Osteogenic cell

Beresford JN, Bennett JH, Devlin C, Leboy PS and Owen ME (1992). Evidence for an inverse relationship between the differentiation of adipoc3tiic and osteogenic cells in rat marrow stromal cell cnltnres. J Cell Sci 102 (Pt 2) 341-351. 

Ravelsloot, J.H., van Houten, R.J., Ypey, D.L., et al. (1991) High-conductance anion channels in embryonic chick osteogenic cells. Journal of Bone and Mineral Research 6 355-363... 

Msx2 is expressed in both the mesodermal and neural crest-derived mesenchymal cell populations that give rise to the skull vault (Jabs et al., 1993). It is also expressed in the dura, a membrane that lies between the brain and the skull vault. At later stages Msx2 is expressed in osteogenic cells within the suture (Liu et al., 1999 Rice et al., 2000). 

Lowik, C.W., van der Pluijm, G., Bloys, H., Hoekman, K., Bi-jvoet, O.L., Aarden, L.A., and Papapoulos, SE. (1989) Parathyroid Hormone (PTH) and PTH-Like Protein (PLP) Stimulate Interleukin-6 Production by Osteogenic Cells a Possible Role of Interleukin-6 in Osteoclastogenesis, Biochem. Biophys. Res. Commun. 162,1546-1552. 

Trojani, C. Weiss, R Michiels, J.F. Vinatier, C. Guicheux, J. Daculsi, G. Gaudray, R Carle, G.F. Rochet, N. Three-dimensional culture and differentiation of human osteogenic cells in an injectable hydroxypropylmethylcellulose hydrogel. Biomaterials 2005, 26 (27), 5509-5517. 

Figure 1.12 Schematics illustrating interfacial interactions between bone tissne or cell and implanted biomaterials viewed from the host tissne perspective (a) protein adsorption from blood and tissue fluids, (b) protein desorption, (c) substrate surface changes and material release, (d) inflammatory and connective tissue cells approach the implant, (e) possible targeted release of matrix proteins and selected adsorption of proteins, (f) formation of lamina limitans and adhesion of osteogenic cells, (g) bone deposition on both the exposed bone and implant surfaces, and (h) remodeling of newly formed bone.

Tambasco de Oliveira P, Nanci A. Nanotexturing of titanium-based surfaces upregulates expression of bone sialoprotein and osteopontin by cultured osteogenic cells. Biomaterials... 

Rezania, A., and Healy, K. E. (2(X)0), The effect of peptide surface density on mineralization of a matrix deposited by osteogenic cells, J. Biomed. Mater Res. 52(4) 595-600. 

Thibault, R.A., Baggett, L.S., Mikos, A.G., Kasper, F.K., 2010. Osteogenic differentiation of mesenchymal stem cells on pregenerated extracellular matrix scaffolds in the absence of osteogenic cell culture supplements. Tissue Eng. Part A 16, 431-440. 

In comparison with osteoblasts, tests conducted with the use of human fibroblasts demonstrated higher cytotoxicity of the examined PSU and its composites with nanosilver. After a 24-h incubation of tested materials with fibroblasts, the percentage of the live cells was lower than in the case of the tests performed after 48 h of incubation. Such behavior suggests that, despite the toxic effect, the process of cell multiplication continues. In the case of diluted extracts, a significant decrease of cytotoxicity was observed. The cytotoxic effect of the materials on fibroblasts and the related lower vitality of these cells can be a beneficial phenomenon, if the implant material is intended for the regeneration or replacement of the bone tissue, as one should aim at the activation of the osteoblasts (osteogenic cells) and a simultaneous inhibition of the fibroblasts activity. 

There are two t5 es of bone tissue in the human oiganism. Cortical bone thanks to the presence of Haversian channels shows good osteoconductive properties. Thanks to its mechanical properties it can be used in cases when recreation of tridimensional cavities within the facial part of the skeleton is required. As opposed to cortical bone, cancellous bone is extremely rich in osteogenic cells. Living osteoblasts of cancellous bone may survive even for a few hours from the time of harvesting of the tissue early revascularization in closed cavities takes place after 48 hr. The disadvantage of the cancellous bone grafts is their small mechanical endurance. It is also connected with the lack of possibility to use them in case of tridimensional reconstructions [3]. 

Lohmann CH, Bonewald LF, Sisk MA, Sylvia VL, Cochran DL, Dean DD, et al. Maturation state determine the response of osteogenic cells to surface roughness and 1,25-dihydroxyvitamin D3. J Bone Miner Res 2000 15 1169-80. 

Nishimura N, Kawai T. Effect of microstructure of titanium surface on the behavior of osteogenic cell line MC3T3-E1. J Mater Sci-Mater Methods 1998 9 99-102. 

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