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Natural products syntheses

The cyclization to form very congested quaternary carbon centers involving the intramolecular insertion of di-, tri-, and tetrasubstituted alkenes is particularly useful for natural products synthesis[l36-138], In the total synthesis of gelsemine, the cyclization of 166 has been carried out, in which very severe steric hindrance is e.xpected. Interestingly, one stereoisomer 167... [Pg.152]

Cleavage of silyloxiranes (e.g. 55) by methanol, leading to aldehydes or ketones (e.g. 56 Scheme 48), has found use in natural products synthesis (8UA1831, 80JA5004). [Pg.110]

Oxirane opening by functionalized ethenylaluminum (81JA1851) and ethenylcopper (79JCS(Pl)2954) reagents has found applications in natural products synthesis. [Pg.112]

The Boekelheide reaction has found utility in a number of synthetic applications. A notable example of its application to natural product synthesis was described by... [Pg.343]

In the realm of natural product synthesis, Kepler and Rehder utilized the K-R reaction to synthesize ( )-calanolide A (56), a potent non-nucleosidal human irmnunodeficiency virus (HIV-1) specific reverse transcriptase inhibitor. Propiophenone 57 was allowed to react with acetic anhydride in the presence of sodium acetate to afford benzopyranone 58 in 56% yield subsequent deacetylation of 58 gave 59. Flavone 59 was then transformed to ( ) calanolide A (56) over several steps. [Pg.529]

Over the years the venerable K-R reaction has been instrumental in constructing flavones for SAR programs and natural product synthesis. ... [Pg.530]

The final chapter in this volume by R. Kumar and R. Chandra (University of Delhi, India) deals with stereocontrolled additions to di- and tetrahydropyridines and particularly their application to natural product synthesis. [Pg.316]

Novel indole synthesis and its application to natural product synthesis 98JHC1043. [Pg.225]

Chemoselective reduction of a,(3-epoxy carbonyl compounds to aldols and their analogs by organoseleniums and its application to natural product synthesis 98YGK736. [Pg.243]

The results obtained showed that carbon, oxygen, or nitrogen functionalities are readily introduced into the a,p positions of the lactone moiety. In this way, useful precursors for natural product synthesis are accessible (88TL5317). [Pg.146]

The condensation reaction of a CH-acidic compound—e.g. a ketone 3—with formaldehyde 1 and ammonia 2 is called the Mannich reaction, the reaction products 4 are called Mannich bases. The latter are versatile building blocks in organic synthesis, and of particular importance in natural products synthesis. [Pg.194]

The Neber rearrangement has for example found application in natural product synthesis. [Pg.209]

The intramolecular Sakurai reaction allows for the synthesis of functionalized bicyclic systems. By proper choice of the reaction conditions, especially of the Lewis acid or fluoride reagent used, high stereoselectivity can be achieved, which is an important aspect for its applicability in natural products synthesis. [Pg.247]

The Sharpless epoxidation is one of the most important of the newer organic reactions. Although limited to allylic alcohols, it has found wide application in natural product synthesis. [Pg.256]

Natural product synthesis poses the challenge to consider and develop new pathways of structural transformation. Natural products as targets for synthetic research possess a special fertility in this regard, because the structural channels of biosynthesis are not necessarily the conduits of organic synthesis. A. Eschenmoser19... [Pg.9]

Nicolaou, K.C. Petasis, N. A. Selenium in Natural Products Synthesis, CIS Philadelphia, 1984. [Pg.418]

Mori et al. have demonstrated the most dramatic uses of lithiated epoxides in natural product synthesis [62]. By employing the chemistry developed by Jackson, and subsequently performing a Lewis acid-catalyzed (BF3 OEt2) cyclisation, tetra-hydrofuran, tetrahydropyran, and oxepane rings are readily accessed this strategy is demonstrated by the synthesis of the marine epoxy lipid 173 (Scheme 5.40) [63]. [Pg.165]

Some more complex examples of this reaction type from the field of natural product synthesis, using a ketone, a thioenol ether, or a phenyl function as an internal nucleophile, are found in references 171-173. [Pg.852]

