Targeting of Liposomes

Leserman, L., and Machy, P. (1987) Ligand targeting of liposomes. In Liposomes From Biophysics to Therapeutics (M.J. Ostro, ed.), pp. 157-194. Dekker, New York. 

Martin, F.J., Hubbell, W., and Papahyadjopoulos, D. (1981) Immunospecific targeting of liposomes to cells a novel and efficient method for covalent attachment of Fab fragments via disulfide bonds. Biochemistry 20, 4229-4238. 

Singhal, A., and Gupta, C.M. (1986) Antibody-mediated targeting of liposomes to red cells in vivo. FEES Lett. 201, 321. 

S. M. Stephenson, P. S. Low, and R. J. Lee. Folate receptor-mediated targeting of liposomal drugs to cancer cells. Methods Enzymol. 387 33-50 (2004). 

Littau VC, Allfrey VG, Frenster JH, Mirsky AE (1964) Active and inactive regions of nuclear chromatin as revealed by electron microscope autoradiography. Proc Natl Acad Sci USA 52 93-100 Longmuir KJ, Robertson RT, Haynes SM, Baratta JL, Waring AJ (2006) Effective targeting of liposomes to liver and hepatocytes in vivo by incorporation of a Plasmodium amino acid sequence. Pharm Res 23 759-769... 

Table 1 Requirements to Achieve Therapeutically Efficacious Passive Targeting of Liposomes Loaded with Drugs and Their Solution...

Main requirements to achieve therapeutically efficacious passive targeting of liposomes... 

Schott H, et al. Antibody cell-targeting of liposomes carrying ara-C derivatives. Nucleosides Nucleotides 1988 7 721. 

Hdlig P, et al. Novel RGD lipopeptides for the targeting of liposomes to integrin-expressing endothelial and melanoma cells. Protein Eng 2004 17 433. 

Sinha J, Mukhopadhyay S, Das N, Basu MK. (2000) Targeting of liposomal andrographolide to L. donovani-infected macrophages in vivo. Drug Deliv 7 209-213. 

Active Targeting of Liposomes Based on Ligand-Receptor Interactions... 

Schreier, H., P. Moran, and I.W. Caras, Targeting of liposomes to cells expressing CD4 using glycosylphosphatidylinositol-anchored gpl20. Influence of liposome composition on intracellular trafficking. J Biol Chem, 1994. 269(12) 9090-8. 

Slepushkin, V.A., Salem, II, S.M. Andreev, P. Dazin, and N. Duzgunes, Targeting of liposomes to HIV-1-infected cells by peptides derived from the CD4 receptor. Biochem Biophys Res Commun, 1996. 227(3) 827-33. 

Rosenberg, M.B., X.O. Breakefield, and E. Hawrot, Targeting of liposomes to cells bearing nerve growth factor receptors mediated by biotinylated nerve growth factor. J Neurochem, 1987. 48(3) 865-75. 

Duffels, A., Green, L.G., Ley, S.V. and Miller, A.D. (2000) Synthesis of high-mannose type neoglycolipids Active targeting of liposomes to macrophages in gene therapy. Chem. Eur. J., 6,1416-1430. 

Meers, P. Enzyme-activated targeting of liposomes. Adv. Drug Deliv. Rev. 53(3) 265-272. 2001. 

Lee, R. J., and Low, P. S. Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro. Biochim. Biophys. Acta 1233 134-44, 1995. 

R. Gonzales-Rothi, S. Suarez, G. Hochhaus, H. Schreier, A. Lukyanov, H. Derendorf, and T. Dalla Costa, Pulmonary targeting of liposomal triamcinolone acetonide phosphate, Pharm. Res. 13 1699 (1996). 

J. A. A. M. Kamps, H. W. M. Morselt, P. J. Swart, D. K. F. Meijer, and G. L. Scherphof, Massive targeting of liposomes, surface-modified with anionized albumins, to hepatic endothelial cells, Proc. Natl. Acad. Sci. USA 94 11681-11685, (1997). 

Gonzalez-Rothi, R. J., Suarez, S., Hochhaus, G., Schreier, H., Lukyanov, A., Derendorf, H., and Dallas Costa, T. (1996), Pulmonary targeting of liposomal triamcinolone aceton-ide, Pharm. Res., 13,1699-1703. 

Gabizon, A., Price, D. C., Huberty, I, Bresalier, R. S., and Papahadjopoulos, D. (1990), Effect of liposome composition and other factors on the targeting of liposomes to experimental tumors Biodistribution and imaging studies, Cancer Res., 50, 6371-6378. 

Gabizon, A., Shmeeda, H., Horowitz, A.T., and Zalipsky, S. (2004),Tumor cell targeting of liposome-entrapped drugs with phosphohpid-anchored folic acid-PEG conjugates, Adv. Drug Deliv. Rev., 56,1177-1192. 

Bernstein, N. Antibody-directed targeting of liposomes to human cell lines role of binding and internalization on growth inhibition. Cancer Res. 1987, 47, 5954—5959. 

Small pegylated liposomes have been shown to extravasate into tumors with leaky vasculature, and the prolonged circulation half-life has a positive effect on the extravasation. Passive tumor targeting of liposomes was visualized in a study of radio-labeled PEG-liposomes in patients with locally advanced cancers, and whole body gamma camera imaging was used to monitor biodistribution and tumor localization. Of 17 patients treated with In-DTPA (Diethylenetri-aminepentaacetic acid) labeled PEG-liposomes, tumor... 

Torchilin, V.P. Fluorescence microscopy to follow the targeting of liposomes and micelles to cells and their intracellular fate. Adv. Drug Del. Rev. 2005, 57 (1), 95-109. 

Kato Y, Watanabe K, Hosokawa T, et al. Modification of liposomes by addition of HCO60. I. Targeting of liposomes to liver by addition of HCO60 to liposomes. Biol Pharm Bull 1993 16 960-964. 

An interesting example of intracellular targeting of liposomes was described recently, when liposomes containing in their membrane composition mitochonriotropic amphiphilic cation with delocalized positive charge were shown to specifically target mitochondria in inact cells (153). The liposomes were deemed mitochondriotropic due to inclusion of lipidic analogues of triphenylphosphonium cations, which facilitates the efficient subcellular delivery of proapototic ceramide to mitochondria of mammalian cells and improves its activity in vitro and in vivo (154). 

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