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Sodium stearyl fumarate

BP Sodium stearyl fumarate PhEur Natrii stearylis fumaras USPNF Sodium stearyl fumarate [Pg.705]

Fumaric acid, octadecyl ester, sodium salt Pruv sodium monostearyl fumarate. [Pg.705]

2-Butenedioic acid, monooctadecyl ester, sodium salt [4070-80-8] [Pg.705]

Sodium stearyl fumarate is used as a lubricant in capsule and tablet formulations at 0.5-2.0% w/w concentration.It is also used in certain food applications see Section 16. [Pg.705]

Sodium stearyl fumarate is a fine, white powder with agglomerates of flat, circular-shaped particles. [Pg.705]

Polytetrafluoroethylene Sodium stearyl fumarate Stearic acid Talc... [Pg.306]

The most effective lubricants are the hydrophobic stearates, such as magnesium stearate, calcium stearate, and stearic acid. Magnesium stearate is the most widely used lubricant [117,118]. Lubricants proposed as being less hydrophobic such as hydrogenated vegetable oils, polyethylene glycols, and sodium stearyl fumarate are less effective in this application [118]. [Pg.366]

Other studies have been performed to investigate the effect of surface area and tablet lubricant efficacy. In a comparison study between sodium stearyl fumarate and magnesium stearate, it was found that sodium stearyl fumarate was effective as a lubricant to about the same degree as magnesium stearate [15]. It was also reported that the lubricating properties correlated better to the surface area of the lubricant than to the amount of lubricant used. A micronized lubricant was more efficient than a coarse fraction, and it was suggested that the surface area be standardized to obtain reproducible effects. [Pg.262]

One very common beneficial interaction involving an excipient is the interaction between magnesium stearate and the metal of tablet punches and dies, or the equivalent parts on a powder encapsulation machine. Magnesium stearate is an example of a boundary lubricant. As such it has a polar head and a fatty acid tail. It is believed that the polar head of the magnesium stearate is oriented toward the die wall or tablet punch face. In these ways it is able to reduce the ejection force (the force required to eject the tablet from the die after compaction) and prevent sticking to the punch faces. The other boundary lubricants, e.g., calcium stearate and sodium stearyl fumarate, will also function in a similar manner. However, the so-called liquid film lubricants function in a very different manner (19). [Pg.99]

Primary amines may interact with double bonds in a reaction analogous to a Michael addition reaction (e.g., fluvoxamine maleate, where the fluvoxa-mine primary amine group can interact with the double bond in the maleic acid counterion). Examples of excipients that contain double bonds include sodium stearyl fumarate and sorbitan monooleate. [Pg.100]

Mavik Trandolapril 1,2,4 mg Tablet Hypertension The ethyl ester prodrng of a nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor Com starch, croscarmellose sodium, hypromellose, iron oxide, lactose, povidone, sodium stearyl fumarate Abbott Laboratories... [Pg.13]

Tarka Trandolapril/ verapamil HC1 1 mg/240 mg 2mg/180mg 2 mg/240 mg 4 mg/240 mg Extended release tablet Hypertension ACE inhibitor Com starch, dioctyl sodium sulfosuccinate, ethanol, HPC, HPMC, lactose, magnesium stearate, MCC, polyethylene glycol, povidone, purified water, silicon dioxide, sodium alginate, sodium stearyl fumarate, talc, sytnetic iron oxides, titanium dioxide Abbott Laboratories... [Pg.13]

Magnesium stearate, stearic acid, sodium stearyl fumarate Hypromellose, hydroxypropyl cellulose, methylcellolose Ethylenediamine tetraacetic acid, butylated hydroxy toluene Sodium lauryl sulfate, Polysorbate 80 (Tween 80) Cyclodextrins, ethyl alcohol, propylene glycol D-a-Tocopheryl polyethylene glycol 1000 succinate, oleic acid... [Pg.224]

Sodium Stearyl Fumarate occurs as a fine, white powder. It is slightly soluble in methanol, but is practically insoluble in water. [Pg.436]

Sodium stearyl fumarate 0.5-2 Less hydrophobic than metallic stearates, partially... [Pg.890]

Shah, N. H., Stiel, D., Weiss, M., Infeld, M. H., and Malick, A. W. (1986), Evaluation of two new tablet lubricants—Sodium stearyl fumarate and glyceryl behenate. Measurement of physical parameters (compaction, ejection and residual forces) in the tableting process and the effect of the dissolution rate, Drug Dev. Ind. Pharm., 12(8-9), 1329-1346. [Pg.1097]

Microcrystalline cellulose Dibasic calcium phosphate dihydrate Magnesium stearate Sodium stearyl fumarate Stearic acid 175 175 5... [Pg.598]

In addition to SMG and DATEM, some other anionic surfactants that have been tried as dough strengtheners are shown in Eigure 18. Presently SSL is the one most widely used in the United States sodium stearyl fumarate did not find acceptance, and sodium lauryl sulfate is used mainly as a whipping agent with egg whites. [Pg.2225]

Sodium stearyl fumarate Lubricant 0.5-2 Less sensitive to overblending and compressibility... [Pg.990]

A combination of 4% polyethylene glycol (PEG) 6000 and 0.1% sodium stearyl fumarate proved to be a good lubricant for ascorbic acid tablets made by direct compression on a small scale. Sodium chloride, sodium acetate, and D,L-leucine (water-soluble lubricants) also have been suggested for effervescent tablets. ... [Pg.1459]

Lubricants PEG 6000 is most frequently used, alone or with sodium stearyl fumarate, sodium benzoate, sodium chloride, sodium acetate, or D,L-leucine. [Pg.2979]

Sodium stearyl fumarate has been used as an alternative for magnesium stearate. It has about the same lubricating effect, and causes similar tablet strength reduction and prolongation of disintegration time. ... [Pg.3661]

Anhydrous dibasic calcium phosphate is abrasive and a lubricant is required for tableting, for example 1% w/w magnesium stearate or 1 % w/w sodium stearyl fumarate. [Pg.93]

Shah NH, Stiel D, Weiss M, et al. Evaluation of two new tablet lubricants - sodium stearyl fumarate and glyceryl behenate. [Pg.305]

Table I Pharmacopeial specifications for sodium stearyl fumarate. Table I Pharmacopeial specifications for sodium stearyl fumarate.
At ambient temperature, sodium stearyl fumarate is stable for up to 3 years when stored in amber glass bottles with polyethylene screw caps. [Pg.705]

Sodium stearyl fumarate is reported to be incompatible with chlorhexidine acetate. ... [Pg.705]

Stearyl alcohol is reacted with maleic anhydride. The product of this reaction then undergoes an isomerization step followed by salt formation to produce sodium stearyl fumarate. [Pg.705]

Excipient Sodium stearyl fumarate Manufacturer JRS Pharma LP Lot No. 255-01 Magnification 300x... [Pg.706]

See other pages where Sodium stearyl fumarate is mentioned: [Pg.366]    [Pg.29]    [Pg.425]    [Pg.179]    [Pg.233]    [Pg.436]    [Pg.436]    [Pg.436]    [Pg.92]    [Pg.2225]    [Pg.2235]    [Pg.3671]    [Pg.3938]    [Pg.96]    [Pg.705]    [Pg.705]    [Pg.706]   
See also in sourсe #XX -- [ Pg.262 ]

See also in sourсe #XX -- [ Pg.137 , Pg.436 ]

See also in sourсe #XX -- [ Pg.705 ]

See also in sourсe #XX -- [ Pg.226 , Pg.413 ]

See also in sourсe #XX -- [ Pg.84 , Pg.88 , Pg.90 ]



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