Sodium stearate, magnesium sulfate

Ong et al. [134] found that several hydrophilic anionic, non ionic, or cationic surfactants can alleviate the deleterious effect of magnesium stearate over-mixing on dissolution from capsules when added with the lubricant in a ratio as low as 1 5 (w/w). These successful surfactants were sodium A-lauroyl sarcosinate, sodium stearoyl-2-lactylate, sodium stearate, polox-amer 188, cetylpyridinium chloride, and sodium lauryl sulfate. The lipophilic surfactant glyceryl monostearate did not alleviate the magnesium stearate mixing effect. A reduction in thier particle size was shown to enhance effectiveness, particularly in the case of surfactants with low solubility and slow dissolution rate. 

Lubricants To reduce the friction between the granules and the die wall during compression and ejection of the tableting process Water-insoluble metal stearates, stearic acid, talc Water-soluble boric acid, sodium chloride, benzoate and acetate, sodium or magnesium lauryl sulfate Carbowax 4000 or 6000... 

Hardness in water is caused by the presence of dissolved calcium and magnesium compounds, such as calcium hydrogencarbonate or magnesium sulfate. The hardness of the water can be gauged by its ability to form a thick lather with soap. Water that lathers easily is called soft, whereas water that produces very little lather and a scum, is termed hard. Soap (see page 175) is sodium stearate and scum forms as a result of the precipitation of an insoluble stearate ... 

Polyvinyl butyral Potassium polyacrylate Potassium silicate Potato (Solanum tuberosum) starch, Quaternium-18 bentonite Quaternium- 18/benzalkonium bentonite Quaternium-18 hectorite Rhodapon CAV Shellac, Silica, amorphous hydrated. Silica dimethyl sllylate Silica, hydrated Smectite Sodium chloride Sodium hydrosulfite Sodium magnesium fluorosilicate Sodium polyacrylate Sodium polymelhacrylate Sodium polystyrene sulfonate Sodium slllcoaluminate Sodium stearate Sodium sulfate Stannic oxide Stearalkonlum bentonite Stearalkonium hectorite Stearamide, Stearamide MEA-stearate Stearyl alcohol, Stearyl stearate, Synthetic wax, Tallamide DEA, Tetradecylelcosanol Tetrasodium etidronate Tridecyl alcohol Tridecyl stearate Trihydroxystearin, Trilinoleicacid, Tristearin, Urea-formaldehyde resin. Wheat (Triticum vulgare) starch Xanthan gum. Zinc laurate... 

Norfox KD. See Cocamide DEA Norfox KO. See Potassium oleate Norfox LAS-99. See Sodium dodecyl benzenesulfonate Norfox MCS. See,Methyl cottonseed Norfox MLD. See Methyl lardate Norfox MLS. See Magnesium lauryl sulfate Norfox MOL. See. Methyl oleate Norfox MST. See Methyl stearate Norfox MSY. See Methyl soyate Norfox MTL. See Methyl tallowate Norfox NBC. See Methoxyisopropanol Norfox NP-1. See Nonoxynol-1 Norfox NP-4. See Nonoxynol-4 Norfox NP-6. See Nonoxynol-6 Norfox NP-7. See Nonoxynol-7 Norfox NP-9. See Nonoxynol-9 Norfox NP-12. See Nonoxynol-12 Norfox Oleic Flakes. See Sodium oleate Norfox OP-45. See Octoxynol-5 Norfox OP-100. See Octoxynol-10 Norfox OP-102. See Octoxynol-12 Norfox OP-114. See Octoxynol Norfox PEA-N. See Cocamide DEA Norfox SENS. See Sodium 2-ethylhexyl sulfate... 

Vitamin K Wheat (Triticum vulgare) germ Zinc gluconate Zinc methionine sulfate Zinc oxide Zinc stearate Zinc sulfate Zinc sulfate heptahydrate nutrient, gelatin capsules Retinyi paimitate nutrient, geriatric food Lactose monohydrate nutrient, hair care Sodium pantothenate nutrient, health food Lactose monohydrate Octacosanol nutrient, horticulture Magnesium sulfate heptahydrate nutrient, infant formulas Ferric pyrophosphate Ferrous fumarate Ferrous lactate Ferrous sulfate heptahydrate Inositol... 

Poloxamer 217 stabilizer, food defoamers Sodium polyacrylate stabilizer, food packaging Calcium glycerophosphate Disodium citrate Magnesium glycerophosphate Magnesium phosphate dibasic Potassium citrate Potassium oleate Potassium stearate Sodium 2-ethylhexyl sulfate Sodium phosphate dibasic dihydrate Sodium phosphate dibasic dodecahydrate... 

