HIV-1 infected H9 cells

They are generally active at the two steps of the integration but are not selective for IN and the practical utility of those catechol-containing inhibitors is severely reduced by cytotoxicity even though they have been found to inhibit HIV-1 integrase in vitro. Nevertheless, lithospermic acids, Fig. (19) were found to be active on purified IN as well as on HIV-1 infected H9 cells, and showed no cytotoxicity to H9 cells [80]. 

Fig. 2. Selective toxicity of EF13 for C8166 cells chronically infected with HIV-1. Uninfected (H9) and chronically HIV-infected (H9RF) cells were cultured for 4 d in the presence of EF13, a potential anti-HIV compound. Cell samples were taken daily and counted in the presence of Trypan blue to determine the proportion of cells that were live and dead. The data points represent the mean of 5 counts plus error bars of one standard deviation.

Briggs CJ, Ott DE, Coren LV, Oroszlan S, Tozser J. Comparison of the effect of FK506 and cyclosporin A on vims production in H9 cells chronically and newly infected by HIV-1. Arch Virol 144(11) 2151-2160, 1999. 

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