Tableting process

Normally, the lubricants present in the tableting mass also act as antiadherents, but in the worst cases it may be necessary to add more starch or even talc to overcome the defect. So by judicious choice of a combination of excipients, all of these undesirable effects of the tableting process can be minimized. 

Several all-in-one tablet testers are currently available that measure weight, thickness, diameter, and hardness of tablets. In addition these instruments provide digital storage and calculation of statistical parameters and allow for rapid feedback during the tableting process so that the tableting equipment can be adjusted accordingly with minimal downtime. ... 

Keleb El, Vermeire A, Vervaet C, et al. Cold extrusion as a continuous single-step granulation and tableting process. Eur J Pharm Biopharm 2001 52 359-68. 

Successful scale-up of the tableting process also requires control of the raw materials used in compaction. Typically, pharmaceutical excipients vary in their physicochemical properties, which result in batch-to-batch variations. The tableting process, especially direct compression processes where there is limited raw material alteration before compaction, is susceptible to raw material variation, which may be magnified upon scale-up. Compaction science affords the ability to fingerprint raw materials, including the drug substance, to determine if the same compaction properties will be observed from batch to batch. This also allows for a rational approach for determining alternate vendor sources of the same materials. 

As mentioned previously, scale-up effects are important for the tableting process since most tablet development occurs at small-scale to minimize... 

A large difference between the two indices may predict sensitivity to scale-up of the tableting process relating to dwell time of the machine. This tendency, is described as the VI, as shown in Equation (4). However, no correlation of this index to scale-up has been shown to date in the literature. 

Scale-Up of a Sustained Release, Wet Granulation Tableting Process... 

---