Reversion mutation

Sodium chlorite is not Hsted by the USEPA or any regulatory authority as a carcinogen. Studies conducted ia mice and rats did not show an increase in tumors in animals exposed to sodium chlorite in thek drinking water. Sodium chlorite has been found to have mutagenic activity in some in vitro test systems such as the Ames Salmonella reverse mutation assay without the presence of metaboHc activators. The significance of these test results in regard to human health is not clear because of the oxidizing effects of the chlorite ion (149). [Pg.489]

Physicochemical properties requked include melting/boiling point, vapor pressure, solubiUty, and flammabiUty/explosion characteristics. The toxicological studies include acute toxicity tests, oral, inhalation, and dermal skin and eye kritation skin sensiti2ation subacute toxicity, oral, inhalation, and dermal and mutagenicity tests. In vitro reverse mutation assay (Ames test) on Salmonella typhimurium and/or E.scherichia coli and mammalian cytogenic test. In vivo mouse micronucleus test. [Pg.301]

Figure 4.7 An explanation of the bacterial reverse-mutation test (the Ames test).

Salmonella typhimurium/plate Reverse mutation — — Waters et al. 1982 ... [Pg.84]

Endosulfan is toxic to yeast but is also mutagenic without activation (Yadav et al. 1982). In vitro, endosulfan induced reverse mutations and mitotic gene conversion and increased the percentage of aberrant colonies in Saccharomyces cerevisiae but did not induce mitotic cross-overs (Yadav et al. 1982). [Pg.165]

These principles of reverse mutation are utilized in one important method, the Ames test (section 4.4.2), which is used to detect compounds that act as mutagens or carcinogens (most carcinogens are mutagens). [Pg.484]

S. typhimurium TAIOO (reverse mutation) Gene mutation Waskell 1978... [Pg.161]

Escherichia coli (forward and reverse mutation) Gene mutation +/- No data Greim et al. 1975... [Pg.161]

Much toxicological data are available on this red pigment acute oral toxicity in mice, 90-day subchronic toxicological study, acute dermal irritation and corrosion, acute eye irritation and corrosion, anti-tumor effectiveness, micronucleus test in mice, AMES test Salmonella typhimurium reverse mutation assay), estimation of antibiotic activity, and results of estimation of five mycotoxins. A new patent on Arpink Red was filed in 2001 with claims of anti-cancer effects of the anthraquinone derivatives and apphcations in the food and pharmaceutical fields. [Pg.417]

Salmonella typhimurium TA97, TA98, TA100 Reverse Mutation — — EPA 1984... [Pg.109]

Salmonella typhimurium (reverse mutation) Escherichia coli (forward mutation, DNA modification) Saccharomyces cerevisia (reverse mutation) Bacillus subtilis (rec assay) Gene mutation or DNA modification Bruce and Heddle 1979 Dunkel et al. 1984 Fukunaga et al. 1982 Kharab and Singh 1985 Nestmann et al. 1979 Nishioka 1975 Rosenkranz and Poirier 1979 Simmon 1979b... [Pg.303]

Genotoxicity Bacterial reverse mutation test (Ames test) OECD, US Approved... [Pg.79]

UCW = capped water, TW = tethered water (see text), k = force constant for restraining potential (kcal/mol/A2). b Radius (A) of solvation sphere. 1 Numbers of dynamical water molecules within solvation sphere. d Mean and standard error for the forward (i.e. 8-methyl-N5-deazapterin —> 8-methylpterin) and reverse mutation of the electrostatic force field Cutoff for protein-ligand and solvent-ligand interaction all other interactions are subject to a 9 A cutoff. [Pg.358]

The Ames Salmonella typhimurium microsome reverse mutation test (ability to produce point gene mutations of a base pair). [Pg.1011]

Macgregor, J.T., D.H. Gould, A.D. Mitchell, and G.P. Sterling. 1979. Mutagenicity tests of diflubenzuron in the micronucleus test in mice, the L5178Y mouse forward mutation assay, and the Ames Salmonella reverse mutation test. Mutat. Res. 66 45-53. [Pg.1020]

Assays for Gene Mutations Salmonella Typhimurium reverse mutation assay (Ames test, / ... [Pg.192]

Skin sensitization Ames test To determine the potential to induce skin sensitization reactions To evaluate potential mutagenic activity in a bacterial reverse mutation system with and without metabolic activation... [Pg.493]

Prokaryotic organisms Salmonella typhimurium TA82, TA102 Reverse mutation - Not tested De Flora etal. 1984 KCN... [Pg.108]

S. typhimurium TA98, TA100, TA1535, TA1537, TA1538 Reverse mutation — De Flora 1981 KCN... [Pg.108]

S. typhimurium TA98 TA100 Reverse mutation (+) + Kushi etal. 1983 HCN... [Pg.108]

S. tymphimurium TA97, TA98, TA 100, TA 1535 Reverse mutation - - NTP 1993 NaCN... [Pg.108]