Natural products, synthesis of 829, 835, 837, 840-842, 948, 958 Nitrile oxides, reactions of 807 Nitriles - see also y-Ketonitriles reactions of 277 synthesis of 815 Nitrilimines, reactions of 277 Nitritosulphonium intermediates 206 Nitrogen compounds, as oxidizing agents 970-972... [Pg.1202]

Diene, Enyne, and Diyne Metathesis in Natural Product Synthesis... [Pg.269]


See other pages where Natural products syntheses is mentioned: [Pg.27]    [Pg.27]    [Pg.16]    [Pg.362]    [Pg.6]    [Pg.113]    [Pg.244]    [Pg.382]    [Pg.476]    [Pg.250]    [Pg.9]    [Pg.156]    [Pg.296]    [Pg.2]    [Pg.341]    [Pg.382]    [Pg.485]    [Pg.631]    [Pg.151]    [Pg.479]    [Pg.512]    [Pg.240]    [Pg.243]    [Pg.271]    [Pg.272]    [Pg.273]   
See also in sourсe #XX -- [ Pg.829 , Pg.835 , Pg.837 , Pg.840 , Pg.841 , Pg.948 , Pg.958 ]

See also in sourсe #XX -- [ Pg.478 ]

See also in sourсe #XX -- [ Pg.478 ]

See also in sourсe #XX -- [ Pg.263 ]

See also in sourсe #XX -- [ Pg.938 , Pg.939 , Pg.940 ]

See also in sourсe #XX -- [ Pg.2 , Pg.187 ]

See also in sourсe #XX -- [ Pg.2 , Pg.187 ]




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Acylpalladation natural product synthesis

Aims of Natural Product Synthesis, Changes over Time

Aldolase Antibody-catalyzed Reactions in Natural Product Synthesis

Alkaloid natural product synthesis

Alkene metathesis natural product synthesis

Alkenes natural product synthesis

Alkenyl-aryl coupling natural product synthesis

Alkenyl-aryl cross-coupling natural products synthesis

Alkyl derivatives natural product synthesis applications

Alkyl derivatives natural products synthesis

Alkylation natural product synthesis

Alkyne derivatives natural products synthesis

Alkynylation natural product synthesis

Allylic derivatives natural products synthesis

Allylic hydroperoxides natural product synthesis

Aluminum compounds natural products synthesis

An Application to Natural Products Synthesis Sterpurene

Aniline derivatives natural product synthesis

Annulation reactions natural products synthesis

Application in Biologically Interesting and Natural Product Syntheses

Application in Synthesis of Natural Products

Application in the Synthesis of Natural Products

Application of Organocatalytic Cascade Reactions in Natural Product Synthesis and Drug Discovery

Application to the Synthesis of Natural Products

Applications in Natural Product Syntheses

Applications natural product synthesis

Applications of Palladium and Nickel Complexes in Natural Product Synthesis

Applications to Natural Product Synthesis

Aromatic natural products biomimetic synthesis

Asymmetric epoxidation natural products synthesis

Asymmetric reactions carbopalladation, natural products synthesis

Aza-Wittig Reaction in Natural Product Syntheses

Azides natural product synthesis

Aziridine intermediates, synthesis of natural products via

Benzyl derivatives natural products synthesis

Benzylation reactions natural products synthesis

Bicyclic compounds natural products synthesis

Bioactive natural products chiral synthesis

Biomimetic chemistry natural product synthesis

Boron compounds natural products synthesis

Br0nsted Acid-Catalyzed Cascade Reactions in Natural Product Synthesis

Bronsted natural products synthesis

Bryostatin natural products, synthesis

Butyrolactone natural products synthesis

Carbohydrates natural products, syntheses

Carbon nucleophiles natural products synthesis

Carbonyl compounds natural products synthesis

Carbonylation natural product synthesis

Cascade Metathesis in Natural Product Synthesis

Cascade reactions in natural product synthesis

Cascade reactions natural products synthesis

Case Studies in Natural Products Total Synthesis

Catalysis continued natural product synthesis

Catalytic Enantioselective Olefin Metathesis and Natural Product Synthesis

Catch-release, asymmetric, natural product synthesis

Chiral natural products synthesis

Cinchona natural products synthesis

Complementary Aspects of Natural Product Syntheses by Tandem-Domino Reactions and MCR Chemistry

