Osteogenic

MTX is part of curative therapeutic schedules for acute lymphoblastic leukemias (ALL), Burkitt s lymphoma, and choriocarcinoma. It was also used in adjuvant therapy of breast cancer. High dose MTX with leucovorin rescue can induce about 30% remissions in patients with metastatic osteogenic sarcoma. MTX is one of the few antineoplastic drugs that can be safely administered intrathecally for the treatment of meningeal metastases and leukemic infiltrations (routine prophylaxis in ALL). In addition, MTX can be used as an immunosuppressive agent for the treatment of severe rheumatoid arthritis and psoriasis. 

Gain-of-function (familial, autosomal dominant) High-bone-mass trait (increased osteogenic activity)... 

Bone defects surgically produced in sheep and rabbit models, have been treated with freeze dried methylpyrrohdinone chitosan [334-336]. hi view of improving bone tissue reconstitution with chitosan associated with calcium phosphate. Microscopic and histological analyses showed the presence of an osteogenic reaction moving from the rim of the surgical lesion toward the center. In control lesions, dense fibrous tissue, without the characteristic histoarchitecture of bone was observed. 

Hollinger JO. Preliminary report on the osteogenic potential of a biodegradable copolymer of polyactide (PLA) and polyglycolide (PGA). J Biomed Mater Res, 1983, 17, 71-82. 

Chun C, Lim HJ, Hong KY et al (2009) The use of injectable, thermosensitive poly (organophosphazene)-RGD conjugates for the enhancement of mesenchymal stem cell osteogenic differentiation. Biomaterials 30 6295-6308... 

Interferon does not only inhibit vims replicahon, it also has mulhple effects on cell metabolism and slows down the growth and mulhplicahon of treated cells. This is probably responsible for its widely reported anhtumour effect Encouraging results have been reported from clinical trials of interferon against several human tumours such as osteogenic sarcoma, myeloma, lymphoma and breast cancer. 

YAMAGISHI T, OTSUKA E and HAGIWARA H (2001) Reciprocal control of expression of mRNAs for osteoclast differentiation factor and OPG in osteogenic stromal cells by genistein evidence for the involvement of topoisomerase 11 in osteoclastogenesis. Endocrinol 142, 3632-7. 

Rat" Injection mixture of r 1565 osteogenic sarcoma — — — Strel tsova (1959)... 

Strel tsova, V. N. (1959). Some Mechanisms of Formation of Radioisotope-Induced Osteogenic Sarcomas, Report No. AEC-tr-4087 (National Technical Information Service, Springfield, Virginia). 

Neuss and coworkers have reported the possibility of SMPs using PCL dimethacrylate copolymers as cellular scaffold for tissue engineering. Behaviors of different cells from three different species (human mesenchymal stem cells, human mesothelial cells, and rat mesothelial cells) on the matrices were investigated, and the differentiation capacity of mesenchymal stem cells on the matrices was also analyzed [329]. The SMPs proved biocompatibility for all tested cell types, supporting viability and proliferation. The SMPs also supported the osteogenic and adipogenic differentiation of human mesenchymal stem cells 3 weeks after induction. 

Schoeters GER, Vander Plaetse F, Leppens H, et al. 1995. Haemopoietic and osteogenic toxicity testing in vitro using murine bone marrow cultures. Toxicol In Vitro 9 421-428. 

This is an unusual drug in that it contains a metal atom, platinum (Pt) in this case. Cisplatin reacts with DNA to cross-link bases, disrupting normal DNA structure and function. This agent has found broad use in cancer chemotherapy, including efficacy in tumors of the testis, ovary, bladder, head and neck, thyroid, cervix, and endometrium. It is also active against neuroblastoma and osteogenic sarcoma. 

Beresford JN, Bennett JH, Devlin C, Leboy PS and Owen ME (1992). Evidence for an inverse relationship between the differentiation of adipoc3tiic and osteogenic cells in rat marrow stromal cell cnltnres. J Cell Sci 102 (Pt 2) 341-351. 

An interesting difference in the experimental antitumor spectra of vinblastine and vincristine was noted in that vinblastine was inactive against the Ridgeway osteogenic sarcoma in mice whereas vincristine strongly inhibited the growth of this tumor. Vindesine inhibited the Ridgeway os-... 

Doxorubicin 1974 Osteogenic sarcoma, Hodgkin s disease, CML, soft tissue sarcoma Inhibitor of DNA replication, transcription, repair [20]... 

Zhao Y, Ding S (2007) A high-throughput siRNA library screen identifies osteogenic suppressors in human mesenchymal stem cells. Proc Natl Acad Sci USA 104 9673-9678... 

Mastro AM, Vogler EA (2009) A three-dimensional osteogenic tissue model for the study of metastatic tumor cell interactions with bone. Cancer Res 69 4097 100... 

The radiation from radium can cause cancer in the lung, osteogenic sarcoma, blood dyscrasias and injury to skin. Inhalation, ingestion, skin contact or body exposure to radium and aU its salts must be avoided. 

Bruder SP, Jaiswal N, Haynesworth SE. Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation. J Cell Biocheml997 64 27S-294. 

Jaiswal RK, Jaiswal N, Bruder SP, Mbalaviele G, Marshak DR, Pittenger ME. Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase. J Biol Chem 2000 275 9645-9652. 

Biotech, OP-1 implant is a sterile powder composed of recombinant human osteogenic protein-1 (OP-1) along with bovine collagen. It is used to treat fractured bones that fail to heal. The product is mixed with sterile saline immediately before application, which entails surgical insertion of the paste into the fracture. 

Osteogenic protein 1 (rhOsteogenic Howmedica (EU), Treatment of non-union 2001 (EU, and... 

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