Allergic reaction adverse skin

Adverse effects. Paracetamol is usually well-tolerated by the stomach because inhibition of prostaglandin synthesis in the periphery is weak allergic reactions and skin rash sometimes occur. Heavy, long-term daily use may predispose to chronic renal disease. 

Adverse reactions to digoxin include anorexia, vomiting, diarrhea, dizziness, headaches, visual disturbances, and cardiac arrhythmias. Allergic reaction such as urticaria, skin emptions, fever, and edema have been reported (87). 

The most common adverse reactions seen with administration of the cephalosporins are gastrointestinal disturbances, such as nausea, vomiting, and diarrhea Hypersensitivity (allergic) reactions may occur with administration of the cephalosporins and range from mild to life threatening. Mild hypersensitivity reactions include pruritus, urticaria, and skin rashes. More serious hypersensitivity reactions include S teveils-Johnson syndrome (fever, cough, muscular aches and... 

Bleeding is the most common adverse reaction seen with the use of these drugp. Bleeding may be internal and involve areas such as die GI tract, genitourinary tract, and die brain. Bleeding may also be external (superficial) and may be seen at areas of broken skin, such as venipuncture sites and recent surgical wounds. Allergic reactions may also be seen. 

Iron salts occasionally cause gastrointestinal irritation, nausea, vomiting, constipation, diarrhea, headache, backache, and allergic reactions. The stools usually appear darker (black). Iron dextran is given by the parenteral route Hypersensitivity reactions, including fatal anaphylactic reactions, have been reported with the use of this form of iron. Additional adverse reactions include soreness, inflammation, and sterile abscesses at the intramuscular (IM) injection site Intravenous (IV) administration may result in phlebitis at the injection site When iron is administered via the IM route, a brownish discoloration of tlie skin may occur. Fhtients with rheumatoid arthritis may experience an acute exacerbation of joint pain, and swelling may occur when iron dextran is administered. 

Topical antiseptics and germicides have few adverse reactions. Occasionally, an individual may be allergic to die drug, and a skin rash or itching may occur. If an allergic reaction is noted, use of the topical drug is discontinued. 

Every patient receiving antimicrobial therapy for skin and soft tissue infections must be monitored for efficacy and safety. Efficacy typically is manifested by reductions in temperature, white blood cell count, erythema, edema, and pain that begin within 48 to 72 hours. To ensure safety, dose antibiotics according to renal and hepatic function as appropriate, and monitor for and minimize adverse drug reactions, allergic reactions, and drug interactions. 

For idiosyncratic, patient related adverse reactions, less confirmatory tests are available but the number is growing. Skin, blood and urine tests are available to confirm acute and chronic allergic reactions. Genetic tests can determine the susceptibility of individuals and includes general tests such as for the porphyrias and sickle cell anaemia, and specific tests for dmg metabolism, such as acetylator status... 

Apart from possible symptoms of hypoglycemia adverse effects include lipohypertrophy from repeated injections in the same subcutaneous area and localized allergic skin reactions as well as generalized allergic reactions. 

Fluorouracil is a pyrimidine analogue (see Chapter 27, Section II.b.3). Topical application may be used for malignant and premalignant skin conditions, including actinic keratosis. Adverse effects include local inflammatory and allergic reactions. Photosensitivity reactions during and for up to 2 months after treatment may become manifest. 

The most common adverse health effect of nickel in humans is an allergic reaction to nickel. People can become sensitive to nickel when jewelry or other things containing nickel are in direct contact with the skin. Wearing earrings containing nickel in pierced ears may also sensitize people to nickel. Once a person is sensitized to nickel, further contact with the metal will produce a reaction. The most common reaction is a skin rash at the site of contact. In... 

Adverse effects include G1 upset, dose related impairment of taste, thrombocytopenia, aplastic anemia, allergic reactions, skin rash, fever, SLE and proteinuria. 

Adverse effects include nausea, vomiting, allergic reactions, fever, anaphylaxis, skin rash, Raynaud s phenomenon, stomatitis, pulmonary fibrosis, hyperpigmentation, renal and hepatic toxicity. 

All loop diuretics, with the exception of ethacrynic acid, are sulfonamides. Therefore, skin rash, eosinophilia, and less often, interstitial nephritis are occasional adverse effects of these drugs. This toxicity usually resolves rapidly after drug withdrawal. Allergic reactions are much less common with ethacrynic acid. 

The term iodism covers a group of adverse effects that include irritation of the skin, the mucous membranes, and the conjunctiva. Allergic reactions are rare and... 

Several clinical trails are reported with curcumin in cancer patients around the world. Some of our recent review [Anand et al., 2008 Goel et al., 2007 Kunnumakkara et al., 2008] gives a detailed description of the clinical trials with curcumin, which are summarized in Table 16.2. An early clinical trial evaluated the effectiveness of topical application of a curcumin ointment in patients with external cancerous lesions. Patients with cancers of oral cavity (37 patients), breast (7 patients), vulva (4 patients), skin (3 patients), and miscellaneous unspecified sites (11 patients) were enrolled in this study. Remarkable symptomatic relief was observed in this study with the reduction in smell in 90% of the cases, reduction in itching in almost all cases, and reduction in exudates in 70% of cases. Reduction in lesion size and pain was observed in about 10% of the cases and only one melanoma (scalp) patient showed an adverse effect of local itching, which may be due to the allergic reaction to curcumin. 

Adverse Side Effects. Leflunomide s primary side effects include gastrointestinal distress, allergic reactions (skin rashes), and hair loss.57 This drug can also affect the liver liver function may need to be monitored periodically.19,70... 

Adverse Effects. When administered directly into the bladder, common side effects include bladder irritation and infection. Systemic administration (immunization) may also cause dermatologic reactions (peeling or scaling of the skin), allergic reactions, inflammation of lymph nodes, and local irritation or ulceration at the injection site. 

Indinavir sulfate is a protease inhibitor and is used in combinations for the treatment of viral infection. During the high risk of HIV infection, indinavir is combined with zidovudine and lamivudine.65 Indinavir sulfate should be used with caution in patients with hepatic impairment and avoided in patients with severe liver damage. Caution is needed in diabetic patients and in patients with hemophilia. Adverse effects of indinavir sulfate include nausea, vomiting, diarrhea, fatigue, dizziness, headache, skin rashes, and allergic reactions (hematuria). 

Adverse effects The most common of these are headache, diarrhea, and nausea. Other untoward effects are weight loss, allergic reactions including a flu-like syndrome, skin rash, alopecia, and hypokalemia. Leflunomide is teratogenic in experimental animals, and is therefore contraindicated in pregnancy, and in women of childbearing potential. It should be used with caution in patients with liver disease, because it is cleared by both biliary and renal excretion. Cholestyramine increases the clearance of leflunomide. 

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