Specifications, Centrifugal

Rupture disk, 455 Safety relief valves, 454, 467, 481 Specifications, centrifugal pumps, 209 Spray nozzle particle size, 225 Standards and Codes, 31, 32, 33 Static electricity, 536 Static mixing, 332 Applications, 336 Calculations, 337, 338 Materials of construction, 337 Principles of operation, 335 Type of equipment 334-338... 

After cell disruption, gross fractionation of the properly stabilized, crude cell homogenate may be achieved by physical methods, specifically centrifugation. Figure 7.11, Chapter 7, outlines the stepwise procedure commonly used to separate subcellular organelles such as nuclei, mitochondria, lysosomes, and microsomes. 

Fig. 9 Twelve-stage canned-motor centrifugal Fig. 9.1 Illustration of tandem high-pressure pump in a high-pressure specification centrifugal pump as per Figure 9...

Production and Shipment. Estimated adiponitrile production capacities in the U.S. in 1992 were about 625 thousand metric tons and worldwide capacity was in excess of lO metric tons. The DOT/IMO classification for adiponitrile is class 6.1 hazard, UN No. 2205. It requires a POISON label on all containers and is in packing group III. Approved materials of constmction for shipping, storage, and associated transportation equipment are carbon steel and type 316 stainless steel. Either centrifugal or positive displacement pumps may be used. Carbon dioxide or chemical-foam fire extinguishers should be used. There are no specifications for commercial adiponitrile. The typical composition is 99.5 wt % adiponitrile. Impurities that may be present depend on the method of manufacture, and thus, vary depending on the source. 

Beckman Elutriation Method. The Beckman elutriation method uses a chamber designed so that the centrifugal effect of the radial inward fluid flow is constant (Fig. 3). The separation chambers are made of transparent epoxy resin which faciUtates observation of the movements of the cell boundary in strobe light illumination. This enables detection of the radius at which the cells are separating. When a mixture of cells, eg, mononuclear white cells, enters the chamber, separation can be achieved by fine tuning centrifuge speed and inward fluid flow to the specific cell group. This is a laboratory method suitable for relatively small numbers of cells. Chambers are available in sizes to handle 2-3 x 10 , 1 2 x 10 , and 1 x 10 ° cells. The Beckman chambers can be appHed to collect mononuclear cells from bone marrow aspirates. 

Ammonia, hydrochloric acid, and sodium perchlorate are mixed and the reaction mixture crystallised in a vacuum-cooled crystalliser. Ammonium perchlorate crystals are centrifuged, reslurried, recentrifuged, and then dried and blended for shipment. Mother Hquor is evaporated to precipitate sodium chloride and the depleted mother Hquor is recycled to the reactor. The AP product made by this method is 99% pure and meets the specifications for propeUant-grade ammonium perchlorate. The impurities are ammonium chloride, sodium perchlorate, ammonium chlorate, and water insolubles. 

Time is a critical variable because the magnetite settles if the mixture is held too long in a static condition. Use of hydrocyclones makes possible the separation in a fraction of a minute (21). These devices impart centrifugal force to the system, thereby permitting a separation to be made at a specific gravity less than that required in static, heavy-Hquid separations. 

Motor-driven, multistage reciprocating compressors have reportedly been the most popular choice for aeroderivatives. Motor-driven, oil-fiooded screw compressors are also used in some cases. High horsepower, multistage centrifugal compressors, similar to those used at many pipeline compressor stations, may be required for the newer heavy-duty units if the distribution pipeline pressure is insufficient (see Pipelines). Gas turbines have more stringent fuel-gas specifications in terms of cleanliness than do gas-fired boilers. Thus oil- and water-knockout systems, coalescing filters, and fine-mesh filters are used. 

Selection of pump for a given appHcation is not a trivial task. Often more than one pump type can accomplish the required job. Thus a final choice on a pump type is often a result of personal experience and usage history. As a rule of thumb, the choice of a kinetic, such as centrifugal, or a positive displacement pump is made on the basis of the specific speed. Whereas specific speed is appHcable primarily for centrifugal but not positive displacement pumps, the US value can be used as a guide. Generally, for calculated values of specific speed, eg, nS > 10 [NS > 500), kinetic-type pumps are usually selected. For nS < 10 [NS < 500), positive displacement pumps are typically appHed. 

From the definition of specific speed (eqs. 9 and 10), it follows that reciprocating pumps operate at high pressures and low flow rates. Conversely, centrifugal pumps are appHed at lower pressures and higher flow rates. Many rotary pumps are selected for viscous Hquids having pressures equal to or less than, and capacities lower than, centrifugal pumps. However, these limits are relative and a gray area exists as some pump types cross boundaries into the domain of other types. 

Specification for Hori2ontal End Suction Centrifugal Pumps for Chemical Process," ASME B73.1M, Washington, D.C., 1991. 

R. Hart, Best Practice Centrifugal Pumps. NPSH Definitions and Specifications, Du Pont Internal Specification, Wilmington, Del., May 18,1992. 

The Bottle Centrifuge. Analysis of the performance of a botde centrifuge is based on the model shown in Figure 1. A soHd or Hquid particle is considered in an initial position, X, at a radius, r, from the axis of rotation. If equation 2 is appHed to this specific particle, assuming that = dr/dt then... 

The capacity factor, Zg, defined by equation 7, is derived from a set of assumptions. An additional assumption is specific to the botde centrifuge. Namely, a particle is considered sedimented when it reaches the surface of the cake without contacting the tube wall. 

The Z-concept permits scale-up between sinulat centrifuges solely on the basis of sedimentation performance. Other criteria and limitations, however, should also be investigated. Scale-up analysis for a specified sohds concentration, for instance, requires knowledge of sohds residence time, permissible accumulation of sohds in the bowl, G level, sohds conveyabihty, flowabihty, compressibihty, limitations of torque, and sohds loading. Extrapolation of data from one size centrifuge to another calls for the apphcation of specific scale-up mechanisms for the particular type of centrifuge and performance requirement. 

After centrifugation, the specimens are placed in a holder specifically designed to work with a particular instmment. Some clinical analyzers utilize... 

This specification covers horizontal, end suction, vertically split, single-stage centrifugal pumps with top centerline discharge and hack pullout feature. 

TABLE 18-12 Specifications and Performance Characteristics of Typical Sedimenting Centrifuges... 

Tneory of Centrifugal Filtration Theoretical prechc tions of the behavior of sohd-hquid mixtures in a filtering centrifuge are more (difficult compared to pressure and gravity filtration. The area of flow and driving force are both proportional to the radius, and the specific... 

It is known that the specific resistance for centrifuge cake, especially for compressible cake, is greater than that of the pressure or vacuum filter. Therefore, the specific resistance has to be measured from centrifuge tests for different cake thicknesses so as to scale up accurately for centrifuge performance. It cannot be extrapolated from pressure and vacuum filtration data. For cake thickness that is much smaller compared to the basket radius, Eq. (18-116 7) can be approximated by... 

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