Sensitizers allergic

Poison ivy, poison oak Delayed contact sensitivity (allergic dermatitis)... 

In the OECD test guideline for skin sensitization (OECD TG 406), the following definition is given Skin sensitization (allergic contact dermatitis) is an immunologically mediated cutaneous reaction to a substance. In the human, the responses may be characterized by pruritis, erythema, edema, papules, vesicles, bullae, or a combination of these. In other species, the reactions may differ and only erythema and edema may be seen. ... 

Cross-sensitivity Allergic cross-reactions may occur that could prevent future use of any or all of these antibiotics - Kanamycin, neomycin, paromomycin, streptomycin, and possibly, gentamicin. 

In concentrations greater than 10%, propylene glycol may act as an irritant in some patients those with eczematous dermatitis may be more sensitive. Allergic contact dermatitis occurs with propylene glycol, and a 4% aqueous propylene glycol solution is recommended for the purpose of patch testing. 

Skin sensitization Allergic contact dermatitis. An immunologically modulated cutaneous reaction to a substance or chemical by the animal. Response by humans to skin sensitization are observed in the form of erythema, edema, papules, pruritis, bullae, and vesicles. 

Lopez M, Voigtlander JR, Lehrer SB, Salvaggio JE Bronchoprovocation studies in basidiospore-sensitive allergic subjects with asthma. J Allergy Clin Immrmol 1989 84 242-246. 

Skin sensitization (allergic contact dermatitis, allergic sensitization) can occur following exposure by the... 

Klaewsongkram J, Ruxrangtham K, Wannakrairot P, et al. Eosinophil count in nasal mucosa is more suitable than the number of ICAM-1-positive nasal epithelial cells to evaluate the severity of house dust mite-sensitive allergic rhinitis A clinical correlation study. Int Arch Allergy Immunol 2003 132 68-75. 

Dermatologic reactions following the use of phenothiazine derivatives can be divided into three categories solar sensitivity, allergic dermatitis, and pigment retinopathy. 

HEALTH SYMPTOMS inhalation (irritates eyes, nose and throat) skin contact (severe eye and skin bums, respiratory distress, skin sensitization, allergic reaction). 

Except for contact dermatitis, the route of administration appears to be of little importance in determining the type of hypersensitivity and clinical symptoms produced. Application of allergenic drugs to the skin is usually associated with a high incidence of sensitization (favorable conditions for the formation of conjugates ), whereas the oral route appears to be less likely to foster sensitization. Allergic reactions occur in about 2.5% of patients given penicillin G parenterally, in 5%... 

In general, it can be said that the patient rather than the drug determines the incidence of sensitization. Allergic reactions occur in a comparatively small number of patients who take drugs, since drugs with an unusually high allergic potential (e.g., phenylethylhydantoin) are either kept from distribution or soon withdrawn. 

Baer RL, Ramsay DN (1971) Polyvalent light sensitivity. Allergic contact sensitivity to sulisobenzone (letter). Arch Dermatol 104 446-448 Baer RL, Cohen HJ, Neidorff AH (1959) Allergic eczematous sensitivity to aminophylline. Arch Dermatol 79 647-648... 

Properties Wh. to It. yish. cryst. sol. in acetone, insol. in water m.w. 362.56 m.p. 48 C Toxicology LD50 (oral, rat) 2395 mg/kg nonirritant to skin or eyes may cause sensitization, allergic skin reaction on repeated/prolonged exposure TSCA listed Precaution Incompat. with acids, alkalis, oxidizing agents dust can form explosive mixts. with air... 

In both cases, doses and exposure times are fixed and observations and measurements are made after 1, 24 and 72 h. Skin sensitization (allergic contact dermatitis) is an iramunologically medicated cutaneous reaction. 

The association of household use of hypochlorite with atopic sensitization, allergic disease, and respiratory health status has been assessed in 3626 participants in the European Community Respiratory Health Survey II. Specific serum IgE to four environmental allergens was available and all the participants did the cleaning in their own homes [65 ]. The use of... 

As indicated in Section 1.1, manufacturers must have enough data available to assure cosmetic product safety under the normal conditions of use. Data can be obtained either specifically on the finished products or be deduced from the properties of their ingredients. Moreover, data can be obtained through different studies (toxicology, sensitivity, allergic reactions, etc.), some of which are commented in Section 9.1. Sometimes, surveillance of cosmetics in use can be requested to detect possible side effects. 

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