Conjugate reduction natural products synthesis

Conjugate substitution natural products synthesis

Copper-Mediated Synthesis of Natural and Unnatural Products

Coupling natural products synthesis

Cross-coupling reactions natural product synthesis

Cross-metathesis in Natural Products Synthesis

Cycle-Specific Cascade Catalysis in Natural Product Synthesis

Cyclization natural products synthesis

Cycloaddition reactions natural products synthesis, cyclizations

Cyclopentanes natural products synthesis, cyclizations

Dihydroxyacetone natural product synthesis

Diversity-oriented Synthesis of Natural-product-like Libraries

Domino Reactions in the Total Synthesis of Natural Products

Domino cyclization natural products synthesis

Dotz natural product synthesis

Double bonds natural product synthesis

Drug synthesis natural product compounds

Electrophilic reactions natural products synthesis

Enamines natural product synthesis, carbon nucleophile

Enantioselectivity natural product synthesis

Endo cyclization natural products synthesis

Enolate compounds natural product synthesis applications

Enolate compounds natural products synthesis

Enolates natural product synthesis

Epoxides natural products synthesis

Esterases as User-Friendly Biocatalysts in Natural Product Synthesis

Examples of Relay Metathesis Motivated by Natural Product Synthesis

Favorskii rearrangement, natural product synthesis

Hajos-Parrish reaction natural product synthesis

Heck reaction natural products synthesis

Hetero Diels-Alder cycloaddition reactions synthesis of natural heterocyclic products

Heteroaromatics natural products synthesis

Heterocyclic products, natural, synthesis

Heterocyclic products, natural, synthesis by hetero Diels-Alder cycloaddition

Heterocyclic products, natural, synthesis hetero Diels-Alder cycloaddition reactions

Heterocyclic products, natural, synthesis of by hetero Diels-Alder cycloaddition

Heterocyclic products, natural, synthesis reactions

Highlights in Total Synthesis of Natural Products

Homoallylic derivatives natural products synthesis

Homocoupling reactions natural product synthesis

Horner-Wadsworth-Emmons reaction natural product synthesis

Hydrogenation drug/natural product synthesis

Iminium-Ion-Catalyzed Cascade Reactions in Natural Product Synthesis

In Natural Product Synthesis

Indole Ring Synthesis: From Natural Products to Drug Discovery, First Edition. Gordon W. Gribble

Ireland-Claisen rearrangement natural product synthesis

Larock indole synthesis natural products

M. Waser, Asymmetric Organocatalysis in Natural Product Syntheses

MBFTs for the Total Synthesis of Natural Products

Magnesium compounds natural products synthesis

Marine natural products, syntheses including

Meso intermediates, natural products synthesis

Metal enolates natural products synthesis

Metathesis in Natural Product Synthesis: Strategies, Substrates and Catalysts. Edited by Janine Cossy

Metathesis natural product synthesis

Microwave irradiation natural product synthesis

Modem organic synthesis complex natural products

Modern organic synthesis complex natural products

Multicomponent Reactions in the Total Synthesis of Natural Products

Multistep Use of Supported Reagents in Natural Product Synthesis

Natural Product Synthesis using Grubbs Metathesis Lasubine II

Natural Product Synthesis via Titanium Enolate Aldol Reactions

Natural Product and Bioactive Compound Synthesis

Natural Products Synthesis and Pesticide Science

Natural Products as an Inspiration for the Discovery of New High-Throughput Chemical Synthesis Tools

