Nitrites, incompatibilities with

Care must be exercised in using sodium nitrite near other chemicals. It is incompatible with ammonium salts, thiocyanates, thiosulfates, and strong reducing agents. In acid solutions, sodium nitrite evolves toxic NO in the presence of secondary amines it can form nitrosamines which are suspected carcinogens. 

Amifostine Amifostine is incompatible with many drugs such as acyclovir sodium, amphotericin, cefoperazone sodium, hydroxyzine hydrochloride, miconazole, minocycline hydrochloride, and prochlorpherazine edisylate.239 Care should be exercised when handling amyl nitrate, since it is highly flammable. Volatile nitrites, such as poppers, are abused and fatal adverse effects are reported.240,241... 

SAFETY PROFILE A poison. Flammable by spontaneous chemical reaction, air, moisture, or acid fumes may cause it to ignite. For explosion and disaster hazards, see SULFIDES. To fight fire, use CO2, dry chemical. Reacts violently with phosphorus(V) oxide. Mixtures with lead dioxide, potassium chlorate, or potassium nitrite explode when heated. Incompatible with CI2O, Ca(N03)2, Sr(N03)2, Ca(C103)2, Sr(C103)2, (C103)2. See also BARIUM COMPOUNDS (soluble) and SULFIDES. 

DOT CLASSIFICATION 6.1 Label Poison SAFETY PROFILE Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion nausea or vomiting, hypermotility, diarrhea, kidney changes, somnolence. Hydrolyzes to toxic fumes. A friction- and impact-sensitive explosive. It may initiate detonation of liquid hydrogen cyanide. Incompatible with fluorine, magnesium, sodium nitrite. When heated to decomposition it emits very toxic fumes of Hg, NO, and CNT See also CYANIDE and MERCURY COMPOUNDS. 

SAFETY PROFILE Moderately toxic by subcutaneous route. Incompatible with metal nitrates, sodium nitrite. When heated to decomposition it emits very toxic fumes of Na20 and SO. See also SODIUM THIOSULFATE and SODIUM THIOSULFATE, PENTAHYDRATE. 

Some antioxidants possess antimicrobial properties, such as propyl gallate and butylated hydroxy anisole, which are somewhat effective against bacteria. Butylated hydroxy toluene has demonstrated some antiviral activity. Compatibility of antioxidants with the drug, packaging system and the body should be studied carefully. For example, tocopherols may be absorbed onto plastics ascorbic acid is incompatible with alkalis, heavy metals, and oxidizing materials such as phenylephrine, and sodium nitrite and propyl gallate forms complexes with metal ions such as sodium, potassium and iron. 

Incompatible with alkalis, heavy metal ions, especially copper and iron, oxidizing materials, methenamine, phenylephrine hydrochloride, pyrilamine maleate, salicylamide, sodium nitrite, sodium salicylate, theobromine salicylate, and picot-amide. Additionally, ascorbic acid has been found to interfere with certain colorimetric assays by reducing the intensity of the color produced. ... 

Potassium metabisulfite is incompatible with strong acids, water, and most common metals. It reacts with nitrites and sodium nitrate at room temperature, which occasionally results in the formation of flame. The reaction may be explosive if water is present. Potassium metabisulfite liberates SO2 with acids. 

AMERCIDE (133-06-2) see captan. AMETOX (10102-17-7 NajSjOjSHjO Violent reaction with strong oxidizers metal nitrates, nitrites. Forms explosive product with potassium nitrate, sodium nitrate. Reacts with acids, forming sulfur dioxide. Incompatible with halogens. 

Incompatible with sulfuric acid, isocyanates, chlorates, nitrates, nitrites, with loss of toxic ammonia, hydrogen sulfide, and sulfur trioxide gases. In temperatures above 302°F/150°C, releases toxic flunes of ammonia, hydrogen sulfide, and oxides of nitrogen and sulfiir. 

AMMONIUM SULPHATE (7783-20-2) H8N2O4S Noncombustible solid. Aqueous solution is a strong acid. Violent reaction with fused potassium chlorate potassium nitrite. Reacts with caustics, forming ammonia. Hot material reacts with nitrates, nitrites, chlorates. Incompatible with strong oxidizers sulfuric acid aliphatic amines alkanolamines, amides, organic anhydrides isocyanates, vinyl acetate aUcylene oxides epichlorohydrin. Mixture with sodium hypochlorite forms nitrogen trichloride, an unstable explosive material. Attacks metals in the presence of moisture. 

BARIUM SULFIDE (21109-95-5) BaS Flammable solid. Oxidizes in dry air. Contact with acid, acid fumes, moisture, steam, or moist air causes decomposition with the formation of toxic and flammable hydrogen sulfide gas. Evolved gas can form explosive mixtures with air and may cause spontaneous ignition or explosion. Violent reaction with strong oxidizers, calcium chlorate calcium nitrate chlorine dioxide phosphorus(V) oxide strontium chlorate strontium nitrate. Incompatible with lead dioxide, potassium chlorate, potassium nitrite may explode at elevated temperatures. On small fires, use smothering quantities of dry chemical powder, dry clay, dry groimd limestone (CaCOj), dry soda ash,dry sand or approved Class D extinguishers, do not use water, foam, or hydrous agents. 

Combustible solid.Dust may form explosive mixture with air (flash point 334°F/168°C Fire Rating 1). Violent reaction with nitric acid forms explosive nitro materials in the presence of sulfuric acid. Dust and powder forms explosive mixture with air. Incompatible with strong acids, alkalis, aliphatic amines, alkanolamines, alkylene oxides, ammonia, epichlorohydrin, isocyanates, nitrates, nitromethane, sodium nitrite, strong oxidizers. On small fires, use dry chemical powder (such as Purple-K-Powder), Halon , alcohol-resistant foam, water spray, or CO2 extinguishers. Combustion produces phthalic anhydride and carbon oxides. 

CALCIUM CYANIDE or CALCIUM CYANIDE MIXTURE (592-01-8) Ca(CN)i Noncombustible solid. Contact with water, moist air, alcohols, acids, acid fume, and acid salts, or carbon dioxide, releases toxic and flammable hydrogen cyanide gas. Incompatible with oxidizers, fluorine, magnesium, nitrates, nitrites when heat is added, may cause fire and explosions. Thermal decoir osition above 662°F/350°C, releasing toxic nitrogen oxides and flammable hydrogen cyanide fumes. On small fires. Do not use COj. 

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