Leukemia adult T-cell

Lymphomas not included in Working Formulation mycosis fungoides, mantle cell lymphoma, monocytoid B-cell lymphoma, mucosa-associated lymphoid tissue (MALT), anaplastic large cell lymphoma, angiocentric lymphoma, angioimmunoblastic lymphadenopathy (AILD), Castleman s disease, adult T-cell leukemia/lymphoma. 

Ishida T, Iida S, Akatsuka Y, et al. The CC chemokine receptor 4 as a novel specific molecular target for immunotherapy in adult T-cell leukemia/lymphoma. Clin Cancer Res 2004 10 7529-7539. 

Adult T-cell leukemia Human T-cell Retrovirus RNA... 

HTLV I Endemic in W Indies and SW Japan transmission via blood, human milk can cause adult T-cell leukemia, and HTLV I-associated myelopathy and tropical spastic paraparesis... 

MM = multiple myeloma ATL = adult T-cell leukemia ALL = acute lymphoblastic leukemia CLL = chronic lymphocytic leukemia FCC = follicular center cell lymphoma DLC = diffuse large cell lymphoma TRB = T-cell rich B-cell lymphoma ALCL = anaplastic large cell lymphoma MALT = mucosa-associated lymphoid tissue-type lymphoma LC = lung cancer CMM = cutaneous malignant melanoma TCC = transitional cell carcinoma CSCC = cutaneous squamous cell carcinoma. 

K3. Kinoshita, K., Kamihira, S., Yamada, Y, Amagasaki, T., Ikeda, S., Momita, S., and Ichimaru, M., Adult T-cell leukemia-lymphoma in the Nagasaki district. In Adult T-Cell Leukemia and Related Disease (M. Hanaoka, K. Takatsuki, and M. Shimoyama, eds.), pp. 167-184. Japan Scientific Societies Press, Tokyo, 1982. 

Shimoyama, M., Diagnostic criteria and classification of clinical subtypes of adult T-cell leukemia-lymphoma. A report from the Lymphoma Study Group (1984-87). Br. J. Haematol. 79,428-437 (1991). 

T2. Tamiya, S., Ftoh, K., Suzushima, H., Takatsuki, K., and Matsuoka, M., Mutation of CD95 (Fas/Apo-1) gene in adult T-cell leukemia cells. Blood 91, 3935-3942 (1998). 

Kasai T, Iwanaga Y, Iha H et al. Prevalent loss of mitotic spindle checkpoint in adult T-cell leukemia confers resistance to microtubule inhibitors. JBiol Chem 2002 277 5187-5193. 

Tomita M, Kawakami H, Uchihara JN, Okudaira T, Masuda M, Takasu N, Matsuda T, Ohta T, Tanaka Y, Ohshiro K, Mori N. 2006. Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells. Int J Cancer 118 765-772. 

T/NK (natural killer) cell lymphomas are much less common in Western countries and much less understood than the B cell lymphomas. Thus, the discussion of these entities will be much briefer. In addition, a significant number of the T/NK lymphomas, such as enteropathy-type T cell lymphoma, hepatosplenic T cell lymphoma, subcutaneous panniculitis-like T cell lymphoma, blastic NK cell lymphoma, T cell granular lymphocytic leukemia, and adult T cell leukemia/ lymphoma, will not be discussed in this review. The reader is advised to consult the recent World Health Organization Classification of Tumours (J2). 

Ohira, A., Honda, O., Gauntt, C.D., Yamamoto, M., Hori, K., Masutani, H., Yodoi, J., and Honda, Y. 1994. Oxidative stress induces adult T cell leukemia derived factor/thioredoxin in the rat retina. Lab. Invest. 70 279-285. 

Mahieux R, Gessain A. HTLV-1 associated adult T-cell leukemia/lymphoma. Rev Clin Exp Hematol 2003 7 336-61. 

Human T-cell lympho trophic vkus type-I (HTLV-I) is an exogenous human retrovirus that causes adult T cell leukemia (ATL) and a progressive neurological disorder, HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP). 

Hinuma Y, Nagata K, Hairaoka M, Nakai M, Matsumoto T, Kinoshita KI, Shirakawa S, Miyoslri 1(1981) Adult T-cell leukemia Airdgen in ai ATL cell line aird detecdon of airdbodies to dre airdgen in humai sera. Proc Natl Acad Sci USA 78 6476-6480. 

Ohaslii T, Hanabuclii S, Kato H, Koya Y, Takemura F, Hirokawa K, Yoshiki T, Tanaka Y Fuji M, Kannagi M (1999) hrduchon of adult T-cell leukemia-like lymphoproliferahve disease and its inliibition by adoptive immunotlieraphy in T-cell-deficient nude rats inoculated witli syngeneic human T-cell leukemia virus type 1-immortalized cells. J Virol 73 6031-6040. 

Teiidler CL, Greenberg SJ, Burton JD, Danielpour D, BUm SJ, Blattner WA, Manns A, Waldmann TA (1991) Cytokine induc-doii ill HTLV-I associated myelopadiy and adult T-cell leukemia Alternate molecular- mechanisms underlying redoviral padiogeri-esis. J Cell Biochem 46 302—311. 

Usuku K, Sonoda S, Osame M, Yashiki S, Takahashi K, Matsumoto M, SawadaT, Tsuji K, TaraM, Igata A (1988) HLAliaplo type-linked high immune responsiveness against HTLV-I in HTLV-I-associated myelopadiy Comparison widi adult T-cell leukemia/lymphoma. Ann Neui-ol 23(Suppl) S 143-150. 

Sasaki H, Nishikata I, Shiraga T et al. Overexpression of a cell adhesion molecule, TSLCl, as a possible molecular marker for acute-type adult T-cell leukemia. Blood 2005 105(3) 1204-1213. 

HTLV-1 and HTLV-2 The human T cell lymphotropic virus type I (HTLV-I) is endemic in some areas of Japan, the Caribbean, and Africa, and has been associated with adult T cell leukemia. In Japan, seroconversion has been observed when anti-HTLV-I-negative patients were transfused with seropositive blood or blood components in one study the conversion rate was 62% (177). However, no case of transfusion-associated adult T cell leukemia has been reported to date (184,185). HTLV-II was originally isolated from a patient with hairy cell leukemia, but... 

Morishima Y, Ohya K, Ueda R, Fukuda T. Detection of adult T cell leukemia virus (ATLV) bearing lymphocytes in concentrated red blood cells derived from ATL associated antibody (ATLA-Ab) positive donors. Vox Sang 1986 50(4) 212-15. 

Chemotherapy-related myelodysplastic syndrome has been reported in association with adult T cell leukemia (80). 

Iwata, S., Hori, T., Sato, N Ueda-Taniguchi, Y., Yamabe, T., Nakamura, H Masutani, H and Yodoi, J. (1994) Thiol-mediated redox regulation of lymphocyte proliferation possible involvement of adult T cell leukemia-derived factor and glutathione in transferrin receptor expression. J. Immunol. 152, 5633-5642. 

Sakashita A, Hattori T, Miller CW, Suzushima H, Asou N, Takatsuki K, Koefiler HP. Mutations of the p53 gene in adult T-cell leukemia. Blood 1992 79 477-80. 

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