Natural heterocyclic products by hetero synthesis

Natural product libraries synthesis

Natural product synthesis 1.2- stereogenic centers

Natural product synthesis 3 + 2] cyclizations

Natural product synthesis Agelastatin

Natural product synthesis Amphidinolide

Natural product synthesis Cyanthiwigin

Natural product synthesis Ephedradine

Natural product synthesis Ingenol

Natural product synthesis Lasubine

Natural product synthesis Lepadin

Natural product synthesis Ophirin

Natural product synthesis Phenserine

Natural product synthesis Podophyllotoxin

Natural product synthesis Quinidine

Natural product synthesis Quinine

Natural product synthesis Reaction

Natural product synthesis Robinson annulation

Natural product synthesis Spiculoic Acid

Natural product synthesis Spirotryprostatin

Natural product synthesis Strychnine

Natural product synthesis Tetracyclin

Natural product synthesis Tetrodotoxin

Natural product synthesis Tocopherol

Natural product synthesis Vindoline

Natural product synthesis Yohimbine

Natural product synthesis Zaragozic Acid

Natural product synthesis allyl acetate

Natural product synthesis amination reactions

Natural product synthesis aryl/vinyl halides

Natural product synthesis carbon nucleophile cyclization

Natural product synthesis carbopalladation

Natural product synthesis cascade carbopalladation

Natural product synthesis derivatives

Natural product synthesis desymmetrization

Natural product synthesis disparlure

Natural product synthesis enantiopure intermediate

Natural product synthesis enol triflates

Natural product synthesis five-membered ring compounds

Natural product synthesis four-membered ring formation

Natural product synthesis frontalin

Natural product synthesis ketones

Natural product synthesis large biologically active compounds

Natural product synthesis large ring formations

Natural product synthesis linalool

Natural product synthesis miscellaneous compounds

Natural product synthesis moiety

Natural product synthesis nucleophilic substitution

Natural product synthesis organic electrophiles

Natural product synthesis organometals

Natural product synthesis oxygen nucleophile cyclization

Natural product synthesis palladium-catalyzed allylation

Natural product synthesis panaxytriol

Natural product synthesis preparation

Natural product synthesis prostaglandin derivatives

Natural product synthesis racemic alcohols, kinetic resolution

Natural product synthesis reduction

Natural product synthesis single stereogenic center

Natural product synthesis three-member ring compounds

Natural product synthesis transmetallation

Natural product synthesis via aziridines

Natural product synthesis, ring structures

Natural product synthesis, ring structures 3 + 2] cyclization

Natural product synthesis, ring structures 3 + 2] cyclizations

Natural product synthesis, ring structures moiety

Natural product total synthesis

Natural products asymmetric synthesis

Natural products biomimetic synthesis

Natural products catalytic enantioselective synthesis

Natural products chemical synthesis

Natural products combinatorial synthesis,

Natural products fluorous mixture synthesis

Natural products photooxygenation synthesis

Natural products solid phase syntheses

Natural products stereoselective synthesis

Natural products synthesis 3-hetero-substituted organic electrophiles

Natural products synthesis asymmetric Heck reaction

Natural products synthesis asymmetric properties

Natural products synthesis asymmetric reactions

Natural products synthesis basic principles

Natural products synthesis domino reactions

Natural products synthesis double bond migration

Natural products synthesis endo reactions

Natural products synthesis enyne cycloisomerization

Natural products synthesis intermolecular reactions

Natural products synthesis intramolecular reactions

Natural products synthesis macrocyclic reactions

Natural products synthesis research background

Natural products synthesis vinylic substitution

Natural products synthesis, strained alkenes

Natural products total synthesis" publications

Natural products, synthesis Diels-Alder reaction

Natural products, synthesis Mannich reaction

Natural products, synthesis via aziridine

Natural products, synthesis via aziridine intermediates

Neber rearrangement natural product synthesis

New Methods for the Synthesis of Polyketide Derived Natural Products

Nickel natural product synthesis

Nickel-catalyzed reactions natural products synthesis

Nitrogen nucleophiles natural products synthesis

Olefin metathesis natural product synthesis

Olefins diene natural product synthesis

Olefins natural product synthesis

