosaka, H. (1998). Increase in experimental pnhnonary metastasis in mice by L-aiginine under inhibition of nitric oxide production by NG-nitro-L-arginine methyl ester. Int. J. Cancer 75(1), 140-144. 

Kurose, I., Kubes, P., Wolf, R., Anderson, D.C., Paulson, J., Miyasaka, M., and Granger, D.N. (1993). Inhibition of nitric oxide production, mechanisms of vascular albumin leakage. Circ. Res. 73, 164-171. 

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