Epidemic polyarthritis

The saltmarsh mosquito pc. vigilax) is a major vector species of the Ross River virus (Epidemic Polyarthritis) in coastal Queensland, Australia. During summer months, widespread spraying of larvae populations is carried out by local authorities in coastal mangrove environments in an attempt to lower mosquito population levels and reduce the incidence of disease transmission. Given the... 

Table 1. Summary of attempts at Ross River virus detection in clinical samples from patients suffering epidemic polyarthritis (EPA) and the nature of the associated cellular response to infection ... 

Abbreviations RRV, Ross River virus Ag, antigen Ab, antibody IFA, immunofluorescent antibody RT-PCR, reverse transcriptase-polymerase chain reaction NK, natural killer ERA, epidemic polyarthritis i.c, intra-cerebral. A survey of the literature between 1990-1999 showed no attemptsat recovering virus from human samples with clinical and epidemiological studies generally relying upon the detection of specific antibodies ... 

Doherty RL> Whitehead RH> Gorman BM et al. The isolation of a third group A arbovirus in Australia with preliminary observations on its relationship to epidemic polyarthritis. Aust J Sci... 

Fraser JRE. Epidemic polyarthritis and Ross River virus disease. Clin Rheum Dis 1986 12 369-388. 

Clarris BJ, Doherty RL, Fraser JR et al. Epidemic polyarthritis a cytological, virological and immunochemical study. Aust N Z J Med 1975 5 450-457. 

Tesh RB, McLean RG, Shroyer DA et al. Ross River virus (To viridae Alphavirus) infection (epidemic polyarthritis) in American Samoa. Trans R Soc Trop Med Hyg 1981 75 426-431. 

Aaskov JG, Ross PV, Harper JJ et al. Isolation of Ross River virus from epidemic polyarthritis patients in Australia. Aust J Exp Biol Med Sci 1985 63 587-597. 

Rosen L, Gubler DJ, Bennett PH. Epidemic polyarthritis (Ross River) virus infection in the Cook Islands. Am J Trop Med Hyg 1981 30 1294-1302. 

Cytokine responsive gene 2 Cytotoxic T lymphocyte Dendritic cell Epidemic polyarthritis Formalin-inactivated RSV Fractalkine Gamma interferon Glycosaminoglycans Heparin-binding domains Herpes simplex virus Human cytomegalovirus Human herpesvirus Human immunodeficiency virus Human leukocyte antigen Interferon... 

Aaskov et al (39) 1981 Yes, by i.c inoculation of suckling mice ("early infection") Not examined "small" effusions noted in ankles, knees etc... Explosive RRV polyarthritis epidemic in Fiji, 4/79-6/79 up to 90% RRV antibody positive post epidemic for some communities... 

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