Proteins inhibition

Pommier Y, Cherfils J (2005) Interfacial protein inhibition a nature s paradigm for drug discovery. Trends Pharmacol Sci 28 136 4-5... 

Yamamoto M, Hayashi N, Takehara T, Ueda K, Mita E, Tatsumi T, Sasaki Y, Kasahara A, Hori M (1999) Intracellular single-chain antibody against hepatitis B virus core protein inhibits the replication of hepatitis B virus in cultured cells. Hepatology 30 300-307 Yang 00, Tran AC, Kalams SA, Johnson RP, Roberts MR, Walker BD (1997) Lysis of HIV-1-infected cells and inhibition of viral replication by universal receptor T cells, Proc Natl Acad Sci USA 94 11478-11483... 

Interferon is a low molecular weight protein, produced by vims-infected cells, that itself induces the formation of a second protein inhibiting the transcriphon of viral mRNA. Interferon is produced by the host cell in response to the vims particle, the viral nucleic and non-viral agents, including synthetic polynucleides such as polyinosinic acid polycytidylic acid (poly I C). There are two types of interferon. 

Abe K, Saito H. Amyloid beta protein inhibits cellular MTT reduction not by suppression of mitochondrial succinate dehydrogenase but by acceleration of MTT formazan exocytosis in cultured rat cortical astrocytes. Neurosci Res 1998 31 295-305. 

Browning, PJ, Roberts, DD, Zabrenetzky, V, Bryant, J, Kaplan, M, Washington, RH, Panet, A, Gallo, RC, and Vogel, T, 1994. Apolipoprotein E (ApoE), a novel heparin-binding protein inhibits the development of Kaposi s sarcoma-like lesions in BALB/c nu/nu mice. J Exp Med 180, 1949-1954. 

Fletcher, C. M., McGuire, A. M., Gingras, A. C., Li, H., Matsuo, H., Sonenberg, N., and Wagner, G. (1998). 4E binding proteins inhibit the translation factor eIF4E without folded structure. Biochemistry 37, 9-15. 

One of the more sensitive indicators of cadmium exposure is the inhibition of non-thionein hepatic metal binding proteins inhibition was observed in juvenile bluegills (Lepomis macrochirus)... 

Majeau, G.R. et al., Mechanism of lymphocyte function-associated molecule 3-Ig fusion proteins inhibition of T cell responses. Structure/function analysis in vitro and in human CD2 transgenic mice, J. Immunol., 152, 2753, 1994. 

Schwiebert, E. M., N. Kizer, D. C. Gruenert, and B. A. Stanton. 1992. GTP-binding proteins inhibit cAMP activation of chloride channels in cystic fibrosis airway epithelial cells. Proc Natl Acad Sci USA 89(22) 10623-7. 

Armstrong attributed the increased resistance of dentin matrix to proteolysis to the blockage of susceptible sites by covalently bound carbohydrate. Later it became clear that the Maillard reaction induces the formation of covalent bonds (cross-links) between protein molecules, accounting for such resistance as well. The presence of non-degradable matrix proteins inhibits mineral dissolution (Chapter 2). In addition, both brown pigments and cross-linked proteins inhibit the production of extracellular polysaccharides by cariogenic streptococci (Kobayashi et al., 1990). 

Three of the MBD family members, namely MeCP2, MBDl, and MBD2, have been shown to act as transcriptional repressors in vitro and in cell culture assays in vivo [86-89,75,76]. Initially it was proposed that methyl-CpG binding proteins inhibit transcription directly, by binding to methylated DNA and blocking the access of transcription factors to their sites at gene promoters. It was soon... 

Such differences have been ascribed to the fact that the cyclase is linked to two distinct guanosine triphosphate (GTP) binding proteins in the cell membrane, termed Gi and Gs. The former protein inhibits the cyclase, possibly by reducing the effects of the Gs protein which stimulates the cyclase. The relationship between the posts)maptic receptor and the second messenger system is illustrated in Figure 2.4. 

Mechanism Bind to digestive enzymes of herbivores variable molecules, specific for proteins Inhibit pathogen s exo-enzyme system... 

Disinfectants come from various chemical classes, including oxidants, halogens or halogen-releasing agents, alcohols, aldehydes, organic acids, phenols, cationic surfactants (detergents) and formerly also heavy metals. The basic mechanisms of action involve de-naturation of proteins, inhibition of enzymes, or a dehydration. Effects are dependent on concentration and contact time. 

Sequestering Proteins Inhibit Assembly by Increasing the Fraction of Actin Present in Monomer Forms... 

Several mechanisms have been postulated to account for thallium s toxicity, including ligand formation with sulfhydryl groups of enzymes and transport proteins, inhibition of cellular respiration, interaction with riboflavin and riboflavin-based cofactors, alteration of the activity of K -dependent proteins, and disruption of intracellular calcium homeostasis. ... 

Zehring WA, Wheeler DA, Reddy P et al 1984 P-element transformation withperiod oca.% DNA restores rhythmicity to mutant, arrhythmic Drosophila melanogaster. Cell 39 369-376 Zeng H, Hardin PE, Rosbash M 1994 Constitutive overexpression of the Drosophila period protein inhibits period mRNA cycling. EMBO J 13 3590-3598... 

Uncouples anaerobic oxidative phosphorylation in tapeworm mitochondria, causing decreased ATP synthesis Binds to tubulin and inhibits polymerization Sensitizes microfilaria, entraps them in reticuloendothelial system Increases membrane permeability, unmasks surface proteins Inhibits fumarate reductase, ATP synthesis binds to tubulin Uncouples oxidative phosphorylation... 

Urakov VN, Valouev lA, Lewitin El, Paushkin SV, Kosorukov VS, Kushnirov VV, Smirnov VN, Ter-Avanesyan MD (2001) Ittlp, a novel protein inhibiting translation termination in Saccharomyces cerevisiae. BMC Mol Biol 2 9-18... 

MecHanism of Action A carbapenem that penetrates the bacterial cell wall of microorganisms and binds to penicillin-binding proteins, inhibiting cell wall synthesis. THerapeuticEffect Produces bacterial cell death. 

Mechanism of Action A fixed-combination carbapenem. Imipenem penetrates the bacterial cell membrane and binds to penicillin-binding proteins, inhibiting cell wall synthesis. Cilastatin competitively inhibits the enzyme dehydropeptidase, preventing renal metabolism of imipenem. Therapeutic Effect Produces bacterial cell death. Pharmacokinetics Readily absorbed after IM administration. Protein binding 13%-21%. Widely distributed. Metabolized in the kidneys. Primarilyexcreted in urine. Removed by hemodialysis. Half-life 1 hr (increased in impaired renal function). 

Fig. 1.20. Positive and negative control of gene activity. Negative control the DNA-bound protein inhibits transcription. For bacterial repression, the binding sites for the RNA polymerase and the repressor partially overlap, and the bound repressor tends to inhibit the association of the RNA polymerase to the promoter. Positive control the bound protein stimnla-tes transcription.

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