Infection soft-tissue

These antibiotics are effective in die treatment of infections caused by a wide range of gram-negative and gram-positive microorganisms. The tetracyclines are used in infections caused by Rickettsiae (Rocky Mountain spotted fever, typhus fever, and tick fevers). Tetracyclines are also used in situations in which penicillin is contraindicated, in the treatment of intestinal amebiasis, and in some skin and soft tissue infections. Oral... 

Pharmacological factors 3.4 Skin and soft tissue infections... 

However, local anesthetics may be helpful when abrasion accompanies the injury.39 Application of an over-the-counter antibiotic ointment containing an anesthetic may provide soothing relief, promote healing of abrasions, and prevent soft-tissue infection. Minor abrasions should be cleansed thoroughly with mild soap and water before application. More severe abrasions may require removal of debris or foreign bodies by a clinician followed by irrigation with normal saline. 

Describe the epidemiology, etiology, pathogenesis, clinical manifestations, diagnostic criteria, and complications associated with skin and soft tissue infections. 

Every patient receiving antimicrobial therapy for skin and soft tissue infections must be monitored for efficacy and safety. Efficacy typically is manifested by reductions in temperature, white blood cell count, erythema, edema, and pain that begin within 48 to 72 hours. To ensure safety, dose antibiotics according to renal and hepatic function as appropriate, and monitor for and minimize adverse drug reactions, allergic reactions, and drug interactions. 

Another important necrotizing skin and soft tissue infection is clostridial myonecrosis (gas gangrene). Clostridial myonecrosis can develop spontaneously but most often occurs after trauma. Clostridium perfringens is the most common causative pathogen. 

Spreading soft tissue infection and osteomyelitis are often the first complications that develop from diabetic foot infection. Some patients develop bacteremia and sepsis. 

Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections. Clin Infect Dis 2005 41 1373-1406. 

Without Vascular Insufficiency Adult (greater 50 years) Postoperative (e.g., hip fractures), soft-tissue infections 5. aureus Nafci 11 i n or cefazolin... 

Necrotizing fasciitis A severe soft-tissue infection involving the... 

Chap. 70 - Skin and Soft Tissue Infections Universal Program Number ... 

Although used as a simulant, it can cause acute bacterial meningitis, pneumonia, intraabdominal infections, enteric infections, urinary tract infections, septic arthritis, endophthalmitis, suppurative thyroiditis, sinusitis, osteomyelitis, endocarditis, and skin and soft tissue infections. There are also strains of E. coli (C17-A015) that produce lethal cytotoxins (C16-A052). ... 

Only for soft-tissue infections or upper respiratory infections (pharyngitis, otitis media). 

The conditions that may predispose a patient to the development of skin and soft-tissue infections (SSTIs) include (1) a high concentration of bacteria, (2) excessive moisture of the skin, (3) inadequate blood supply, (4) availability of bacterial nutrients, and (5) damage to the corneal layer allowing for bacterial penetration. 

Evidence-Based Recommendations for Treatment of Skin and Soft-Tissue Infections... 

Treatment of soft-tissue infections in diabetic patients should generally be at least 7 to 14 days in duration, although some infections may require an additional 1 to 2 weeks of therapy. However, in cases of underlying osteomyelitis, treatment should continue for 6 to 12 weeks. 

See Chap. 114, Skin and Soft-Tissue Infections, authored by Douglas N. Fish, Susan L. Pendland, and Larry H. Danzinger, for a more detailed discussion of this topic. 

---