Fasciola hepatica

Bozas, S.E., Panaccio, M., Creaney, J., Dosen, M., Parsons, J.C., Vlasuk, G.V., Walker, I.D. and Spithill, T.W. (1995) Characterisation of a novel Kunitz-type molecule from the trematode Fasciola hepatica. Molecular and Biochemical Parasitology 74, 19-29. 

Dalton, J.P., McGonigle, S., Rolph, T.P. and Andrews, S.J. (1996) Induction of protective immunity in cattle against infection with Fasciola hepatica by vaccination with cathepsin L proteases and haemoglobin. Infection and Immunity 64, 5066-5074. 

Diaz, F. and Komuniecki, R.W. (1996) Characterization of the alpha-ketoglutarate dehydrogenase complex from Fasciola hepatica potential implications for the role of calcium in the regulation of helminth mitochondrial metabolism. Molecular and Biochemical Parasitology 81,243—246. 

Christian, F.A., T. Tesfamichael, and T. Tate. 1985. Long-term effects of dinoseb and paraquat, both individually and combined, on embryonic development and hatching success of Fasciola hepatica miracidia. Arch. Environ. Contam. Toxicol. 14 149-152. 

Mansour, T. E., Sutherland, E. W., Rail, T. W., and Bueding, E. (1960) The effect of serotonin (5-hydroxytryptamine) on the formation of adenosine 3, 5 -phosphate by tissue particles from the liver fluke, Fasciola hepatica. J. Biol. Chem., 235 466-470. 

Bartlet AL. 1976. Actions of carbon tetrachloride, hexachloroethane and the products of their metabolism in sheep on fasciola hepatica. Br J Pharmacol 58 395-400. 

The molluscicidal activity of imidazo[2,l-/][l,3,4]thiadiazoles and imidazo[2,l-/][l,3,4]oxadiazoles, such as compounds 112 and 109 (Figure 25), have been evaluated against the snail Lymnaea acumiata, which is a vector of the giant liver flukes, Fasciola gigantica and Fasciola hepatica <2004IJC(B)901>. 

Fascioliasis (Sheep liver fluke) Fasciola hepatica Praziquantel or Bithionol-... 

Praziquantel is the agent of choice against all trema-todes apart from Fasciola hepatica where bithionol is the drug of first choice. It is also an anticestodal agent and, as also niclosamide, is a first choice drug for intestinal tapeworm infestations by Taenia solum (pork tapeworm), Taenia saginata (beef tapeworm), Taenia latum (fish tapeworm) and Hymenolepis nana (dwarf tapeworm) and it is a second choice drug af-... 

Graham CS, Brodie SB, and Weller PF. Imported Fasciola hepatica infection in the United States and treatment with triclabendazole. Clin Infect Dis 2001 33 1-5. 

Liver fluke. Fasciola hepatica Egg through miracidium... 

Taenlasis 10 mg/kg single dose H. nana 15-25 mg/kg single dose Neurocysticercosis 50 mg/kg in 3 divided doses x 15 days Schistosome and other flukes except Fasciola hepatica 75 mg/kg/day, can be repeated if needed. 

Fasciola hepatica (sheep liver fluke) Bithionol or triclabendazole ... 

Schulman, M.D. Valentino, D. Purification and characterization of phosphoglycerate kinase from Fasciola hepatica. Mol. Biochem. ParasitoL, 2, 309-321 (1981)... 

Early studies revealed that the 3, 5 -cyclic phosphate diesterase is present in all mammalian tissues (38, 33, 36), being most active in cerebral cortex (36, 37). It has also been identified in extracts of liver fluke (Fasciola hepatica), the common earthworm (Lumbricus terrestris), and fly larvae (36) and it has been studied in marine organisms (38), the cellular slime mold Dictyostelium discovdeum (39, AO), and in E. coli (Al). The enzyme has been partially purified from beef heart (30), dog heart, (A8) and bovine brain (37, A3). No highly purified preparations have yet been obtained and most studies have been performed with relatively crude preparations. 

T. eras = Taenia crassiceps E. multi = Echinococcus multilocularis E. gran G1/G4 = Echinococcus granulosus genotypes G1/G4 F. hep = Fasciola hepatica P. west 2N/3N = Paragonimus westermani diploid/triploid S. jap = Schistosoma japonicum S. malay = Schistosoma malayensis S. mek = Schistosoma mekongi S. man = Schistosoma mansoni. 

Davis, R.E., Singh, H., Botka, C., Hardwick, C., Ashraf el Meanawy, M. and Villanueva, J. (1994) RNA transsplicing in Fasciola hepatica. Identification of a spliced leader (si) RNA and si sequences on mRNAs. Journal of Biological Chemistry 269, 20026-20030. 

Kaplan, R.M., Dame, J.B., Reddy, G.R. and Courtney, C.H. (1995) A repetitive DNA probe for the sensitive detection of Fasciola hepatica infected snails. International journal for Parasitology 25, 601-61 0. 

Le, T.H., Blair, D. and McManus, D.P. (2001a) Complete DNA sequence and gene organization of the mitochondrial genome of the liver fluke, Fasciola hepatica (Platyhelminthes Trematoda). Parasitology 123, 609-621. 

Zurita, M., Bieber, D., Ringold, C. and Mansour, T.E. (1 988) cDNA cloning and gene characterization of the mitochondrial large subunit (LSU) rRNA from the liver fluke Fasciola hepatica. Evidence of heterogeneity in the fluke mitochondrial genome. Nucleic Acids Research 16, 7001-7012. 

Fig. 4.9. Diagrammatic representations of the secondary structures of the nSSU (left) and mtSSU (right) rRNAs. Universal helices are shown in solid black. Helices present in eukaryotic expansion segments of neodermatans are not shaded. Expansion segments are numbered as V1 to V9, following De Rijk et al. (1992). The equivalent numbering scheme used by Gerbi (1996) is indicated in parentheses. Note that the V7 region adjacent to helix 43 might have a different, as yet unknown, structure in cestodes. The mtSSU rRNA structure is based on that for Fasciola hepatica (Le ef al., 2001). Diagram modified from one supplied by Dr Jan Wuyts.

Itagaki, T. and Tsutsumi, K.l. (1 998) Triploid form of Fasciola in Japan genetic relationships between Fasciola hepatica and Fasciola gigantica determined by ITS-2 sequence of nuclear rDNA. International Journal for Parasitology 28, 777-781. 

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