Lipid peroxidation inhibitor

Py rrolostatin is a novel lipid peroxidation inhibitor, which is isolated from Sirepinmyces diresinmyceiiois. Its stnicnire consists of a pyrrole-3-carboxyiic acid v/ith a geranyl group at the 4-posidon. It is readily prepared by applying the Barton-Zard pyrrole synthesis, as shown inEq. 10.33. ... 

Hall, E.D., Pazara, K.E. and Braughler, M.J. (1988). 21-Aminosteroid lipid peroxidation inhibitor U74006F protects against cerebral ischemia in gerbils. Stroke 19, 997-1002. 

Many amino- and hydroxy-substituted heterocycles have reasonably low oxidation potentials and, as such, can act as lipid-peroxidation inhibitors. We have already discussed triaminopyrimidine examples (tirilazad and U78517) and several ascorbic-acid analogues. This section discusses a few more examples. 

Kato, S., Shindo, K., Kawai, H., Odagawa, A., Matsuoka, M. and Mochizuki, J. (1993). Pyrrolostatin, a novel lipid peroxidation inhibitor. J. Antibiot. 892-898. 

Strasburg GA, Nair MG Jayaprakasam B. (2004) Potent lipid peroxidation inhibitors from withania somnifera fruits. Tetrahedron 60 3109-3121. 

Fig. 2. Chemical structures of lipid peroxidation inhibitors shown to be protective in models of brain...

Another antioxidant mechanism of action is the inhibition of the lipid peroxidation. It can be detected by different methods, but, in most of them, the peroxidation is induced by F enton reaction, in which hydroxyl radicals are generated. Therefore, it would be logical to think that those PPGs that have shown hydroxyl radical scavenging, will be active as lipid peroxidation inhibitors. But it is necessary to develop these kind of assays, because, the absorption properties of these compounds into cells or the ways in which they may offer protection to the exterior of the cell wall, still remain unknown [35]. 

Uses Antioxidant in cosmetics whitening agent for skin lightening creams collagen synthesis promoter lipid peroxidation inhibitor... 

Jayapiakasam B, Strasburg GA, Nmr MG (2004) Potent lipid peroxidation inhibitors from Withania somnifera fruits. Tetrahedron 60 3109-3121 Johnston JFW (1840) Philos Trans Roy Soc, London A 341 fide Noda et al. (1990)... 

Atalay et al. (2011) determined the lipid peroxidation inhibition potential for nine lichen compounds in two lipid peroxidation test systems (liposome and emulsion systems). They found that isidiophorin, rhizonaldehyde, rhizonyl alcohol and pulmonarianin retarded lipid peroxidation at in both test systems. However, stictic acid and ergosterol peroxide exhibited antioxidant activity in only the liposome test system. Usnic acid and diffractaic acid were not antioxidants in either system, while stictic acid was not lipid peroxidation inhibitor in the emulsion test system. All compounds, which inhibited lipid peroxidation in both test systems, were also DPPH radical scavengers. 

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