Post-emergent

A second class of herbicides primarily affects ( -carotene desaturase. These herbicides are apparent feedback inhibitors of PD as well. This class of compounds includes dihydropyrones like LS 80707 [90936-96-2] (56) and 6-methylpyridines (57,58). The third class consists of the ben2oylcyclohexane-diones, eg, 2-(4-chloro-2-nitroben2oyl)-5,5-dimethyl-cyclohexane-I,3-dione. This class of atypical bleaching herbicides induces phytoene accumulation when appHed either pre- or post-emergence. However, it does not inhibit phytoene desaturase activity in vitro (59). Amitrole also has been considered a bleaching herbicide, though its main mode of action is inhibition of amino acid synthesis. 

Cell Division Inhibitors. The most common mode of action of soil-appHed herbicides is growth inhibition, primarily through dkect or indkect interference with cell division (163). Such growth inhibitory activity is the basis for most pre- or post-emergent herbicides intended to control germinating weed seeds. In germinating seeds, cell division occurs in the meristems of the root and the shoot. Meristematic cells go through a cycle... 

Phenylcarbamates. Phenylcarbamate herbicides represent one of two subgroups of carbamate herbicides, the phenylcarbamates and the thiocarbamates (299). Both groups are prone to volatilization losses the thiocarbamates are particularly susceptible and should be sod-incorporated immediately after apphcation (2). The carbamate herbicides are used, in general, for the selective pre-emergence control of grass and broadleaved weeds (299). Exceptions would include barban, desmedipham, and phenmedipham which are appHed post-emergence. 

Triazines. Triazine herbicides are one of several herbicide groups that are heterocycHc nitrogen derivatives. Triazine herbicides include the chloro-, methylthio-, and methoxytriazines. They are used for the selective pre-emergence control and early post-emergence control of seedling grass and broadleaved weeds in cropland (299). In addition, some of the triazines, particularly atrazine, prometon [1610-18-0] and simazine [122-34-9] are used for the nonselective control of vegetation in noncropland (2). Simazine may be used for selective control of aquatic weeds (2). 

Other Heterocyclic Nitrogen Derivative Herbicides. The herbicides in this group are heterocycHc nitrogen derivatives that do not readily fall into one of the previously discussed groups. They have a wide range of uses and properties. Most of these herbicides are used for selective, pre-and/or post-emergence weed control. Amitrole is used for post-emergence, nonselective weed control in non-croplands and also as an aquatic herbicide (2,296). 

Metal Organics and Inorganics. The metal organic herbicides are arsenicals used for the selective, post-emergence control of grass and broadleaved weeds in cropland and noncroplands. These herbicides are particularly usehil for weed control in cotton and turf crops (2,296,294). CacodyUc acid is a contact herbicide used for nonselective weed control in cropland and noncropland (299). Ammonium sulfamate [7773-06-0] (AMS) is an inorganic herbicide used for control of woody plants and herbaceous perennials (2). 

Miscellaneous Trifluoromethyl Compounds. The herbicides in this group are used for a wide variety of weed-control purposes. Acifluorfen, lactofen [77501-63-4] and oxyfluorfen are used for selective, pre-, and post-emergence weed control in croplands. Fluorochloridone is used for selective, pre-emergence weed control in cropland, and fluridone, fomesafen, and mefluidide [53780-34-0] are used for post-emergence control (296). Fluridone is also used as an aquatic herbicide (2). 

Miscellaneous Other Herbicides. The herbicides in this group are not readily included in any of the preceding groups. Acrolein [107-02-8] (2-propenal) is used as a contact, aquatic herbicide. Sethoxydim, clethodim, and tridiphane are used for selective, post-emergence weed control. 

Cinmethylin and cloma2one [81777-89-1] are used for selective pre-emergence control and etholumesate [26225-79-6] for selective pre- and post-emergence weed control (2,296). 

In addition to the use of 2,4-dichlorophenol in the synthesis of 2,4-D herbicides (acid 2,4-D, acid 2,4-DP, acid 2,4-DB), it is also found in the selective post-emergence herbicide, diclofop-methyl [51338-27-3] (61) and as a selective pre-emergence herbicide, oxadia2on [19666-30-9] (62). A postemergence herbicide is appHed between the emergence of a seedling and the maturity of a crop plant. 

Acylanilides (abbreviated as anilides in this article) are generally used as selective pre- and/or post-emergence herbicides in paddy rice fields. The herbicidal activity of the anilides is similar to those exhibited by the auxin-like plant growth regulators. 

