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Nucleophile Nucleophilic attack

Trichloro-s-triazine also reacts readily with carbon or phosphorus nucleophiles. Diethylmalonate anion forms a mono-derivative under mild conditions and the tri-substitution product (327) under vigorous conditions with excess nucleophile. Nucleophilic attack by the 7r-electrons of ketene diethylacetal to give 254 and of dimethylaniline to give 253 has been mentioned earlier. Two... [Pg.303]

The oxathiadiazines (106) (73TL2783) and (107) (77ZC222) are ring opened by nucleophilic attack at the sp2 carbons indicated. The oxathiazine dioxide (108) is reduced to the 3,4-dihydro derivative by 0.5 equivalent LAH (72JOC196), although the isomeric chlorooxathiazine dioxide (109). behaves differently towards nucleophiles. Nucleophilic attack at C-6 followed by elimination of SO3 and chloride ion occurs as shown (80AG(E)131). [Pg.1061]

In 1,2-type azole N-oxides, leaving groups at the 3- and 5-positions are activated toward nucleophilic aromatic substitution since nucleophilic attack at these positions renders intermediates 28 and 34 in which the positive N-oxide nitrogen atom adopts the negative charge brought to the adduct by the nucleophile. Nucleophilic attack at the 4-substituted isomer 30 would give rise to intermediates like 31 in which such stabilization is impossible (Scheme 6). [Pg.5]

We have previously discussed the reduced reactivity to electrophiles of oxazole, imidazole, and thiazole, as compared to furan, pyrrole, and thiophene, which results from the presence of the pyridine-like nitrogen atom. This behaviour is paralleled by increased reactivity to nucleophiles. Nucleophilic attack on furan, pyrrole, and thiophene derivatives only occurs when an additional activating group is present, as in the displacement reaction giving thiophene 3.41. [Pg.26]

An unusual reaction occurs when the pyrimido[5,4-c][l,2,5]oxadiazine (152) is allowed to react with a variety of carbon nucleophiles. Nucleophilic attack at a ring nitrogen atom is followed by ring cleavage, and then decarboxylation and recyclization onto the nucleophile residue. The result is a 6,7-disubstituted pteridine (Equation (12)) (153). Appropriate choice of nucleophile may lead to many different types of substituent on the pteridine <86JHC166l, 91H(32)79>. [Pg.800]

Reduction by complex hydrides Phosphorus nucleophiles Nucleophilic Attack at Hydrogen Attached to Ring Carbon or Ring Nitrogen... [Pg.40]

For S g1 The carbocation reacts with a nucleophile. Nucleophilic attack of CH3OH on the carbocation generates a positively charged intermediate that loses a proton to afford the neutral Snjl product. [Pg.306]

Finally, the polar C-O bonds make the carboxy carbon electrophilic, so carboxylic acids react with nucleophiles. Nucleophilic attack occurs at an sp hybridized carbon atom, so it results in the cleavage of the Jt bond, as well. This reaction is also discussed in Chapter 22. [Pg.699]

Figure 1 Chemical mechanism of DNA polymerase and 3 -5 exonuclease, (a) DNA polymerase reaction. The enzyme chelates two metal Ions using three aspartic acid residues (only two are shown). Metal ion A abstracts the 3 hydroxyl proton of the primer terminus to generate a nucleophile that attacks the a-phosphate of an incoming dNTP substrate. The phosphoryl transfer results In production of a pyrophosphate leaving group, which is stabilized by metal Ion B. (b) The 3 -5 exonuclease proofreading activity is located in a site that is distinct from the polymerase site yet it uses two-metal-ion chemistry similar to DNA synthesis. The reaction type is hydrolysis in which metal ion A activates water to form the hydroxy anion nucleophile. Nucleophile attack on the phosphate of the mismatched nucleotide releases it as dNMP (dGMP in the case shown). Figure 1 Chemical mechanism of DNA polymerase and 3 -5 exonuclease, (a) DNA polymerase reaction. The enzyme chelates two metal Ions using three aspartic acid residues (only two are shown). Metal ion A abstracts the 3 hydroxyl proton of the primer terminus to generate a nucleophile that attacks the a-phosphate of an incoming dNTP substrate. The phosphoryl transfer results In production of a pyrophosphate leaving group, which is stabilized by metal Ion B. (b) The 3 -5 exonuclease proofreading activity is located in a site that is distinct from the polymerase site yet it uses two-metal-ion chemistry similar to DNA synthesis. The reaction type is hydrolysis in which metal ion A activates water to form the hydroxy anion nucleophile. Nucleophile attack on the phosphate of the mismatched nucleotide releases it as dNMP (dGMP in the case shown).
If one of the groups on the alpha carbon contains a lone pair and can act as a Lewis base (e.g., -OH, -OR, or -NH2), that group can chelate with a Lewis acid or the counterion of the nucleophile. Nucleophilic attack of the resulting cyclic, coordinated species occurs at the less hindered face. [Pg.251]

