Cystic fibrosis airway epithelial cells

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FIGURE 13-1. Electrolyte transport in the airway epithelial cell. Ca, calcium cAMP, cyclic-3, 5 -adenosine monophosphate Cl, chloride Na, sodium K potassium. (From Milavetz G, Smith JJ. Cystic fibrosis. In DiPiro JT, Talbert RL, Yee GC, et al, (eds.) Pharmacotherapy A Pathophysiologic Approach. 6th ed. New York McGraw-Hill 2005 592, with permission.)... 

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Given that most adolescents and adults are chronically colonized with P. aeruginosa, attention has logically been focused on determining the role of this bacterium and its products in the production of pro-inflammatory cytokines and chemokines in normal and cystic fibrosis airway epithelia, and in epithelial cell lines established from patients with cystic fibrosis, or all lines which model the mutation of the CFTR. 

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