Toxic Substance Act

Phase I and phase II reactions are obviously important in mitigating the effects of toxic sustances. Some toxic substances act by inhibiting the enzymes that carry out phase I and phase... 

Other legislation that may impact upon therapeutic products includes the Contraception, Sterilisation and Abortion Act 1977, the Toxic Substances Act 1979, the Toxic Substances Regulations 1983 and the Dietary Supplements Regulations 1983. 

Exposure limits are set by the Health and Safety Commission, on the advice of its Advisory Committee on Toxic Substances (ACTS) and Woridng Group on the Assessment of Toxic Chemicals (WATCH). ACTS has begun publishing the full rationale for establishing exposure limits as Criteria Documents . The format of these documents is modelled on that adopted by the EC [17]. 

The 1979 Toxic Substances Act and the 1983 Toxic Substances Regulations require new toxic substances to be notified before manufacture or import. The information required is only the name, composition and uses, although more can be requested. The definition... 

United Kingdom Department of Work and Pensions Health and Safety Commission/Health and Safety Executive Advisory Committee on Toxic Substances (ACTS) Health and Safety Executive... 

Toxic, corrosive, and radioactive materials were under the control of the Ministry of Health. Toxics and corrosives were controlled by the Toxic Substances Act and Regulations, while radioactive materials came under the Radiation Protection Act and Regulations. 

There are three types of TAP emissions continuous, intermittent, and accidental. Both routine emissions associated with a batch process or a continuous process that is operated only occasionally can be intermittent sources. A dramatic example of an accidental emission was the release of methyl isocyanate [624-83-9] in Bhopal, India. As a result of this accident, the U.S. Congress created Tide III, a free-standing statute included in the Superfund Amendments and Reauthorization Act (SARA) of 1986. Title III provides a mechanism by which the pubHc can be informed of the existence, quantities, and releases of toxic substances, and requires the states to develop plans to respond to accidental releases of these substances. Eurther, it requires anyone releasing specific toxic chemicals above a certain threshold amount to aimuaHy submit a toxic chemical release form to EPA. At present, there are 308 specific chemicals subject to Title III regulation (37). 

Table 5. Grignard Reagents Listed on the U.S. EPA Toxic Substances Control Act (TSCA) List...

The importance of hydrolysis potential, ie, whether moisture or water is present, is illustrated by the following example. In the normal dermal toxicity test, namely dry product on dry animal skin, sodium borohydride was found to be nontoxic under the classification of the Federal Hazardous Substances Act. Furthermore, it was not a skin sensitizer. But on moist skin, severe irritation and bums resulted. 

The latest government regulations set forth under the Toxic Substances Control Act and in PubHc Health Service pubHcations should be checked before formulating new lubricants. Users of lubricants should request Material Safety Data Sheets for each substance involved plus certification of compliance from vendors. Lubricant compounders should insist on similar information from their suppHers for any additive packages. Manufacturers of both additives and lubricants commonly make toxicity checks on commercial products. 

Toxic Substances Control Act, Public Law No. 469, 94th U.S. Congress Chemical Substance Inventory, U.S. Environmental Protection Agency, Office of Toxic Substances, Wasliiagton, D.C., 1975. 

Clean Air Act and its amendments ia 1970, 1977, and 1990 1967 Air Quahty Standards and National Air Pollution Acts and 1970 National Environmental PoHcy Act) (2) better waste disposal practices (1965 SoHd Waste Disposal Act 1976 Resource Conservation and Recovery Act) (see Wastes, industrial Waste treatment, hazardous wastes) (i) reduced noise levels (1972 Noise Control Act) (4) improved control of the manufacture and use of toxic materials (1976 Toxic Substances Control Act) and (5) assignment of responsibiUty to manufacturers for product safety (1972 Consumer Product Safety Act) (15,16). 

In Delaware, the Regulation for the Management of Extremely Ha2ardous Substances Act, developed in response to the Bhopal disaster and several chemical-release incidents in Delaware, became effective in 1989 (27,28). The regulations Hst 88 toxic substances, 32 flammable substances, and 50 explosive substances. A sufficient quantity is specified for each of these materials, based on potential for a catastrophic event at a distance of 100 m from a potential source of a 1-h release. 

Information on health and safety considerations cited herein for Ryton PPS powders and pellets can be found in Reference 157. Ryton PPS [26125-40-6] is listed in the Toxic Substance Control Act (TSCA) Inventory of Chemicals. 

All the PMBs are Hsted on the U.S. EPA s Toxic Substances Control Act NonConfidential Chemical Substances Inventory (Table 8). In the early to mid-1980s, pseudocumene, mesitylene, hemimellitene, and trimethylbenzene were coveted by TSCA Section 8(a) Preliminary Assessment Information Rule (PAIR) reporting requirements (22) and by TSCA Section 8(d) for health and safety data (23). Mesitylene is the subject of a test rule subacute oral toxicity and subchtonic oral toxicity in tats were underway in 1994 (24). The Safe Drinking Water Act (SDWA) allows monitoring for pseudocumene and mesitylene at the discretion of the State (25). Of the PMBs, only pseudocumene is subject to SARA Tide III section 313 annual release reporting (26). 

The two main federal agencies involved in the protection of human health and the environment are the Environmental Protection Agency (EPA) and the Occupational Safety and Health Administration (OSHA). EPA s principal concern is the protection of the environment, in most cases, the area outside of an industrial faciUty. There are 10 regional offices that carry out the regulatory functions of the agency (Table 1). Primary laws covered by EPA are the Clean Air Act Amendments (CAAA), the Clean Water Act (CWA), Resource Conservation and Recovery Act (RCRA), Comprehensive Environmental Response, Compensation, and LiabiUty Act (CERCLA), Toxic Substances Control Act (TSCA), and Eederal Insecticide, Eungicide, and Rodenticide Act (FIFRA). 

Toxic Substances Control Act. EPA regulates the manufacture, use, and exposure to ha2ardous or toxic chemicals under a number of laws. Eor the chemical industry, the law of prime concern is the Toxic Substance Control Act (TSCA) (10), which was passed by the U.S. Congress in 1976. The two main goals of TSCA are acquisition of sufficient information to identify and evaluate potential ha2ards from chemical substances, and regulation of the production, use, distribution, and disposal of these substances. 

Toxic Substances Control Act, Chemical Substances Inventory further information can be obtained from Industry Assistance Office, Pesticides and Toxic Substances, Environmental Protection Agency, Washington, D.C. 

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