Capsules, gelatin

Dronabinol. Marinol ( ii7R-/n7 j )-6i7,7,8,I0i7-tetrahydro-6,6,9-trimethyl-3-pentyl-6JT-diben2o(B,D) pyran-I-ol is the principal psychoactive substance present in Cannabis sativa F., ie, marijuana. It is a controlled substance, formulated in sesame oil and encapsulated in soft gelatin capsules for oral adrninistration. 

The size system of capsules is inversely related to the volume. A No. 1 capsule is larger in volume than a No. 2 a No. 0 is larger than a No. 1. For human consumption. No. 0—2 are most common. Hard-shell gelatin capsules vary in size from those that contain 100 mg of dmg to those for veterinary use, which contain several grams. 

Fig. 2. Rotary die process of soft gelatin capsules where A represents the drug mix B, the mold wedge C, gelatin ribbons D, die roUs E, capsules and F,...

This pigment is recognized by the U.S. Food and Drug Administration (21 Code of Federal Regulations, Part 73) as a color additive exempted from certification (Subpart A, Foods, Section 73.35, Astaxanthin). Formulations containing astaxanthin include soft gelatin capsules containing 100 mg equivalents of total carotenoids, a skin care... 

In addition to the tamper-evident packaging feature described in paragraph (b)(1) of this section, any two-piece, hard gelatin capsule covered by this section must be sealed using an acceptable tamper-evident technology. 

C, powder encased in a cellulose capsule ECMS, enteric-coated microspheres encased in a cellulose or gelatin capsule ECMT, enteric-coated microtablets encased in a cellulose capsule UCT, uncoated tablet P, powder. 

Response rates are lower for non-albicans infections. Although an optimal regimen is unknown, use of intravaginal azole therapy for 7 to 14 days is recommended. Terconazole may prove more effective than other azoles in the treatment of non-albicans infections since C. glabrata and C. tropicalis are more susceptible to terconazole.17 For second-line therapy, boric acid 600 mg in a gelatin capsule administered vaginally twice daily for 2 weeks followed by once daily during menstruation is effective.18 Local irritation often limits the use of boric acid. Topical 4% flucytosine is also effective but use should be limited due to the potential for resistance. 

Boric acid 600 mg in gelatin capsule vaginally daily during menses (5 days)... 

In a study of calves dosed with diisopropyl methylphosphonate at 62.5, 125, 250, 500, or 1,000 mg/kg via gelatin capsules placed with a balling gun, calves at the highest dose level displayed pulmonary emphysema upon autopsy (Palmer et al. 1979). No respiratory effects were observed at sublethal dose levels. 

Plasma levels of diisopropyl methylphosphonate were measured in a single lactating Jersey cow after the sixth day of diisopropyl methylphosphonate oral administration (10 mg/kg/day) by gelatin capsule (Ivie 1980). For the first 5 days the cow was given unlabeled compound and fed hay ad libitum. The diisopropyl methylphosphonate administered on the 6th day was labeled with carbon 14. Based on measurements of label in the plasma, absorption in the cow paralleled that in rats and dogs, with the highest concentration detected in the plasma at 2 hours after administration. 

The study of diisopropyl methylphosphonate distribution in a lactating Jersey cow was the only study that used multiple doses of diisopropyl methylphosphonate (Ivie 1980). In this single cow, radioactivity was detected in the blood 2 hours after dosing with [14C]-radiolabeled compound but not in the tissues. The animal had received diisopropyl methylphosphonate in one gelatin capsule for 5 days before the radiolabeled dose was administered. If tissue uptake in the cow was similar to that in dogs, measurements made 2 hours after dosing may not have provided an opportunity to measure tissue uptake of label. After 24 hours, 0.1% of the administered label was found in the cow s milk (Ivie 1980). 

In a single lactating Jersey cow, 30% of a [14C]-radiolabeled dose of 10 mg/kg/day was excreted in the urine 4 hours after dosing, and 84% was excreted in a 96-hour period (Ivie 1980). The amount of label after 96 hours was 7% in the feces and less than 1% in the cow s milk. Before being given the radiolabeled material, the cow had been administered unlabelled diisopropyl methylphosphonate in a gelatin capsule for 5 consecutive days. 

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