Glycosylphosphatidylinositol anchored

Antony, A. C., and Miller, M. E. (1994). Statistical prediction of the locus of endoproteo-lytic cleavage of the nascent polypeptide in glycosylphosphatidylinositol-anchored proteins. Biochem. J. 298, 9-16. 

Udenfriend, S., and Kodukula, K. (1995a). How glycosylphosphatidylinositol-anchored membrane proteins are made. Annu. Rev. Biochem. 64, 563—591. 

To better understand the structural properties of the lipoproteins involved in intracellular signaling pathways, synthetic lipopeptides are required as model compounds. In this context, to bypass the enzyme-catalyzed lipidation occurring in nature, optimized synthetic procedures have been elaborated for the more simple lipo-derivatives (for comprehensive reviews see ref[1]). However, similar efficient synthetic procedures for the glycosylphosphatidylinositol anchor are still lacked. 

Schreier, H., P. Moran, and I.W. Caras, Targeting of liposomes to cells expressing CD4 using glycosylphosphatidylinositol-anchored gpl20. Influence of liposome composition on intracellular trafficking. J Biol Chem, 1994. 269(12) 9090-8. 

Stevens, V. L. and Tang, J. (1997). Fumonisin Bl-induced sphingolipid depletion inhibits vitamin uptake via the glycosylphosphatidylinositol-anchored folate receptor. ]. Biol. Chem. 272(29), 18020-18025. 

Watanabe, R., Funato, K., Venkataraman, K., Futerman, A. H., and Riezman, H. (2002). Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast. J. Biol. Chem. 277(51), 49538—49544. 

Kukulansky T, Abramovitch S, Hollander N. Cleavage of the glycosylphosphatidylinositol anchor affects the reactivity of thy-1 with antibodies. J Immunol 1999 162(10) 5993 5997. 

Gillmor, C. S., Lukowitz, W., Brininstool, G., Sedbrook, J. C., Hamann, T., et al., Glycosylphosphatidylinositol-anchored proteins are required for cell wall synthesis and morphogenesis in arabidopsis. Plant Cell 2005, 17 (4), 1128-1140. 

Patel, B. N., and David, S. (1997). A novel glycosylphosphatidylinositol-anchored form of ceruloplasmin is expressed by mammalian astrocytes./. Biol. Chem. 272, 20185-20190. 

Low, M.G., 2000, Glycosylphosphatidylinositol-anchored proteins and their phospholipases. In Cockcroft, S. (ed.), Frontiers in Molecular Biology, Vol. 27, Biology of Phosphoinositides. Oxford University Press, New York, pp. 211-238. 

Sharom, F.J., and Lehto, M.T., 2002, Glycosylphosphatidylinositol-anchored proteins Structure, function, and cleavage by phosphatidylinositol-specific phospholipase C. Biochem. Cell. Biol. 80 535-549. 

Fig. 3.10 A protein anchored to the membrane with a glycosylphosphatidylinositol anchor.

Komano, H., Rockwell, N., Wang, G.T, Krafft, G.A., Puller, R.S. (1999). Purification and characterization of the yeast glycosylphosphatidylinositol-anchored, monobasic-specific aspartyl protease yapsin 2 (Mkc7p). J. Biol. Chem., 271, 24421-24437. 

Examples of receptors and ligands involved in RME. Specific gene symbols of representative human receptor and ligand proteins are listed in parentheses. TM transmembrane protein GPI glycosylphosphatidylinositol anchored protein 7TM Seven-transmembrane protein. 

Peyron P, Bordier C, N Diaye EN et al. Nonopsonic phagocytosis of Mycobacterium kansasii by human neutrophils depends on cholesterol and is mediated by CR3 associated with glycosylphosphatidylinositol-anchored proteins.) Immunol 2000 165(9) 5186-5191. 

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