Hemorrhagic disease

Warfarin is contraindicated in patients with known hypersensitivity to the drug, hemorrhagic disease, tuberculosis, leukemia, uncontrolled hypertension, gastrointestinal (GI) ulcers, recent surgery of the eye or... 

K Phylloquinone, menaquinones Coenzyme in formation of y-carboxyglutamate in enzymes of blood clotting and bone matrix Impaired blood clotting, hemorrhagic disease... 

Rabbit hemorrhagic disease vims VP60 epitope Epitope display on plum pox potyvirus in tobacco leaf Rabbits developed specific antibodies that showed neutralizing activity. Immunogenic when delivered to mice parenterally immunogenic in rabbits when delivered parenterally. Rabbits immunized parenterally survived lethal challenge. 78, 84... 

Rabbit hemorrhagic disease virus VP60 epitope Potato leaf VP60 specific antibodies elicited in rabbits. Immunogenic in rabbits when administered parenterally. Rabbits protected when challenged with virulent RDHV. 67... 

Suggested Alternatives for Differential Diagnosis Foot-and-mouth disease, vesicular stomatitis, peste des petits ruminants, photosensitisation, nasal botfly infestation, pneumonia, akabane infection, epizootic hemorrhagic disease of deer, contagious ecthyma, polyarthritis, footrot, foot abscesses, plant poisonings, and coenurosis. 

Rabbit hemorrhagic disease virus Rhinoviruses STD NMR Virus-ligand interaction... 

Hemorrhagic disease with no connective tissue problems Gum hyperplasia, inflammation, loss of teeth Skeletal deformity in children foot wound healing Anemia... 

Parenteral Anticoagulant-induced prothrombin deficiency hypoprothrombinemia secondary to conditions limiting absorption or synthesis of vitamin K (eg, obstructive jaundice, biliary fistula, sprue, ulcerative colitis, celiac disease, intestinal resection, cystic fibrosis of the pancreas, regional enteritis) drug-induced hypoprothrombinemias due to interference with vitamin K metabolism (eg, antibiotics, salicylates) prophylaxis and therapy of hemorrhagic disease of the newborn. 

Hypoprothrombinemia may occur in malabsorption syndromes and also the use of broad-spectrum antibiotics may produce a hypoprothrombinemia that responds readily to small doses of vitamin K. In premature infants and in infants with hemorrhagic disease of the newborn the use of vitamin K may be indicated. However, the main indication for the use of vitamin K is to antagonize the anticoagulant activity of coumarins. Oral absorption of phytonadione and the menaquinones is by the lymph while menadione and its water-soluble derivatives are absorbed directly. The absorption of phytonadione is energy-dependent and saturable. Intravenous administration of phytonadione has produced flushing, dyspnea, chest pains, and cardiovascular collapse. 

Martin-Alonso, J.M., Castanon, S., Alonso, R, Parra, E, and Ordas, R. (2003). Oral immunization nsing tuber extracts from transgenic potato plants expressing rabbit hemorrhagic disease virus capsid protein. Transgenic Res. 12 127-130. 

Femandez-Femandez, M.R., Mourino, M., Rivera, J. et al. (2001). Protection of rabbits against rabbit hemorrhagic disease vims by immunization with the VP60 protein expressed in plants with a potyvims-based vector. Virology 280 283-291. 

Deficiency of vitamin K in the newborn Newborns have sterile intestines and cannot initially synthesize vitamin K. Because human milk provides only about one fifth of the daily requirement for vitamin K, it is recommended that all newborns receive a single intramuscular dose of vitamin K as prophylaxis against hemorrhagic disease. 

Vitamin K A. plays an essential role in preventing thrombosis. B. increases the coagulation time in newborn infants with hemorrhagic disease. C. is present in high concentration in cow or breast milk. D. is synthesized by intestinal bacteria. E. is a water-soluble vitamin. Correct answer = D. Vitamin K is essential for clot formation, decreases coagulation time, and is present in low concentrations in milk. 

Defects of platelet adhesion to subendothelium—these causing (a) the Bernard-Soulier syndrome, a rare, autosomal recessive trait which results in severe or even fatal hemorrhagic disease (b) von Willebrand s disease, which presents mucocutaneous problems of bruising, epistaxis, and gingival bleeding and (c) pseudo-von Willebrand s disease, in which platelets bind an increased amount of plasma vWF. 

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