Eczematous dermatitis

Trautmann A, Akdis M, Kleemann D, Altznauer F, Simon HU, Graeve T, NoU M, Brocker EB, Blaser K, Akdis CA T cell-mediated Fas-induced ker-atinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis. J Clin Invest 2000 106 25-35. Schmidt-Weber CB, Blaser K Regulation and role of transforming growth factor-beta in immune tolerance induction and inflammation. 

Relatively little information is available on the noncarcinogenic effects of benzidine in humans. Acute dermal exposure has reportedly caused severe, recurrent eczematous dermatitis, and chronic exposure may result in sensitization dermatitis. ... 

Phenylhydrazine is a potent skin sensitizer that causes eczematous dermatitis with swelling and vesiculation in a high proportion of individuals who have had repeated skin contact. Based on results with other hydrazines, it is expected that phenylhydrazine could also be absorbed through the skin. ... 

Topical corticosteroids are most useful in inflammatory dermatoses, such as eczematous dermatitis and psoriasis they may also be helpful in other skin diseases that have a prominent inflammatory component, such as autoimmune blistering diseases (e.g., bullous pemphigoid and pemphigus vulgaris) and lupus erythematosus. 

The tricychc tertiary amine doxepin Zonalon, Prudox), a potent Hj- and Hj-receptor antagonist, is indicated for the short-term relief of pruritus associated with topical eczematous dermatitis. Systemic absorption occurs, and the drug may potentiate or alter the metabolism of a va-... 

In concentrations greater than 10%, propylene glycol may act as an irritant in some patients those with eczematous dermatitis may be more sensitive. Allergic contact dermatitis occurs with propylene glycol, and a 4% aqueous propylene glycol solution is recommended for the purpose of patch testing. 

Angelica polymorpha Max. A. sinensis (Oliv.) Diels Dan Gui (root) Vitamin 12, vitamin E, ferulic acid, succinic acid, nicotinic acid, uracil, adenine, butylidenephalide, ligustilide, folinic acid, biotin, polysaccharide33 Treat irregular menstruation, anemia, thrombophlebitis, neuralgia, arthritis, chronic nephritis, constrictive aortitis, skin disease such as eczematous dermatitis. 

Zinc deficiency is clinically characterized by the development of a moist eczematous dermatitis most apparent in the nasolabial folds and around orifices. Other presenting signs and symptoms may include hypogeusia (blunted sense of taste), alopecia, diarrhea, rash (which may vary from papular, scaly lesions to weeping, open erosions), apathy, and depression. Clinical zinc deficiency occurs most frequently in the setting of abnormal losses, such as in Crohn s disease, malabsorption states, and fistula losses, or from prolonged inadequate intake, such as with zinc-free parenteral nutrition. 

Samitz MH, Gross S, Katz S. 1962. Inactivation of chromium ion in allergic eczematous dermatitis. J Invest Dermatol 38 5-12. 

Doxepin is a tricyclic antidepressant that has also been used topically in the treatment of atopic dermatitis and other forms of eczematous dermatitis. It causes the adverse effects that one would expect, and systemic effects can result from absorption after topical administration. 

Drake LA, Millikan LEDoxepin Study Group. The antipruritic effect of 5% doxepin cream in patients with eczematous dermatitis. Arch Dermatol 1995 131(12) 1403-8. 

Simple rashes are not uncommon in patients taking sulfasalazine, including maculopapular rash, pruritus, urticaria, angioedema, eczematous dermatitis, photosensitivity, skin discoloration, and oral ulceration. Raynaud s phenomenon and toxic epidermal necrolysis associated with erythroid hypoplasia and agranulocytosis have occurred in one case of toxic epidermal necrolysis there was marked immunosuppression (SEDA-18, 375). 

Signs of an EFA deficiency can appear in humans after a few weeks on an EFA-deficient diet. The most obvious sign of deficiency is eczematous dermatitis, or scaly skin. Hair loss and impaired woimd healing may also result. EFA deficiency in the rat results in dermatitis, a rough coat of fur, scaly paws and tail, fragility of the capillaries, impaired growth, and impaired reproductive ability. These signs have been identified specifically with a d ciency in linoleic acid, not linolenic acid. 

Nava et al. (19) have reported a case of eczematous dermatitis from TDI. Karol ejt al. (23) reported finding tolyl-specific antibodies in serum of two persons who displayed skin reactions when exposed to TDI. Rothe (25) described 12 cases of contact eczema in workers exposed to MDI or partially polymerized MDI and four similar cases in workers exposed to IPDI. 

Drinking chaparral tea may result in exposure to wood creosote by swallowing. If you drink chaparral tea you may expose your children. Creosote is also found in coal tar shampoos used for anti-dandruff therapy, in coal tar ointments used for treatment of eczematous dermatitis and in mineral coal tar for the treatment of psoriasis. You may expose your children to creosote if... 

Human Toxicity Can cause eczematous dermatitis. Systemic effects similar to phenol, q.v. 

Salicylic acid is irritating to skin and mucosa and destroys epithelial cells. The keratolytic action of the free acid is employed for the local treatment of warts, corns, fiingal infections, and certain types of eczematous dermatitis. After treatment with salicylic acid, tissue cells swell, soften, and desquamate. Methyl salicylate foil of wintergreenj is used topically as a counter-irritant for the relief of mild musculoskeletal pain. 

HUMAN HEALTH RISKS Acute Risks eczematous dermatitis convulsions CNS depression rise in blood pressure peripheral vasoconstriction respiratory failure Chronic Risks skin sensitization effects on liver, kidneys, CNS, cardiovascular system and red blood cells. 

Acute oral and percutaneous toxicity of pyrocatechol is greater than that of phenol inhalation toxicity is less than that of phenol. The toxic symptoms include weakness, muscular pain, dark urine, tremor, dyspnea, and convulsions. Large amounts can produce degenerative changes in renal tubules. Large doses can cause death due to respiratory failure. Skin contact can cause eczematous dermatitis. 

PoLAK, M., and A. M. Mom Histopathology of experimental eczema (allergic contact-type eczematous dermatitis) in man. A study by the technics of silver impregnations of Rio Hortega with special reference to the early microscopic lesions. J. invest. Derm. 13, 125—134 (1949). 

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