Tumors hepatocellular

In the chronic inhalation bioassay of 1,2-dibromoethane conducted by NTP (1982) (discussed in Section 2.2.1.8), increased incidence of focal and centrilobular hepatocellular necrosis occurred in male and female F344 rats exposed to the highest dose (40 ppm) of 1,2-dibromoethane. Compound-related degenerative or necrotizing hepatocellular lesions did not occur in B6C3Fi mice following exposure to any concentration used. Liver lesions were not reported in rats after chronic inhalation exposure to 20 ppm 1,2-dibromoethane with or without 0.05% disulfiram in the diet however, hepatocellular tumors (not otherwise classified) were induced in exposed rats fed dietary disulfiram (Wong et al. 1982). Also see Section 2.2.1.8. 

Toxicology. Aldrin is a convulsant in animals it causes liver and kidney damage and hepatocellular tumors. 

Toxicology. Chlorodibromomethane is a central nervous system (CNS) depressant at extremely high concentrations it is toxic to the liver and kidneys of rodents and induces hepatocellular tumors in mice after long-term exposure. 

In 2-year chronic studies, DEHP caused a significant increase in hepatocellular carcinomas in female rats fed diets containing 12,000ppm, in male mice ingesting 6000ppm, and in female mice ingesting 3000 or 6000 ppm. Hepatocellular tumors were confirmed in a number of other oral assays in rats and mice. ... 

Administered to mice for 80 weeks, lindane caused a significant increase in hepatocellular tumors in low-dose males but not in other groups of mice or in rats. Use of lindane by... 

Carcinogenesis Carbamazepine administered to rats for 2 years at doses of 25 to 250 mg/kg/day resulted in a dose-related increase in the incidence of hepatocellular tumors in females and benign interstitial cell adenomas in the testes of males. Pregnancy Category D. 

In the NTP (1986) study, male mice had marginally increased incidences of hepatocellular tumors and mesenchymal tumors of the integumentary system at 500 mg/kg/day and of malignant lymphomas at 250 mg/kg/day. NTP (1986) considered this evidence to be equivocal because the study showed marginal increases in neoplasms related to isophorone exposure. The doses of 250 and 500 mg/kg/day are indicated in Table 2-2 and Figure 2-2 as CELs for carcinogenicity in mice. There was no evidence of carcinogenicity in female rats or mice. 

Danazol is a weak androgen and also has a series of other hormonal and anti-hormonal properties. It inhibits pituitary gonadotropin and has been used in the treatment of endometriosis, fibrocystic disease of the breast, idiopathic thrombocytopenic purpura, and hereditary angioedema. Its hepatotoxic effects include reversible rises in serum transaminases and cholestatic hepatitis a few cases of hepatocellular tumors have been reported. 

A 37-year-old woman with refractory idiopathic thrombocytopenic purpura, who had responded dramatically to danazol 600 mg/day after the failure of other forms of treatment, developed a multinodular well-differentiated trabeculovesicular hepatocellular tumor after 5 years. There were no metastases and no invasion of the lymph nodes, and after chemoembolization she received an orthoptic liver transplant. A year later she remained in good condition. 

J. K.T., Noz, M.E. Hepatocellular tumors characterization with Mn-DPDP-enhanced MR imaging. Radiology 1993 188 53-59... 

Vecchio, F.M. Fibrolamellar carcinoma of the liver a distinct entity within the hepatocellular tumors. A review. Appl. Pathol. 1988 6 139-148... 

Table 13 Sensitivity to liver tumor development and H-ras codon 61 mutations in spontaneous hepatocellular tumors of various strains of mice...

There was an increased incidence of lymphoma in grafted macaques and male mice also receiving cyclosporine. Rats exposed to cyclosporine A developed renal and hepatocellular tumors. 

An exposure-related increase in the incidence of hepatocellular tumors was observed in female mice exposed to unleaded gasoline vapors for 2 years (MacFarland et al. 1984). Some of these tumors metastasized to the lungs. 

Cooke, J.B. and D.E. Hinton. Promotion by 17 beta-estradiol and beta-hexachlorocyclohexane of hepatocellular tumors in medaka, Oryzias latipes. Aquat. Toxicol. 45 127-145, 1999. 

CARCINOEMBRYONIC ANTIGEN A canalicular staining pattern for polyclonal carcinoembryonic antigen (pCEA) is seen in 60% to 90% of HCCs O600 (pjg 1530) and is useful in discriminating hepatocellular tumors from other malignancies. E586 However, it should be remembered that abortive lumina formation in poorly differentiated adenocarcinomas can mimic canalicular pattern. 

Wang XY, Degos E, Dubois S, et al. Glypican-3 expression in hepatocellular tumors diagnostic value for preneoplastic lesions and hepatocellular carcinomas. Hum Pathol. 2006 37 1435-1441. 

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