Toxicity materials

The third of the major hazards and the one with the greatest disaster potential is the release of toxic chemicals. The hazard posed by toxic release depends not only on the chemical species but also on the conditions of exposure. The high disaster potential from toxic release arises in situations where large numbers of people are briefly exposed to high concentrations of toxic material, i.e., acute exposure. However, the long-term health risks associated with prolonged exposure at low concentrations, i.e., chronic exposure, also present serious hazards. 

In preliminary process design, the primary consideration is contact by inhalation. This happens either through accidental release of toxic material to the atmosphere or the fugitive emissions caused by slow leakage from pipe flanges, valve glands, and pump and compressor seals. Tank filling causes emissions when the rise in liquid level causes vapor in the tank to be released to the atmosphere. 

The use of an unnecessarily hot utility or heating medium should be avoided. This may have been a major factor that led to the runaway reaction at Seveso in Italy in 1976, which released toxic material over a wide area. The reactor was liquid phase and operated in a stirred tank (Fig. 9.3). It was left containing an uncompleted batch at around 160 C, well below the temperature at which a runaway reaction could start. The temperature required for a runaway reaction was around 230 C. ... 

The major hazard from the release of flammable or toxic material... 

On the other hand, if the hazard is toxicity, process alternatives can be compared by assessing the mass of toxic material that would enter the vapor phase on release from containment, weighting the components according to their lethal concentration. 

The effects of pollution can be direct, such as toxic emissions providing a fatal dose of toxicant to fish, animal life, and even human beings. The effects also can be indirect. Toxic materials which are nonbiodegradable, such as waste from the manufacture of insecticides and pesticides, if released to the environment, are absorbed by bacteria and enter the food chain. These compounds can remain in the environment for long periods of time, slowly being concentrated at each stage in the food chain until ultimately they prove fatal, generally to predators at the top of the food chain such as fish or birds. 

Influence of the chemical composition of fuels on emissions of toxic materials (auto/oil program). 

M. Sittig, ed.. Pesticide Manufacturing and Toxic Materials ControlEngclopedia, Noyes Data Corp., Park Ridge, N.J., 1980. 

Acrolein is a highly toxic material with extreme lacrimatory properties. At room temperature acrolein is a Hquid with volatiUty and flammabiUty somewhat similar to acetone but unlike acetone, its solubiUty in water is limited. Commercially, acrolein is always stored with hydroquinone and acetic acid as inhibitors. Special care in handling is required because of the flammabiUty, reactivity, and toxicity of acrolein. 

Treatment of Industrial Effluents. Solvent extraction appears to have great potential in the field of efduent treatment, both for the economic recovery of valuable materials and for the removal of toxic materials to comply with environmental requirements. 

Cobalt difluoride, used primarily for the manufacture of cobalt trifluoride, CoF, is available from Advance Research Chemicals, Inc., Aldrich Chemicals, and PCR in the United States, Fluorochem in the UK, and Schuhardt in Germany. The 1993 price varied from 60 to 200/kg depending on the quantity and the price of cobalt metal. C0F2 is shipped as a corrosive and toxic material in DOT-approved containers. 

Mycotoxins. The condition produced by the consumption of moldy foods containing toxic material is referred to as mycotoxicosis. Molds and fungi fall iato this category and several derive thek toxicity from the production of oxaflc acid, although the majority of mycotoxias are much more complex. 

This extremely toxic material is an intermediate in the synthesis of nitnlotriacetic acid (NTA), EDTA, and glycine [56-40-6]. 

Substitution of less toxic materials for asbestos (qv) is the most common control. 

Many filters in chemical process units are either changed very rarely or are back-flushed automatically so there is hardly any exposure. Some filters, however, require frequent manual changing or cleaning and significant exposure may occur unless operators foUow the proper procedure. The filter container should be drained of any toxic material and then flushed and purged as needed so that when it is opened there is only minimal exposure. Zero exposure is difficult to achieve in situations where a disposable paper filter cartridge may retain and slowly release a material that cannot be removed by multiple flushes and purges. 

Toxic substances adsorbed on resins are removed during a regeneration procedure. The resulting spent regeneration solution has a higher concentration of the toxic substance than the stream from which it was removed by the resin. Toxic material in the spent regenerating solution can usually be precipitated, electrodeposited as in an electrolytic ceU, or made insoluble by other acceptable procedures. 

