Allergic asthma

Intrinsic asthma, also called idiopathic asthma, usually develops in adulthood. In intrinsic asthma allergic factors are not demonstrable. Episodes of intrinsic asthma may be triggered by a variety of stimuli, eg, emotional state, exposure to cold air, or inert dusts. Both intrinsic and extrinsic asthmatics can be prone to exercise-induced attacks. Individuals who experience a combination of extrinsic and intrinsic asthmatic reactions have mixed asthma. Status asthmaticus refers to an especially acute life-threatening asthma attack which is resistant to normal treatments and which may require hospitalization in order to stabilize the patient. 

CCR3 GW-766994 GlaxoSmithKline Phase II Asthma, allergic rhinitis 111-113, 125... 

Sigesbeckia glabrescens Mak., or hi chum (Korean Fig. 21), is used in Korea to treat liver and kidney diseases, asthma, allergic disorders, costiveness, deafness, and blindness. In China, the plant is prescribed for rheumatic pain, numbness, weak bones, and to wash boils. The anti-inflammatory property of Sigesbeckia glabrescens Mak. is... 

The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema ISAAC. Lancet 1998 351 1225-1232. 

Simons FER Allergic rhinobronchitis the asthma/allergic rhinitis link. J Allergy Clin Immunol 1999 104 543-537. 

It is mainly used for bronchial asthma, allergic illnesses, as an antiedemic for mucous membranes in rhinitis, and also as a drug to increase blood pressure during surgical... 

Mechanism of Action An antiasthmatic and antiallergic agent that prevents mast cell release of histamine, leukotrienes, and slow-reacting substances of anaphylaxis by inhibiting degranulation after contact with antigens. Therapeutic Effect Helps prevent symptoms of asthma, allergic rhinitis, mastocytosis, and exercise-induced bron-chospasm. 

It is a highly, selective glucocorticoid used in asthma, allergic disorders, rheumatoid arthritis and dermatoses. 

Antiulcer agent Bronchial asthma allergic Vaccine... 

Corticosteroids—a group of anti-inflammatory drugs similar to the natural corticosteroid hormones produced by the cortex of the adrenal glands. The disorders that often improve upon corticosteroid treatment include asthma, allergic rhinitis, eczema, and rheumatoid arthritis. 

Eosinophils are leukocytes that contain characteristic cationic proteins in their granules that bind the acidic dye eosin. In contrast to neutrophils, eosinophils are minority cells in the blood and are predominantly tissue-dwelling cells found at sites in contact with the environment the mucosal surfaces of the lung, gastrointestinal tract, and genitourinary tract. Selective accumulation of eosinophils, as opposed to neutrophils, is one of the major pathological features of the inflammatory response to infection with parasitic helminths, and in several diseases such as asthma, allergic rhinitis, and atopic dermatitis. A key step in leukocyte recruitment is the local production of chemoattractant molecules that orchestrate the adhesive interactions between leukocytes and the vascular endothelium. 

Cobalt Anaemia Cardiomyopathy/cardiac failure Respiratory sensitization and asthma Allergic dermatitis... 

Simon RA. Oral challenges to detect aspirin and sulfite sensitivity in asthma. Allerg Immunol (Paris) 1994 26(6) 216-18. 

The mucosal inflammatory responses which accompany asthma, allergic inflammation and helminthic infestations are characterized by a marked and specific infiltration of eosinophils into the relevant mucosal surfeces. Of the cytokines secreted by activated T lymphocytes, IL-3, IL-5 and GM-CSF promote maturation, activation and prolonged survival of the eosinophil (Lopez etal., 1986 Rothenberg et al., 1988, 1989). 11 5 is unique in that, unlike IL-3 and GM-CSF, it acts specifically on... 

Exposures to sick buildings may stimulate respiratory responses in healthy individuals with no previous history of asthma, allergic rhinitis, chronic respiratory disease, recent acute respiratory illness, or extensive exposure to pollutants. Chemicals typically found in sick buildings arise from carpeting, paint, wood products, cleaners, and other sources. These chemicals are mixtures of lipophilic and hydrophilic chemicals and, with the exception of isocyanates from polyurethane wood finishes, are usually... 

A particular aspect of the immune system is that it develops rather late in life. For example thymus development lasts at least until puberty. Over the last couple of years, the need to consider the special vulnerability of the developing immune system has been discussed [74-77], Developmental immunotoxicology might predispose children to those diseases that have been on the rise in recent decades (e.g., childhood asthma, allergic diseases, autoimmune conditions, childhood infections). Our knowledge, especially across species, is still minimal. There are certain possible critical windows of vulnerability of the developing immune system, such as ... 

Dold S, Wjst M, von Mutius E, et al Genetic risk for asthma, allergic rhinitis, and atopic dermatitis. Arch Dis Child 1992 67 1018-1022. (Ill)... 

However, Pearce et al. [14(NC)] have written that the problem of information bias is of particular concern in asthma epidemiology issues because of the difficulties in defining and measuring asthma, allergic rhinoconjunctivitis and atopic eczema, and the difficulties in obtaining exposure information in the aetiologically relevant time period. However, provided that the information has been collected in a standardized manner, then misclassification will be non-differential, and any bias it produces will usually be towards the null value. 

Although, asthma, allergic rhinoconjunctivitis and eczema are related, ISAAC showed that most symptomatic children had symptoms of only one disorder in the previous year, rather than two or three. Observations like this indicate that factors required for the clinical expression of each of these disorders may differ in timing or effect [6(III)]. 

The increase in prevalence of allergic diseases, including allergic asthma, over time is too large to be explained by any genetic variation. There are many studies which show that asthma, allergic rhinoconjimctivitis and atopic eczema are increasing over time. The reasons for this need exploration [19(NC)]. 

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