Nucleophilic Attack on a Temporarily Formed Imino Group

Nucleophilic Attack on a Temporarily Formed Imino Group 

Pictet-Spengler cyclocondensation is a versatile method for the construction of tetrahydro-P-carboline ring systems. It comprises the acid-catalyzed reaction 

5 Hydroformylation Followed by Another C-C-Bond Formation Step S13 

As seen in Section 5.2, under hydroformylation conditions or with pure H2, the aldehyde can immediately react with hydrogen to produce the corresponding primary alcohols. However, also a final borylation step with formation of secondary 

Electrophilic Attack by Carbon Nucleophiles in the (t-Position to the Newly Formed Formyl or Imino Group 

---