Schistosoma mansoni infection

Booth M, Mwatha JK, Joseph S, et al. Periportal fibrosis in human Schistosoma mansoni infection is associated with low IL-10, low IFN-gamma, high TNF-alpha, or low RANTES, depending on age and gender. J Immunol 2004 172(2) 1295-1303. 

Nyame, A.K., Pilcher, J.B., Tsang, V.C.W. and Cummings, R.D. (1996) Schistosoma mansoni infection in humans and primates induces cytolytic antibodies to surface Le(x) determinants on myeloid cells. ExperimentalParasitology82,191-200. 

Smits HH, Hammad H, van Nimwegen M, et al The protective effect of Schistosoma mansoni infection on allergic asthma depends on intensity and chronicity of infection. J Allergy Clin Immunol 2007 120 932-940. 

Araujo MI, Lopes AA, Medeiros M, et al Inverse association between skin response to aeroallergen and Schistosoma mansoni infection. Int Arch Allergy Immunol 2000 123 145-148. 

MC, et al Schistosoma mansoni infection is associated with a reduced course of asthma. J Allergy Clin Immunol 2003 111 947-951. 

Oxamniquine (9.123), a semisynthetic tetrahydroquinoline, is the treatment of choice for Schistosoma mansoni infections. Its mechanism of action is unknown but appears to entail binding of the drug to the nematode s DNA, somehow causing its death. Alternatively, it may cause worm paralysis and expulsion. 

Hedstrom, R., Culpepper, J., Harrison, R.A., Agabian, N. and Newport, C.J. (1987) A major immunogen in Schistosoma mansoni infections is homologous to the heat shock protein Hsp70. The Journal of Experimental Medicine 165, 1430-1435. 

Brunet, L.R., Beall, M., Dunne, D.W. and Pearce, E.J. (1999) Nitric oxide and the Th2 response combine to prevent severe hepatic damage during Schistosoma mansoni infection. The Journal of Immunology 163, 4976-4984. 

Dessein, A.J., Hillaire, D., Elwali, N.E., Marquet, S., Mohamed-Ali, Q., Mirghani, A., Henri, S., Abdelhameed, A.A., Saeed, O.K., Magzoub, M.M. and Abel, L. (1 999) Severe hepatic fibrosis in Schistosoma mansoni infection is controlled by a major locus that is closely linked to the interferon-gamma receptor gene. American journal of Human Genetics 65, 709-721. 

Doenhoff, M.J., Pearson, S., Dunne, D.W., Bickle, Q., Lucas, S., Bain, J., Musallam, R. and Hassounah, O. (1981) Immunological control of hepatotoxicity and parasite egg excretion in Schistosoma mansoni infections stage specificity of the reactivity of immune serum in T-cell deprived mice. Transactions of the Royal Society of Tropical Medicine and Hygiene 75, 41-53. 

Hogg, K.G., Kumkate, S., Anderson, S. and Mountford, A.P. (2003) lnterleukin-12 p40 secretion by cutaneous CD11 c+ and F4/80t- cells is a major feature of the innate immune response in mice that develop Th1 -mediated protective immunity to Schistosoma mansoni. Infection and Immunity 71, 3563-3571. 

MacDonald, A.S., Patton, E.A., La Flamme, A.C., Araujo, M.I., Huxtable, C.R., Bauman, B. and Pearce, E.J. (2002a) Impaired Th2 development and increased mortality during Schistosoma mansoni infection in the absence of CD40/CD1 54 interaction. The journal of Immunology 1 68, 4643-4649. 

Mangold, B.L. and Dean, D.A. (1 992) The role of IgG antibodies from irradiated cercaria-immunized rabbits in the passive transfer of immunity to Schistosoma mansoni-infected mice. American journal of Tropical Medicine and Hygiene 47, 821-829. 

Wolowczuk, I., Nutten, S., Roye, O., Delacre, M., Capron, M., Murray, R.M., Trottein, F. and Auriault, C. (1999a) Infection of mice lacking interleukin-7 (IL-7) reveals an unexpected role for IL-7 in the development of the parasite Schistosoma mansoni. Infection and Immunity 67, 41 83-41 90. 

Miller, A.N., Raghavan, N., FitzGerald, P.C., Lewis, F.A. and Knight, M. (2001) Differential gene expression in haemocytes of the snail Biomphalaria glabrata effects of Schistosoma mansoni infection. International Journal of Parasitology 31, 687-696. 

Nowak, T.S., Woodards, A.C., Jung, Y., Adema, C.M. and Loker, E.S. (2004) Identification of transcripts generated during the response of resistant Biomphalaria glabrata to Schistosoma mansoni infection using suppression subtractive hybridization. Journal of Parasitology 90, 1034-1040. 

Ongele, E. (2000) Differential display analysis of developmentally expressed genes modulated by Schistosoma mansoni infection in Biomphalaria glabrata. PhD thesis. Howard University, Washington, DC. 

Richards, C.S. and Merritt, J.W. Jr (1972) Genetic factors in the susceptibility of juvenile Biomphalaria glabrata to Schistosoma mansoni infection. American Journal of Tropical Medicine and Hygiene 21, 425-434. 

Barakat, R., Farghaly, A., El Masry, A.G., El-Sayed, M.K. and Hussein, M.H. (2000) The epidemiology of schistosomiasis in Egypt patterns of Schistosoma mansoni infection and morbidity in Kafer El-Sheikh. American Journal of Tropical Medicine and Hygiene 62, 21-27. 

