Liposomes targeted

Straubinger, R. M., Lopez, N. G., Debs, R. J., Hong, K., and Papahadjopoulos, D. (1988). Liposome-based therapy of human ovarian cancer Parameters determining potency of negatively charged and antibody-targeted liposomes, Cancer Res.. 48, 5237-5245. 

Target-Sensitive Liposomes. For targeting liposomes to a specific site, antibody-coated liposomes or ligand-coated liposomes are usually used. Target-sensitive liposomes composed of PE and palmitoyl-antibody have been developed these are destabilized on binding to the target and release the contents at the specific site (46)... 

External stimuli have also been used to further target liposomes. In one such study magnetite particles were incorporated in radiolabeled liposomes and a magnet positioned over the right kidney of a test animal. The liposomes were selectively targeted to that kidney in concentrations that were viewed as significantly high for relevant clinical applications [66],... 

Heath, T.D., Montgomery, J.A., Piper, J.R., and Papahadjopoulos, D. (1983) Antibody-targeted liposomes Increase in specific toxicity of methotrexate-g-aspartate. Proc. Natl Acad. Sci. USA 80, 1377-1381. 

Jansons, V.K., and Mallet, P.L. (1980) Targeted liposomes A method for preparation and analysis. Anal. Biochem. Ill, 54-59. 

Noble CA, Kirpotin DB, Hayes ME, et al. Development of ligand-targeted liposomes for cancer therapy. Expert Opin Ther Targets 2004 8 335-353. 

Goren D, Horowitz AT, Tzemach D, Tarshish M, Zalipsky S, Gabizon A. Nuclear delivery of doxorubicin via folate-targeted liposomes with bypass of multidrug-resistance efflux pump. Clin Cancer Res 2000 6 1949-1957. 

Forssen E, Willis M. Ligand-targeted liposomes. Adv Drug Deliver Rev 1998 29 249. 

Sapra P, Allen TM. Ligand-targeted liposomal anticancer drugs. Prog Lipid Res 2003 42 439. 

Medina OP, Zhu Y, Kairemo K. Targeted liposomal drug delivery in cancer. Curr Pharm Design 2004 10 2981. 

Gregoriadis G. Engineering targeted liposomes progress and problems. Trends Biotechnol 1995 13 527-537. 

A synthetic peptide has been designed to mimic the effects of viral fusogenic properties (114,115). It consists of 30 amino acids with the major repeat of Glu-Ala-Leu-Ala so, it is referred to as a GALA peptide. It undergoes a conversion from an aperiodic conformation at neutral pH and becomes an amphipathic alpha helix at pH 5. In the more acidic environment, the peptide interacts with lipid bilayers (114,115). GALA has been incorporated into transferrin-targeted liposome, with the effect of significantly... 

Figure 1.1. Schematic representation of four major liposome types. Conventional liposomes are either neutral or negatively charged. Stealth liposomes are sterically stabilized and carry a polymer coating to obtain a prolonged circulation time in the body. Immunoliposomes are antibody targeted liposomes and can consist of either conventional or sterically stabilized liposomes. Positive charge on cationic liposomes can be created in various ways. Reproduced from reference [112] with permission.

Finally, covalent bonding between phospholipids incorporated in liposomal vesicles and various proteins has been explored and may provide an avenue for future development of the concept and design of targeting liposomes. 

Phospholipid Passive drug targeting, liposomes Lung surfactant... 

Sapra, P. and Allen, T. M. (2003). Ligand-targeted liposomal anticancer cflrag. Lipid Res., 42, 439-462. 

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