Analysis structure-function

A. W. Norman, R. Bouillon, and M. Thomasset, eds.. Vitamin D, Structure, Function Analysis and Clinical Application, Proceedings of the Eighth Workshop on Vitamin D, Paris, July 5, 1991, Walter de Gmyter, Berlin, 1991. 

Ballesteros, J. A., Shi, L., and Javitch, J. A., Structural mimicry in G-protein-coupled receptors implications of the high-resolution structure of rhodopsin for structure-function analysis of rhodopsin-like receptors, Mol. Pharmacol., 60(1), 1-19, 2001. 

Bill, R.M. (2001) Yeast - a panacea for the structure—function analysis of membrane proteins Current Genetics, 40 (3), 157-171. 

Butler, C.S. and Mason, J.R. (1997) Structure-function analysis of the bacterial aromatic ring-hydroxylating dioxygenases. Advances in Microbial Physiology, 38, 47-84. 

Structure-Function Analysis of the Cloned Opiate Receptors... 

Blake AD, Bot G, Reisine T. Structure-function analysis of the cloned opiate receptors peptide and small molecule interactions. Chem Biol 1996 3 967-972. 

Majeau, G.R. et al., Mechanism of lymphocyte function-associated molecule 3-Ig fusion proteins inhibition of T cell responses. Structure/function analysis in vitro and in human CD2 transgenic mice, J. Immunol., 152, 2753, 1994. 

Fanelli, F. and De Benedetti, P.G. (2005) Computational modeling approaches to structure-function analysis of G protein-coupled receptors. Chemical Reviews, 105, 3297-3351. 

Banecki, B., Wawrzynow, A., Puzewicz, J., Georgopoulos, C., and Zylicz, M. Structure-function analysis of the zincbinding region of the Clpx molecular chaperone. J. Biol. Chem. 2001, 276, 18843-18848. 

A highly active structure was predicted based on a structure-function analysis of existing molecules. 

Hybrid and Consensus IFNs. After the sequences of all IFN-a subtypes and their activities were deduced, recombinant hybrids were designed to improve the activity of natural subtypes. It is possible to radically change the properties of an IFN by making hybrids. For example, a hybrid made from the first 61 amino-acid residues of IFN-al and the last 104 amino-acid residues of IFN-a2 exhibited high antiviral activity on mouse cells, while another hybrid produced from the first 91 amino-acid residues of IFN-al and the last 72 amino-acid residues of IFN-a4 had no antiviral effect but displayed enhanced antitumor activity in mice, a property neither of the parent molecules exhibit. Structure-function analysis of hybrid molecules has indicated that the NH2 terminus portion of the IFN-a molecule is important for its biological activity [46]. 

N. Prospects for the Application of Structure-Function Analysis of Steroid Dehydrogenases in Hormone Therapy... 

Synthesis and Structure-Function Analysis of Bioactive Peptides Containing a,P-Didehydro-a-amino Acids... 

Wang, L F, Hertzog, P J, Galanis, M, Overall, M L., Waine, G J, and Linnane, A. W. (1994) Structure-function analysis of human IFN-alpha—Mapping of a conformational epitope by homologue scanning J Immunol 152, 705-715. 

A. Schwienhorst. Structure-function analysis of RNAs generated by In Vivo and In Vitro selection. Z. Phys. Chem., 216 1-17, 2002. 

Lobo BA, Vetro JA, Suich DM et al (2003) Structure/function analysis of peptoid/lipitoid DNA complexes. J Pharm Sci 92 1905-1918... 

Ruppel, K. M., and Spudich, J. A. (1996). Structure-function analysis of the motor domain of myosin. Annu. Rev. Cell Dev. Biol. 12, 543-573. 

Abe T, Morita H, Noma H, Kohno T, Noguchi H, Abe I (2007) Structure function analysis of benzalacetone synthase from Rheum palmatum. Bioorg Med Chem Lett 17 3161-3166... 

Detailed structure-function analysis of a-LTX is impossible without generating mutants. The difficulty inherent to this approach is to ensure proper folding of this large protein. Two groups relied on baculovirus expression and successfully purified active recombinant toxins. Ichtchenko et al. (1998) used two 8-histidine tags for purification, whereas Volynski et al. (1999, 2003) utilized a monoclonal antibody. 

Altstein M., Gazit Y., Ben-Aziz O., Gabay T., Marcus R., Vogel Z. and Barg J. (1996) Induction of cuticular melanization in Spodoptera littoralis larvae by PBAN/MRCH Development of a qualitative bioassay and structure function analysis. Arch. Insect Biochem. Physiol. 31, 355-370. 

Domanski TL, Schultz KM, Roussel F, et al. Structure-function analysis of human cytochrome P-4502B6 using a novel substrate, site-directed mutagenesis, and molecular modeling. J Pharmacol Exp Ther 1999 290 1141-1147. 

Di Pierro M, Lu R, Uzzau S, Wang W, Margaretten K, Pazzani C, Maimone F, Fasano A (2001) Zonula occludens toxin structure-function analysis. J Biol Vhem 276 19160-19165 Doyle LA, Yang W, Abruzzo LY, Krogmann T, Gao Y, Rishi AK, Ross DD (1998) A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc Natl Acad Sci USA 95 15665-15670... 

Tryptophan synthase (EC 4.2.1.20) from bacteria is a classic multienzyme complex that channels a metabolic intermediate (for reviews and commentaries see 1-6)). Structure/ function analysis of tryptophan synthase was pioneered by genetic and biochemical investigations beginning in the mid-1940 s. This chapter emphasizes the relationship between the function of tryptophan synthase and the three-dimensional structure of the tryptophan synthase 02)82 complex from Salmonella typhimurium7,8) and focuses on studies carried out since a recent review.6 ... 

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