Chloroacetanilides are soil-applied herbicides used for pre- and early post-emergence control of annual grasses and broadleaf weeds in crops. Representative chloroacetanilide compounds, alachlor, acetochlor, and metolachlor, are extensively used worldwide. Other chloroacetanilides with limited usages include propachlor, bu-tachlor, metazachlor, pretilachlor, and thenylchlor. Public environmental concerns and government regulatory requirements continue to prompt the need for reliable methods to determine residues of these herbicides. There now exist a variety of analytical methods to determine residues of these compounds in crops, animal products, soil, and water. The chemical structures and major crops in which these compounds are used are summarized in Table 1. 

Sulfonylurea herbicides are generally applied to crops as an early post-emergent herbicide. Crops that are tolerant to these herbicides quickly metabolize them to innocuous compounds. At maturity, residues of the parent compound in food and feed commodities are nondetectable. Metabolites are not considered to be of concern, and their levels are usually nondetectable also. For this reason, the residue definition only includes the parent compound. Tolerances [or maximum residue limits (MRLs)] are based on the LOQ of the method submitted for enforcement purposes and usually range from 0.01 to 0.05 mg kg (ppm) for food items and up to O.lmgkg" for feed items. There is no practical need for residue methods for animal tissues or animal-derived products such as milk, meat, and eggs. Sulfonylurea herbicides are not found in animal feed items, as mentioned above. Furthermore, sulfonylurea herbicides intentionally dosed to rats and goats are mostly excreted in the urine and feces, and the traces that are absorbed are rapidly metabolized to nontoxic compounds. For this reason, no descriptions of methods for animal-derived matrices are given here. 

In general, triazines are pre- and post-emergence selective herbicides particularly effective on annual and perennial broadleaf and grassy weeds in corn, sorghum, cotton, soybeans, sugar cane, and a host of other fruit and cereal crops. Some have anti-fungicidal properties (e.g., anilazine), and some (e.g., simazine) can be used for... 

Stable in water and under light Bispyribac-sodium is a systemic post-emergence herbicide, used to control a broad range of weeds in rice... 

Stable in neutral to basic aqueous solution Unstable in acidic aqueous solution Flucarbazone-sodium is a post-emergent grass herbicide for use in winter wheat and spring wheat, including... 

Use pattern Prodiamine is used in alfalfa, cotton, soybeans, vines, nuts, and turf as a pre-plant and post-emergence grass and broad-leaved herbicide... 

Pyrithiobac-sodium is a pre- and post-emergence herbicide to control broad-leaved weed and grasses The residue definition is for the parent, pyrithiobac-sodium, only. 

Fluthiacet-methyl is a selective contact herbicide for the post-emergence control of broad-leaved weeds in corn and soybeans. 

Atrazine, used as a selective pre- and post-emergence herbicide to control annual weeds in several crops, is the most representative compound of this group. It is also used as a non-selective herbicide in non-crop areas. After absorption, the compound is metabolized to dealkylated and deisopropy-lated derivatives. The unchanged compound and its metabolites are excreted in urine, where they can be detected by chromatography or enzyme-linked immunosorbent assay (Lucas et al., 1993). A mercapturic acid conjugate of atrazine has also been found in urine samples of workers spraying this herbicide (Lucas et al., 1993) (Table 6). 

Diclofop-methyl is an early post-emergence herbicide applied to cereals, oil seeds and a variety of other crops for the control of annual grasses. Both Diclofop-methyl and its hydrolysis product, diclofop, are herbicidal [200] therefore, analysis for Diclofop-methyl in soil includes the determination of both chemicals. 

Cyperquat, a post-emergence herbicide has been determined in surface soil by a method involving catalytic hydrogenation to l-methyl-4-cyclohexypiperdine and analysis by gas chromatography-mass spectrometry. Recovery of cyperquat from fortified soil samples was 77% at the 0.5mg kgy1 level and 85% at the lmg kgy1 level [213]. 

Inorganic arsenicals such as arsenic trioxide, sodium arsenite, lead arsenate, calcium arsenate and Paris Green have been used for many years as soil sterilants. Organic arsenical herbicides, in which the organic group is bonded directly to the arsenic atom, have been used extensively for post-emergence control of weeds in cotton. Several of the more important herbicides are sodium cacodylate (monosodium dimethylarsenic acid) and sodium salts of methane arsonic acid. The latter compounds exist in two principal forms the monosodium salt (MSMA) at pH6.4 and the disodium salt (DSMA) at pH10.2. 

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