The State of New Jersey has passed a law restricting the sale and disposal of batteries (qv) containing mercury, requiring manufacturers to reduce the mercury content of each battery to 1 ppm by weight by 1995, and to estabhsh a collection program for spent batteries (14). Another New Jersey law bans the sale of products having cadmium, mercury, or other toxic materials in the packaging (14) (see Cadmiumand cadmium alloys Cadmium compounds Mercury compounds). 

Dmg metaboHsm may also produce toxic materials. Thus, the aromatic hydroxylation of hydrocarbons such as ben2pyrene produces the highly reactive and carcinogenic 1,2-epoxides. 

Pigments contribute to the enjoyment and beauty of the world. To assure the future of inorganic pigments, research efforts are directed toward the development of environmentally acceptable pigments, pigments that when produced under weU-controUed conditions do not release any toxic materials into the environment whether during production, use, or disposal. 

Clean Air Act and its amendments ia 1970, 1977, and 1990 1967 Air Quahty Standards and National Air Pollution Acts and 1970 National Environmental PoHcy Act) (2) better waste disposal practices (1965 SoHd Waste Disposal Act 1976 Resource Conservation and Recovery Act) (see Wastes, industrial Waste treatment, hazardous wastes) (i) reduced noise levels (1972 Noise Control Act) (4) improved control of the manufacture and use of toxic materials (1976 Toxic Substances Control Act) and (5) assignment of responsibiUty to manufacturers for product safety (1972 Consumer Product Safety Act) (15,16). 

A California statue requiring ha2ardous materials management was passed in 1985 (24), but guidance for compliance for industries covered by the act was not issued until 1988 (25). A revised standard, which became effective in January of 1994 (26), appHes to faciUties handling any of 128 toxic materials flammable Hquids and gases in quantities of 10,000 lb (4.54 t) or more, except where used as fuel or in atmospheric pressure, ambient temperature tanks and explosives. 

This recommended practice is intended to apply to faciUties that (/) handle or store flammable or explosive substances in such a manner that a release of ca 5 t of gas or vapor could occur in a few minutes and (2) handle toxic substances. The threshold quantity for the toxic materials would be determined using engineering judgment and dispersion modeling, based on a potential for serious danger as a result of exposures of <1 h. 

Safety Showers. Safety showers and eyewash fountains or hoses should be installed where corrosive or toxic materials are handled. A large-volume, low velocity discharge from directly overhead should effect continuous drenching, ie, a minimum flow of 20 L/min (50 gal /min). Water to outside showers may be heated to a maximum temperature of 27°C by an electric heating cable. The valves for all safety showers should be at the same height and relative position to the shower head, and they should operate in the same way and direction. The shower station should be identified by paint of a bright, contrasting color. In areas where chemicals harmful to the eyes may be encountered, an eyewash fountain or spray should be available in case of splash accidents. 

Eor toxic materials, it usually is advisable to provide ventilated sampling hoods or breathing-air stations and masks, to assure that the sampler is adequately protected from toxic or flammable vapors and dusts. Special provision for access to and exit from sampling points also may be needed at elevated locations and to avoid tripping or bumping ha2ards and to ensure that the sampler does not transverse areas not intended as walkways, eg, tank covers or roofs. 

Health and Safety Factors. Animal-feeding studies of DMPPO itself have shown it to be nontoxic on ingestion. The solvents, catalyst, and monomers that are used to prepare the polymers, however, should be handled with caution. Eor example, for the preparation of DMPPO, the amines used as part of the catalyst are flammable toxic on ingestion, absorption, and inhalation and are also severe skin and respiratory irritants (see Amines). Toluene, a solvent for DMPPO, is not a highly toxic material in inhalation testing the TLV (71) is set at 375 mg/m, and the lowest toxic concentration is reported to be 100—200 ppm (72). Toxicity of 2,6-dimethylphenol is typical of alkylphenols (qv), eg, for mice, the acute dermal toxicity is LD q, 4000 mg/kg, whereas the acute oral toxicity is LD q, 980 mg/kg (73). The Noryl blends of DMPPO and polystyrene have PDA approval for reuse food apphcations. 

Screw Feeders. Screws are primarily used when feed over a slotted outlet is requited. Screws are a good choice when an enclosed feeder is requited, when space is restricted, when handling dusty or toxic materials, or when attrition (particle breakage) is not a problem. A screw is composed of a series of flights that are wound around a common shaft. The flights have a particular diameter and pitch (the distance between flights). Some screws have constant pitch flights others vary. The screw shaft has to be sized to prevent deflection (12). 

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