In terms of precedent, copper(I) is well known to bind CO and such adducts typically exhibit high values of v o. which suggest susceptibility to attack by nucleophiles. Nucleophilic attack at Cu-CO by this enzyme, however, is proposed to lead to an O-bound thiocarbonate, which entails scission of an initially formed Cu-CO bond. Precedent for this reactivity is provided by the reaction of Pd(ll) complexes of CNMe with W-SH species (Eq. 12.14) [142]. [Pg.426]

Step 1 Make a new bond between a nucleophile (arene ring) and an electrophile. The phenoxide ion reacts like an enolate anion it is a strong nucleophile. Nucleophilic attack of the phenoxide anion on a carbonyl group of carbon dioxide gives a substituted cyclohexadienone intermediate. [Pg.929]

Linear Alkenes.—Addition of Nucleophiles. Nucleophilic attack on co-ordinated olefins generally occurs only with strong nucleophiles or if the complex is activated, e.g. if it is positively charged. However, malonate ester anions readily add to an olefinic carbon atom of [Fe(CO)4olefin] (olefin=ethylene or methylacrylate). Acidic work-up affords alkene addition products in good yield, equation (4), and a... [Pg.398]


See other pages where Nucleophile Nucleophilic attack is mentioned: [Pg.1256]    [Pg.257]    [Pg.359]    [Pg.980]    [Pg.3]    [Pg.586]    [Pg.1045]    [Pg.347]    [Pg.980]    [Pg.347]    [Pg.358]    [Pg.347]    [Pg.1041]    [Pg.946]    [Pg.183]    [Pg.207]    [Pg.271]    [Pg.483]   
See also in sourсe #XX -- [ Pg.141 , Pg.167 , Pg.168 , Pg.344 ]




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1-Haloalkynes, nucleophilic attacks

13- Lactam nucleophilic attack

13- Lactam nucleophilic attack, intramolecular

2- Azetidinones nucleophilic attack

2-Alkyl-3-isothiazolinones, nucleophilic attack

2-Oxetanones nucleophilic attack

A Nucleophilic Attack on Carbon

Acetate nucleophilic attack

Acetylenes nucleophilic attack

Acid-catalyzed nucleophilic attack at carbon

Acridine nucleophilic attack

Activation of a Substrate toward Nucleophilic Attack

Acyl nucleophile attack

Aldehydes nucleophilic attack

Alkene complexes nucleophilic attack

Alkene ligands nucleophilic attack

Alkenes coordinated, nucleophilic attack

Alkenes nucleophilic attack

Alkyl groups, nucleophilic attack

Alkyl ligands nucleophilic attack

Alkylidenes nucleophilic attack

Alkylidynes nucleophilic attack

Alkyne complexes nucleophilic attack

Alkynes nucleophilic attack

Alkynes, nucleophilic attack upon

Allene complexes nucleophilic attack

Allyl Complexes by Nucleophilic Attack

Allyl complexes nucleophilic attacks

Allyl ligand, nucleophilic attack

Allylic compounds, nucleophilic attack

Allylic systems, nucleophilic attack

Amines nucleophilic attack

Anthracene nucleophilic attack

Arenes nucleophilic attack

Aryl groups, nucleophilic attack

Attack by Nucleophiles

Attack of nucleophile

Azine substitution —cont by nucleophilic attack

Aziridines nucleophilic attack

Azlactones nucleophilic attack

Benzofuroxans nucleophilic attack

Bonding nucleophilic attack

Bonds nucleophilic attack

By nucleophilic attack onto carbonyl groups

Cage Helicity and Further Consequences Nucleophilic Attack on Quinuclidin-3-ones

Carbenes nucleophilic attack

Carbon monoxide nucleophilic attack

Carbon nitrogen nucleophile attack

Carbon nucleophilic attack

Carbonyl activation, nucleophilic attack

Carbonyl clusters, nucleophilic attack

Carbonyl compounds nucleophilic attack

Carbonyl group nucleophilic attack

Carbonylation nucleophilic attack

Carboxamides nucleophilic attack

Carboxylic acid derivatives, nucleophilic attack

Carbyne complexes nucleophilic attack

Cascade intramolecular nucleophilic attack

Chalcogen nucleophilic attack

Chromium carbonyl nucleophilic attack

Cieplak nucleophilic attack

Cobalt complexes nucleophilic attack

Coordinated ligand, nucleophilic attack

Cyclative cleavage nucleophile attack

Cyclohexanones nucleophilic attack

Cysteine in Nucleophilic Attack

Diastereoselective Nucleophilic and Electrophilic Attack on Double Bonds Free of Steric Effects

