Federal Hazardous Substance Act

The importance of hydrolysis potential, ie, whether moisture or water is present, is illustrated by the following example. In the normal dermal toxicity test, namely dry product on dry animal skin, sodium borohydride was found to be nontoxic under the classification of the Federal Hazardous Substances Act. Furthermore, it was not a skin sensitizer. But on moist skin, severe irritation and bums resulted. 

Code of Federal Regulations, Title 16, part 1500, Federal Hazardous Substances Act Regulation, Consumer Products Safety Commission, Washington,... 

As a part of the Federal Hazardous Substances Act (FHSA), a modified Draize test was adopted [63-65] as the official method for evaluation of acute ocular irritancy [66]. It is a pass/fail determination that remains in effect today. Two refinements have been accepted as alternatives (a) the test which uses a small volume more consistent with the capacity of the inferior con-... 

To help protect small children, CPSC requires that the concentration of lead in most paints available through normal consumer channels be not more than 0.06%. The Federal Hazardous Substance Act (FHSA) bans children s products containing hazardous amounts of lead. 

Federal Hazardous Substances Act CPSC Household products Risk... 

The CPSC staff performed quantitative risk assessments on various flame-retardants for both upholstered residential furniture fabrics and foam.89 CPSC addresses chemical hazards under the Federal Hazardous Substances Act (FHSA), which is risk based. For fabrics, five flame-retardants were evaluated, that include antimony trioxide, deca-BDE, HBCD, phosphonic acid, (3- [hydroxymethyl]amino)-3-oxopropyl)-, dimethyl ester (PA), and tetrakis (hydroxymethyl) phosphonium chloride (THPC). These flame-retardants were selected for study because they are used to comply with the U.K. upholstered furniture flammability standard (except THPC) and fabric samples were available for testing. The staff concluded in 2006 that deca-BDE, HBCD, and PA would not present a hazard to consumers and that additional data would be needed to assess antimony trioxide and THPC. 

All Draize-type tests evaluate corrosion and irritation by using albino rabbits as subjects (Table 3). The Federal Hazardous Substance Act (FHSA) adopted one modification as a standard procedure to this method (1997). 

DOT- Department of Transportation FHSA - Federal Hazardous Substance Act FIFRA - Federal Insecticide, Fungicide, and Rodenticide Act OECD - Organization for Economic Cooperation and Development. 

Consumer Products. The Consumer Product Safety Commission s (CPSC) labeling criteria under the Federal Hazardous Substances Act are based on biological testing. In the absence of specific data, CPSC requires specific cautionary statements for consumer products containing certain types and amounts of sodium siUcates (87). 

US Consumer Product Safety Commission. 2001. Code of Federal Regulations, Subchapter C -Federal Hazardous Substances Act Regulations, 16, Part 1500. 

Note. FHSA, Federal Hazard Substance Act NAS, National Academy of Sciences OECD, Organization for Economic Cooperation and Development IRLG, Interagency Liaison Group. Tests should be conducted on monkeys when confirmatory data are required. 

To carry out its mission, CPSC administers five statutes. They are (1) the Consumer Product Safety Act (CPSA), (2) the Federal Hazardous Substances Act (FHSA), (3) the Flammable Fabrics Act (FFA), (4) the Poison Prevention Packaging Act (PPPA), and (5) the Refrigerator Safety Act (RSA). Toxicological issues arise most frequently under the CPSA, FHSA, and PPPA. CPSC regulations implementing these statutes may be found at Title 16 of the Code of Federal Regulations (CFR) and are available on the Commission s website. 

US Consumer Product Safety Commission (CPSC) (1992) Labeling requirements for art materials presenting chronic hazards guidelines for determining chronic toxicity of products subject to the FHSA supplementary definition of toxic under the Federal Hazardous Substances Act final rules. Federal Register 57 46626—46674 (1992). 

U.S. Federal Hazardous Substances Act. 16 CFR 1500, www.cpsc.gov/busi-nessinfo/fhsa.html... 

The primary hazard of commercial soluble silicates is their moderate-to-strong alkalinity. Contact—exposure effects can range from irritation to corrosion, depending on the concentration of the silicate solution, the silica-to-alkali ratio, the sensitivity of the tissue exposed, and the duration of exposure. Sodium silicate solutions of commercial concentrations having a m < 1.8 and silicate powders of m < 2.4 attack the skin when tested according to Federal Hazardous Substances Act (FHSA) protocols (93). Soluble silicates are rapidly absorbed and eliminated if ingested or inhaled (94,95). Trace quantities of silicon are essential in nutrition, possibly as a metal ion bio availability attenuator (96), but siliceous urinary calculi may result if normal dietary amounts are gready exceeded (79). 

Title 16—Commercial Practices (This title includes Consumer Product Safety Regulations, such as the Federal Hazardous Substances Act, which are important to labeling considerations for chemical products)... 

For the chronic studies required by some Federal regulations, the species specified by the agencies are used, usually rats and beagle dogs. Under the Federal Hazardous Substance Act ( ) for example, the definitions of toxic, highly toxic, and non-toxic... 

Following administration of the doses, observations are made of the animals for peiods ranging from a few minutes to two weeks, to comply with the requirements of some regulations e.g. the Federal Hazardous Substances Act. The lethality is determined on the basis of death occuring within the observation period (14 days) ... 

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