Osteogenic disorder, rats

Kawai, T., Nishikimi, M., Ozawa, T., and Yagi, K., 1992, A missense mutation of L-gulono-y-lactone oxidase causes the inability of scurvy-prone osteogenic disorder rats to synthesize L-ascorbic acid, J. Biol. Chem. 267 21973-21976. 

NT196 Ueta, E., Y. Tadokoro, T. Yamamoto, et al. The effect of cigarette smoke exposure and ascorbic acid intake on gene expression of antioxidant enzymes and other related enzymes in the livers and lungs of Shionogi rats with osteogenic disorders. Toxicol Sci 2003 73(2) 339-347. 

Castagne V, Cuenod M, Do KQ. 2004a. An animal model with relevance to schizophrenia Sex-dependent cognitive deficits in osteogenic disorder-Shionogi rats induced by glutathione synthesis and dopamine uptake inhibition during development. Neuroscience 123 821-834. 

An autosomal recessive mutant strain of rat, which lacks gulonolactone oxidase and hence is unable to synthesize ascorbic acid, has been described (Mizushima et al., 1984). The animals have an osteogenic disorder akin to scurvy in human infants, and homozygotes are sterile. The addition of... 

Abbreviations used in this chapter bp, base pairs FAD, flavine adenine dinucleotide GLO, L-gulono-y-lactone oxidase ODS rat, osteogenic disorder Shionogi rat UDPGT, uridine diphosphate glucuronosyl-transferase. 

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