Diene complexes nucleophilic attack

Dienes nucleophilic attack

Dinitrogen nucleophilic attack

Electronegative elements nucleophilic attack

Electrophiles nucleophilic attack

Electrophilicity nucleophilic attack

Electropositive element nucleophilic attack

Elimination happens when the nucleophile attacks hydrogen instead of carbon

Epoxides nucleophilic attack

Ethyl acrylate nucleophilic attack

External attack of nucleophiles on alkene coordinated to electrophilic metal complexes

From 1,2 dienes nucleophilic attack

Frontside nucleophilic attack

Glutamate-43, nucleophilic attack

Glycals nucleophilic attack

Haloarenes nucleophilic attack

Halodeoxy sugars nucleophilic attack

Heterocyclic intramolecular nucleophilic attack

Hiickel calculations nucleophilic attack

Hydroxide, nucleophilic attack

Imine complexes nucleophilic attack

Imines nucleophilic attack

Iminium ions, nucleophilic attack

Intermolecular reactions nitrogen nucleophile attacks

Intermolecular reactions oxygen nucleophile attacks

Intramolecular nucleophilic attack Subject

Irene complexes nucleophilic attack

Iron nitrosyls nucleophilic attack

Isonitriles nucleophilic attack

Ketones nucleophilic attack

Lactones nucleophilic attack

Ligand substitution reactions nucleophilic attack

Ligands nucleophilic attack

Maleic anhydride nucleophilic attack

Masochistic nucleophilic attack

Metal carbonyls nucleophilic attack

Metal-activated nucleophilic attack

Metathesis nucleophilic attack

Methyl acrylate nucleophilic attack

Methyl group nucleophilic attack

Methyl nucleophilic attack

Methyl vinyl ketone nucleophilic attack

Methylplatinum complexes nucleophilic attack

Migration-nucleophilic attack-cyclization

NUCLEOPHILIC ATTACK ON PROTONS ATTACHED TO RING ATOMS

NUCLEOPHILIC ATTACK ON RING CARBON ATOMS

NUCLEOPHILIC ATTACK ON RING HETEROATOMS

Nitric oxide nucleophilic attack

Nitriles nucleophilic attacks

Nitrogen nucleophiles catalysis, intramolecular attacks

Nucleophile attack

Nucleophile attack

Nucleophiles attack

Nucleophiles attack

Nucleophiles transition-metal complexes attacked

Nucleophilic Attack Other Than at the Metal Atom

Nucleophilic Attack at CO Ligands

Nucleophilic Attack at Halogen

Nucleophilic Attack at Hydrogen

Nucleophilic Attack at Other Atoms

Nucleophilic Attack at Phosphorus

Nucleophilic Attack at Ring Carbon

Nucleophilic Attack at Ring Nitrogen

Nucleophilic Attack at Ring Sulfur

Nucleophilic Attack at the Ligands

Nucleophilic Attack by Oxygen

Nucleophilic Attack by Phosphorus

Nucleophilic Attack on Carbon

Nucleophilic Attack on Co-ordinated Nitriles

Nucleophilic Attack on Coordinated Double Bonds

Nucleophilic Attack on Halogen

Nucleophilic Attack on Hydrogen Attached to Carbon

Nucleophilic Attack on Hydrogen Proton Abstraction)

Nucleophilic Attack on N Aromatics Pyrrole and Pyridine

Nucleophilic Attack on Other Atoms

Nucleophilic Attack on Ring Carbon

Nucleophilic Attack on Ring Hydrogen (Proton Abstraction)

Nucleophilic Attack on Sulfur

Nucleophilic Attack on Transition Metal Complexes of Carbon Monoxide and Isonitriles

Nucleophilic Attack on Z-Substituted Benzenes

Nucleophilic Attack on a Carbonyl Group

Nucleophilic Attack on a Coordinated Ligand

Nucleophilic Attack on a Ligand

Nucleophilic Attack on a Temporarily Formed Imino Group

Nucleophilic Attack on the Ligands

Nucleophilic amidines, attack

Nucleophilic and Electrophilic Attack on Cycloalkenes

Nucleophilic and electrophilic attack

Nucleophilic attack

Nucleophilic attack

Nucleophilic attack 4- coordinate complexes

Nucleophilic attack 5- coordinate intermediate structure

Nucleophilic attack 5-coordination site involvement

Nucleophilic attack Ritter reaction

Nucleophilic attack Subject

Nucleophilic attack activation parameters

Nucleophilic attack alkyl halides

Nucleophilic attack at carbon

Nucleophilic attack at coordinated ligand

Nucleophilic attack at hydrogen (Deprotonation)