Danso-Appiah, A. and De Vlas, S.J. (2002) Interpreting low praziquantel cure rates of Schistosoma mansoni infections in Senegal. Trends in Parasitology 18, 125-129. 

De Clercq, D., Vercruysse, J., Picquet, M., Shaw, D.J., Diop, M., Ly, A. and Gryseels, B. (1999) The epidemiology of a recent focus of mixed Schistosoma haematobium and Schistosoma mansoni infections around the Lac de Guiers in the Senegal River Basin, Senegal. Tropical Medicine and International Health 4, 544-550. 

Gryseels, B., Mbaye, A., De Vlas, S.J., Stelma, F.F., Guisse, F., Van Lieshout, L., Faye, D., Diop, M., Ly, A., Tchuem-Tchuente, L.A., Engels, D. and Polman, K. (2001) Are poor responses to praziquantel for the treatment of Schistosoma mansoni infections in Senegal due to resistance An overview of the evidence. Tropical Medicine and International Health 6, 864-873. 

Stelma, F.F., Talla, I., Polman, K., Niang, M., Sturrock, R.F., Deelder, A.M. and Gryseels, B. (1993) Epidemiology of Schistosoma mansoni infection in a recently exposed community in northern Senegal. American Journal of Tropical Medicine and Hygiene 49, 701-706. 

Ben-Yedidia, T., Tarrab-Hazdai, R., Schechtman, D. and Arnon, R. (1999) Intranasal administration of synthetic recombinant peptide-based vaccine protects mice from infection by Schistosoma mansoni. Infection and Immunity 67, 4360-4366. 

Da Dara, A.A., Skelly, P.J., Walker, C.M. and Harn, D.A. (2003) A DNA-prime/protein-boost vaccination regimen enhances Th2 immune responses but not protection following Schistosoma mansoni infection. Parasite Immunology 25, 429 137. 

Dupre, L., Kremer, L., Wolowczuk, I., Riveau, G., Capron, A. and Locht, C. (2001) Immunostimulatory effect of IL-1 8-encoding plasmid in DNA vaccination against murine Schistosoma mansoni infection. Vaccine 1 9, 1373-1380. 

Flanigan, T.P., King, C.H., Lett, R.R., Nanduri, J. and Mahmoud, A.A. (1989) Induction of resistance to Schistosoma mansoni infection in mice by purified parasite paramyosin. The Journal of Clinical Investigation 83, 1 01 0-1 01 4. 

Hillyer, C.V., Garcia Rosa, M.I., Alicea, H. and Hernandez, A. (1988) Successful vaccination against murine Schistosoma mansoni infection with a purified 12 kD Fasciola hepatica cross-reactive antigen. American Journal of Tropical Medicine and Hygiene 38, 1 03-11 0. 

Hota-Mitchell, S., Siddiqui, A.A., Dekaban, C.A., Smith, J., Tognon, C. and Podesta, R.B. (1997) Protection against Schistosoma mansoni infection with a recombinant baculovirus-expressed subunit of calpain. Vaccine 15, 1631-1640. 

Maddison, S.E., Slemenda, S.B., Chandler, F.W. and Kagan, I.G. (1978) Studies on putative adult worm-derived vaccines and adjuvants for protection against Schistosoma mansoni infection in mice. Journal of Parasitology 64, 986-993. 

Dalton, J.P., Clough, K.A., Jones, M.K. and Brindley, P.J. (1 995) Characterization of the cathepsin-like cysteine proteinases of Schistosoma mansoni. Infection and Immunity 54, 1328-1334. 

Taddese K, Zein ZA. Comparison between the efficacy of oxamniquine and praziquantel in the treatment of Schistosoma mansoni infections on a sugar estate in Ethiopia. Ann Trop Med Parasitol 1988 82(2) 175-80. 

Kilpatrick ME, El Masry NA, BassUy S, Farid Z. Oxamniquine versus niridazole for treatment of uncomplicated Schistosoma mansoni infection. Am J Trop Med Hyg 1982 31(6) 1164-7. 

Jaoko WG, Muchemi G, Oguya FO. Praziquantel side effects during treatment of Schistosoma mansoni infected pupils in Kibwezi, Kenya. East Afr Med J 1996 73(8) 499-501. 

Fletcher M, Teklehaimanot A. Schistosoma mansoni infection in a new settlement in Metekel district, north-western Ethiopia morbidity and side effects of treatment with praziquantel in relation to intensity of infection. Trans R Soc Trop Med Hyg 1989 83(6) 793-7. 

KuUberg MC, Berzofsky JA, Jankovic DL, et al. T cell-derived IL-3 induces the production of IL-4 by non-B, non-T cells to amplify the Th2-cytokine response to a non-parasite antigen in Schistosoma mansoni-infected mice. J Immuno 1996 156 1482-9. 

The association between Schistosoma mansoni infection and HCC appears to be indirect. Patients with S. mansoni have higher incidence of HBV or HCV infection (two viruses associated with cancerogenesis process), compared to noninfected controls (Halim et al. 1999). The high exposnre of schistosomiasis patients to HBV and HCV conld be partly explained by transmission of these viruses during blood transfusion consecutive to haematemesis which is a relatively frequent complication ofhepatosplenic schistosomiasis, via contaminated blood, syringes and needles (Darwish et al. 1993). 

Secor, W.E., Freeman, G.L., and Wirtz, R.A. 1999. Short report prevention of Schistosoma mansoni infections in mice by the insect repellents AI3-37220 and N,N-di-ethyl-3-methylbenzamide. Am.. Trop. Med. Hyg., 60, 1061-1062. 

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