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Bioluminescent reverse mutation assay

Aubrecht, J., Osowski, J.J., Persaud, P., Cheung, J.R., Ackerman, J., Lopes, S.H. and Ku, W.W. (2007) Bioluminescent Salmonella reverse mutation assay a screen for detecting mutagenicity with high throughput attributes. Mutagenesis, 22, 335-342. [Pg.267]

Ackerman J, Sharma R, Hitchcock J, et al. Inter-laboratory evaluation of the bioluminescent Salmonella reverse mutation assay using 10 model chemicals. Mutagenesis. 2009 24(5) 433-438. [Pg.31]

Photobacterium phosphoreum, bioluminescence assay, reverse mutation — + NR Elmore Fitzgerald (1990)... [Pg.186]

Figure 2-2 Bioluminescent Salmonella assay workflow. The luminescent histidine-dependent cells are exposed to tested compounds in agar overlay containing only traces of histidine in multiwell-plate format. The reverse-mutation events restore endogenous histidine synthesis resulting in luminescent colonies of histidine-independent cells that can be visualized via CCD camera. The fully automated instrument in conjunction with automated image analysis of plates enables the analysis of 100 plates in one run. Figure 2-2 Bioluminescent Salmonella assay workflow. The luminescent histidine-dependent cells are exposed to tested compounds in agar overlay containing only traces of histidine in multiwell-plate format. The reverse-mutation events restore endogenous histidine synthesis resulting in luminescent colonies of histidine-independent cells that can be visualized via CCD camera. The fully automated instrument in conjunction with automated image analysis of plates enables the analysis of 100 plates in one run.
See other pages where Bioluminescent reverse mutation assay is mentioned: [Pg.21]    [Pg.21]   
See also in sourсe #XX -- [ Pg.21 ]



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