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Ethyol - Amifostine

The activity of sulfur towards platinum complexes has led to investigation of so-called rescue agents to ameliorate the side effects of platinum therapy, without compromising its anti-tumor activity. These nucleophilic sulfur compounds include sodium thiosulfate (STS), sodium diethyldithio-carbamate (Naddtc), (S)- 2-[(3-aminopropyl)amino]ethyl phosphorothioic acid (WR-2721, Ethyol , amifostine), glutathione (GSH), methionine, thiourea, cysteine, -acetylcysteine, penicillamine, biotin, sulfathiazole, sodium 2-mercaptoethanesulfonate (mesna), and its dimer (di)mesna (BNP-7787). The protective effect of these compounds is either due to prevention, or reversal of Pt-S adducts in proteins. Some of the more promising of the above-mentioned compounds (see Fig. 1) will be discussed below. [Pg.344]

An informative case exists in the literature of a phosphorothioic S-acid ester. Indeed, amifostine (ethyol, WR-2721, 9.63) is a phosphorothioate first... [Pg.584]

Acetylcysteine (Aceta-dote, Mucomyst) Albuterol (Proventil, Ventolin, Volmax) Amifostine (Ethyol) Atropine (AtroPen) Atropine/Pralidoxime (DuoDote)... [Pg.33]

See other pages where Ethyol - Amifostine is mentioned: [Pg.604]    [Pg.346]    [Pg.116]    [Pg.652]    [Pg.266]    [Pg.604]    [Pg.346]    [Pg.116]    [Pg.652]    [Pg.266]    [Pg.185]    [Pg.71]    [Pg.13]    [Pg.634]    [Pg.652]    [Pg.292]    [Pg.61]    [Pg.868]   


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Amifostine

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