Nucleophilic attack at silicon

Nucleophilic attack at sulfur

Nucleophilic attack at the carbonyl group

Nucleophilic attack bimolecular transfer

Nucleophilic attack by hydride on

Nucleophilic attack by hydride on aldehydes and ketones

Nucleophilic attack by metal

Nucleophilic attack by unsaturated carbon

Nucleophilic attack carbonium ions

Nucleophilic attack catalysis

Nucleophilic attack chiral enolate

Nucleophilic attack complex rate laws

Nucleophilic attack concerted mechanism

Nucleophilic attack conjugate base mechanism

Nucleophilic attack equilibrium conditions

Nucleophilic attack fluxionality

Nucleophilic attack fundamental principles

Nucleophilic attack gold complexes

Nucleophilic attack halogen molecules

Nucleophilic attack hydrocarbon complexes

Nucleophilic attack initiation

Nucleophilic attack initiation characteristics

Nucleophilic attack initiation kinetics

Nucleophilic attack initiation mechanism

Nucleophilic attack intimate mechanisms

Nucleophilic attack intramolecular

Nucleophilic attack ligand-dependent pathway

Nucleophilic attack metal-olefin complexes

Nucleophilic attack nickel complexes

Nucleophilic attack of aldehydes and ketones

Nucleophilic attack of carbonyls

Nucleophilic attack of methoxide

Nucleophilic attack olefins

Nucleophilic attack on activated

Nucleophilic attack on allylic compounds

Nucleophilic attack on carbonyl groups

Nucleophilic attack on carbonyls

Nucleophilic attack on coordinated

Nucleophilic attack on coordinated ligands

Nucleophilic attack on coordinated olefins

Nucleophilic attack on epoxide

Nucleophilic attack on organotransition

Nucleophilic attack on organotransition metal complexes

Nucleophilic attack orbital interactions controlling

Nucleophilic attack orbital overlap

Nucleophilic attack oxidation

Nucleophilic attack oxidative addition reactions

Nucleophilic attack palladium complexes

Nucleophilic attack physical properties

Nucleophilic attack platinum complexes

Nucleophilic attack polar solvent effect

Nucleophilic attack reactions

Nucleophilic attack reduction reactions

Nucleophilic attack regiospecificity

Nucleophilic attack relative reactivities

Nucleophilic attack reverse hydrolysis

Nucleophilic attack rhodium compounds

Nucleophilic attack solubility

Nucleophilic attack solvation

Nucleophilic attack stability

Nucleophilic attack stereoselectivity

Nucleophilic attack steric effects

Nucleophilic attack substitution

Nucleophilic attack tetrahedral carbon center

Nucleophilic attack transition metal complexes

Nucleophilic attack trigonal bipyramids

Nucleophilic attack trigonal-bipyramidal transition state

Nucleophilic attack types

Nucleophilic attack via single-electron transfer

Nucleophilic attack, 1,2-dithiolium ring

Nucleophilic attack, electron transfer reactions

Nucleophilic attack, ester hydrolysis

Nucleophilic attack, glutathione conjugation

Nucleophilic attack, of water molecules

Nucleophilic attack, propargylic centers

Nucleophilic attacks isocyanide complexes

Nucleophilic attacks nitrile complexes

Nucleophilic attacks phosphate esters

Nucleophilic back-side* attack

Nucleophilic substitution ligand attacks

Nucleophilic ‘front-side’ attack

Nucleophilic-electrophilic attack at coordinated carbonyls

Olefin complexes nucleophilic attack

Olefin complexes nucleophilic attack upon

Orientation of nucleophilic attacks

Orthoesters, nucleophilic attack

Oxazoles nucleophilic attack

Oxonium ions, nucleophilic attack

Oxygen nucleophiles intramolecular attacks

Palladium complexes olefin, nucleophilic attack

Palladium nucleophilic attack

Palladium promotion of nucleophilic attack

Palladium-allyl complexes nucleophilic attacks

Perfluoroalkenes nucleophilic attack

Polyenes open, nucleophilic attack

Pyridazine 1-oxides, nucleophilic attack

Pyridine nucleophilic attack

Pyridinium cations nucleophilic attack

Pyrrole nucleophilic attack

Quinoline nucleophilic attack

Reactivity with the Attacking Nucleophile

Relative rates of nucleophilic attack

Replacement by Nucleophilic Attack

Reversibility of nucleophilic attack

Ring closure by nucleophilic attack

Ruthenium nitrosyls nucleophilic attack

Stereochemistry of nucleophilic attack

Succinimide, nucleophilic attack

Terminal acetylenes nucleophilic attacks

Tetrahedral nucleophilic attack

The Attacking Nucleophile

The Direction of Nucleophilic Attack and Orbital Steering

The angle of nucleophilic attack on aldehydes and ketones

The site of nucleophilic attack

Thioesters nucleophilic attack

Thiolactones nucleophilic attack

Titanium isopropoxide nucleophilic attack

Transition metal clusters and nucleophilic attack

Water, nucleophilic attack

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