Dosator machine

There are two types of piston-tamp fillers dosator machines and dosing-disc machines. In a recent survey of equipment used in production, it was found that dosator machines are used slightly more frequently than dosing disc machines, with about 18% of the companies responding reporting that they use both types of filling machines [50]. 

Dosator Machines. The dosator machines are exemplified by the Zanasi and MG2 pictured in... 

Fig. 24 The effect of percentage of sodium lauryl sulfate in the formulation on the dissolution of hydrochlorothiazide from capsules containing dicalcium phosphate as filler, 0.75% magnesium stearate, and filled on a dosator machine with 300 N tamping force (USP method 2, 900 mL 0.1 N HC1, 50 rpm). (Adapted from Ref. 71.)... 

In contrast to dosator machines, dosing disc machines form plugs in segments through a series of tamping or compression events. The dosing disc machines made by various manufacturers can vary in the number of... 

A successful filling operation with these machines requires formulation attributes similar to those of dosator machines. Formulations require cohesiveness, and fillers that have been modified to enhance both their... 

The MG-2 series of dosator machines also exhibit similar plug forming parameters across machines with different production capacities. For example, the 16 station (up to 48,000 capsules per hour) and 64 station machines (actually a double 32 station machine up to 200,000 capsules per hour) operate at the same RPM, have the same spacing between dosators, and have similar dosator penetration and withdrawal speeds, plug compression dwell times and plug ejection speeds (McKee, 2005 ). Unlike the powder bed... 

A higher level of compactability is needed for a dosator machine. ° ... 

---