Silica silylate Smectite Sodium acrylate/vinyl alcohol copolymer Sodium bischlorophenyl sulfamine Sodium carbomer Sodium carboxymethyl betaglucan Sodium carrageenan Sodium cellulose sulfate Sodium chloride Sodium hydrosulfite Sodium lauroyl sarcosinate Sodium magnesium fluorosilicate Sodium myristoyl sarcosinate Sodium m-nitrobenzenesulfonate Sodium oieate Sodium palmate Sodium palmitate Sodium polyacrylate Sodium polymethacrylate Sodium polystyrene sulfonate Sodium sarcosinate Sodium silicoaluminate Sodium stannate Sodium stearate Sodium sulfate... 

Han et al. modified basic magnesium sulfate whiskers using sodium stearate. The method is as follows. First, measure 50 g of basic magnesium sulfate whiskers and prepare a 5% (mass fraction) mixture of whiskers and water. Second, blend the mixture evenly and then keep it at constant temperature at 80°C in a water bath. Third, add sodium stearate to the mixture and stir for 30 minutes. Products are obtained after filtration and low-temperature drying. Finally, strong chemical adsorption between whiskers and sodium stearate develops after modification. 

Modification of the burning rates, pressure exponents, and temp coefficients of burning rate of the fluorocarbon composites has been accomplished with copper, lead, tin, sodium, ammonium and potassium fluoborates sodium, potassium, lithium, lead, copper and calcium fluorides potassium and ammonium dichromate lead and zinc stearate cesium carbonate potassium and ammonium sulfate copper chromite oxides of magnesium, copper and manganese boron zinc dust and carbon black (Ref 75)... 

Fig. 16 Effect of lubricant on dissolution of rate of salicylic acid contained in compressed tablets, x, 3% magnesium stearate , no lubricant 0> 3% sodium lauryl sulfate. (From Ref. 21.).

Fig. 24 The effect of percentage of sodium lauryl sulfate in the formulation on the dissolution of hydrochlorothiazide from capsules containing dicalcium phosphate as filler, 0.75% magnesium stearate, and filled on a dosator machine with 300 N tamping force (USP method 2, 900 mL 0.1 N HC1, 50 rpm). (Adapted from Ref. 71.)... 

Excipients Croscarmellose sodium, edible inks, gelatin, lactose monohydrate, magnesium stearate, povidone, sodium lauryl sulfate, and titanium dioxide... 

Risperdal Risperidone 0.25, 0.5, 1, 2, 3, 4 mg Tablet Schizophrenia A selective monoaminergic antagonist (5HT2, dopamine type 2 (D2), al and a2 adrenergic, and HI histaminergic receptors Colloidal silicon dioxide, hypromellose, lactose, magnesium stearate, MCC, propylene glycol, sodium lauryl sulfate, corn starch Janssen Pharmaceuticals... 

Magnesium stearate, stearic acid, sodium stearyl fumarate Hypromellose, hydroxypropyl cellulose, methylcellolose Ethylenediamine tetraacetic acid, butylated hydroxy toluene Sodium lauryl sulfate, Polysorbate 80 (Tween 80) Cyclodextrins, ethyl alcohol, propylene glycol D-a-Tocopheryl polyethylene glycol 1000 succinate, oleic acid... 

Abbreviations CMM, cellulose microcrystalline PEG, polyethylene glycal CMCNa, sodium carboxymethyl cellulose PVP, Kollidon K30 SDS, sodium docecyl sulfate MgEs, magnesium stearate NF, no flow ability. 

D). Ti02 A. talc (as shoulders of Ti02 bands) (O) lactose ( ) sodium lauryl sulfate ( ) magnesium stearate (T) tadalafil. 

Lubricants based on fatty acids, because of their low water solubility, are unsuitable for tablets which must be dissolved in water before use. Polyethylene glycol 6000 (macrogol 6000) is soluble in water, but its lubricant activity is limited. Magnesium lauryl sulfate has been suggested as a water-soluble substitute for magnesium stearate. In addition to its lubricant action, this substance, like sodium lauryl sulfate, is an effective wetting agent. ... 

Addition of wetting agents such as sodium lauryl sulfate or sodium docusate can assist this water penetration by lowering the surface tension, and they are often used in conjunction with hydrophobic lubricants such as magnesium stearate (see the article on Tablet Disintegrants and Disintegration in this encyclopedia). 

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