D-a-tocopheryl polyethylene glycol

Dintaman JM, Silverman JA. Inhibition of P-glycoprotein by D-a-tocopheryl polyethylene glycol 1000 succinate (TGPS). Pharm Res 1999 16 1550-1556. 

The permeability of two peptides, P-gp substrate and non P-gp substrate, across caco-2 cells in the presence or absence of polysorbate 80 and cremophor EL, commonly used surfactants in pharmaceutical formulations, was investigated. The permeability of the P-gp substrate peptide across caco-2 cells was enhanced in the presence of polysorbate 80 and cremophor EL, whereas the non-P-gp substrate peptide was not affected by these surfactants [94]. Another commonly used lipidic excipient that has been shown to inhibit P-gp mediated efflux is D-a-tocopheryl polyethylene glycol 1000 succinate (TPGS) [95]. The insertion of a known CYP3A4 and P-gp inhibitor to the formulation is another approach to elevate bioavailability. 

Magnesium stearate, stearic acid, sodium stearyl fumarate Hypromellose, hydroxypropyl cellulose, methylcellolose Ethylenediamine tetraacetic acid, butylated hydroxy toluene Sodium lauryl sulfate, Polysorbate 80 (Tween 80) Cyclodextrins, ethyl alcohol, propylene glycol D-a-Tocopheryl polyethylene glycol 1000 succinate, oleic acid... 

Johnson B.M., Charman W.N., Porter C.J.H. (2002) An in vitro examination of the impact of polyehtylene glycol 400, pluronic P85 and vitamin E D-a-tocopheryl polyethylene glycol... 

P-cyclodextrin Transcutol HP Medium-chain diglycerides Medium-chain triglycerides D-a-Tocopheryl polyethylene glycol 1,000 succinate (TPGS)... 

Vitamin E TPGS 10 D-a-tocopheryl polyethylene glycol-1000-succinate N 15-19 0.02 wt.% po, par... 

Zhao, L., Shi, Y., Zou, S., Sun, M., Li, N., and Zhai, G. Eormulation and in vitro evalnation of qnercetin loaded polymeric micelles composed of pluronic P123 and D-a-tocopheryl polyethylene glycol succinates. Journal of Biomedical Nanotechnology 1 (2011) 358-365. 

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