Organic Synthesis Challenging Natural Products and New Frontiers

Organic Synthesis via Examination of Selected Natural Products

Organometallic compounds natural product synthesis

Organotin natural product synthesis

Oxidation reactions, transition-metal natural products synthesis

Oxidative rearrangements natural product synthesis

Oxygen nucleophiles natural products synthesis

Palladium natural product synthesis

Palladium®) complexes carbonylation, natural products synthesis

Palladium®) salts natural products synthesis

Partial Synthesis of Natural Products

Pictet natural products synthesis

RECENT ADVANCES IN SOLID-PHASE SYNTHESIS OF NATURAL PRODUCTS

Radical chemistry natural product synthesis

Rearrangement natural products synthesis

Ring closing metathesis natural product synthesis

Ring contraction, natural product synthesis

Ring systems natural products synthesis

Ruthenium natural products, syntheses

Sandmeyer reaction natural product synthesis

Scavengers natural product synthesis

Schliiter and Zhishan Bo 18 Synthesis of Natural Products via Palladium-Catalyzed ross-Coupling

Selected Applications of Achiral Type II Allylmetal Reagents in Natural Product Synthesis

Selected Applications of the Catalytic Enantioselective Allylation Reaction in Natural Product Synthesis

Sharpless asymmetric epoxidation natural products synthesis

Shengming Ma 8 Synthesis of Natural Products via Carbopalladation

Silver catalysts natural product synthesis

Solid natural product synthesis using

Solid natural products synthesis

Solid-phase Target-Oriented Total Synthesis of Natural Products

Solid-phase organic synthesis natural products

Spiroketals in Natural Product Synthesis

Stereoselective Aldol Reactions in the Synthesis of Polyketide Natural Products

Stereoselective synthesis halogenated natural products

Stereoselective synthesis of natural products

Steroids, natural products synthesis, carbon

Steroids, natural products synthesis, carbon reactions

Stille Cross-Coupling for the Synthesis of Natural Products

Subject natural product synthesis

Substitution reactions, natural products synthesis

Syntheses of Heterocycles, Natural Products, and Other Biologically Active Compounds Applying Heck Reactions

Syntheses of natural products and biologically active compounds

Synthesis complex natural product

Synthesis of Bioactive Natural Products

Synthesis of Diquinane Natural Products

Synthesis of Glycosylated Natural Products

Synthesis of Glycosylated Natural Products and Their Analogues

Synthesis of Heterocyclic Natural Products (-)-Ephedradine

Synthesis of Natural Products and Pharmaceuticals via Catalytic C-H Functionalization

Synthesis of Natural Products and Related Compounds Using Ene-Yne Metathesis

Synthesis of Natural Products in an Efficient Manner

Synthesis of Non-Natural Products

Synthesis of Oxacyclic Natural Products

Synthesis of Triquinane Natural Products

Synthesis of complex natural products

Synthesis of natural heterocyclic products

Synthesis of natural heterocyclic products by hetero

Synthesis of natural heterocyclic products by hetero Diels-Alder cycloaddition reactions

Synthesis of natural products

Synthesis of thiazole-containing natural products

Synthesis ofthe Natural Product

Synthesis polyhydroxylated natural products

Synthesis, and natural products

Tandem reactions natural products synthesis

Temporary Silicon-Tethered Ring-Closing Metathesis Reactions in Natural Product Synthesis

Tetrahydropyrans synthesis natural products

The Asymmetric Intramolecular Mizoroki-Heck Reaction in Natural Product Total Synthesis

The synthesis of non-racemic natural products

Thioesters natural product synthesis

Thiourea natural products synthesis

Tin compounds natural products synthesis

Total Synthesis of Natural Products, Vols

Total syntheses of natural products

Transannular cyclization natural product synthesis

Transannular natural product synthesis

Transannular natural product synthesis Diels-Alder reaction

Transannular natural product synthesis cycloaddition reactions

Transition metal catalysts natural products synthesis

Transition-Metal-Catalyzed Stereoselective Oxidations in Drug and Natural Product Synthesis

Tricyclic natural products synthesis

Triumphs in the Synthesis of Unnatural and Natural Products

Use in Natural Product Synthesis

Use of Transition Metal-Catalyzed Cascade Reactions in Natural Product Synthesis and Drug Discovery

Vinyl halides natural products synthesis

Wacker process natural products synthesis

Wacker-Type Oxidations in Natural Products Synthesis

Zinc compounds natural products synthesis

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