Hydroxyzine hydrochloride

Chemical Name 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]ethanol hydrochloride 

Trade Name Manufacturer Country Year Introduced 

N-Mono-1-p-chlorobenzohydrylpiperazine 1-Chloro-2-(2+iydroxyethoxy)ethane Sodium hydroxide Hydrogen chloride 

A mixture of 0.1 mol of N-mono-1-p-chlorobenzohydrylpiperazine and 0.1 mol of 1-chloro-2-(2-hydroxy-ethoxy)-ethane is heated for 3 hours to IBO C. The mass is then taken up in 100 ml of benzene and 100 ml of a 10% aqueous solution of NaOH decanting takes place, and the benzene solution is washed with water and the solvent is evaporated. Vacuum distilling of the residue yields 1-p-chlorobenzohydryl-4-[2-(2-hydroxy-ethoxy)-ethyl]-piperazine, BP 220°C/0.5 mm Hg. 

The corresponding dihydrochloride is prepared by dissolving this base in about twice its weight of alcohol, by treating it with excess of gaseous HCI and by precipitating it with ether. The solvent is decanted and the residue, dissolved in a minimum of alcohol, crystallizes on the addition of ether, MP 193°C, 

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HYDROXYZINE HYDROCHLORIDE TABLETS USP 25MG 600 TABLETS/BOTTLE 6605005799717 BT 12.55 ... 

Hydroxyzine hydrochloride Atarax, Vistarit) is the antihistamine with the greatest use in the treatment of anxiety. It is often used to reduce the anxiety that is associated with anesthesia and surgery. It also produces sedation, dries mucous membranes (via an anticholinergic mechanism), and has antiemetic activity. A more extensive discussion of the pharmacology of the Hj-receptor antagonists is found in Chapter 38. 

Antihistamines dimenhydrinate hydroxyzine hydrochloride promethazine hydrochloride... 

Piperazine derivatives cetirizine hydrochloride cyclizine lactate hydroxyzine hydrochloride meclizine hydrochloride... 

G. N. Menon and B. J. Norris, Simultaneous determination of hydroxyzine hydrochloride and benzyl alcohol in injection solutions by HPLC, J. Pharm. Sci., 70 691 (1981). 

Amifostine Amifostine is incompatible with many drugs such as acyclovir sodium, amphotericin, cefoperazone sodium, hydroxyzine hydrochloride, miconazole, minocycline hydrochloride, and prochlorpherazine edisylate.239 Care should be exercised when handling amyl nitrate, since it is highly flammable. Volatile nitrites, such as poppers, are abused and fatal adverse effects are reported.240,241... 

A 44-year-old man with depression was given hydroxyzine hydrochloride 100 mg/day, clonazepam 2 mg/ day, and citalopram 20 mg/day. Two years before he had tolerated fluoxetine for 6 months for an episode of depression, with good effect. After 7 weeks he developed weakness and weight loss. Physical examination was normal but the serum aspartate transaminase (AsT) was raised at 277 IU/L (reference range < 36 IU/1). His bilirubin was normal. Citalopram was withdrawn and the other drugs were continued intermittently 5 days later the serum aspartate transaminase had fallen by a half, and within 2 months it had returned to normal. 

Ridout F, Shamsi Z, Meadows R, Johnson S, Hindmarch I. A single-center, randomised, double-blind, placebo-con-trolled, crossover investigation of the effects of fexofenadine hydrochloride 180 mg alone and with alcohol, with hydroxyzine hydrochloride 50 mg as a positive internal control, on aspects of cognitive and psychomotor function related to driving a car. Clin Ther 2003 25 1518-38. 

Benzthiazide Clidinium Bromide 447.8 Tripelennamine Citrate Hydroxyzine Hydrochloride 469.5 470.0 Methysergide Maleate Dimenhydrinate... 

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