Bronsted natural products synthesis

Mat Robinson was born in Malvern he graduated from the University of Wales Swansea with a first class M.Chem. degree in 2004. He is also currently studying there for his Ph.D. under the supervision of Dr. Andy Graham. His research interests include the development of novel solid Lewis and Bronsted acids, nanomaterials, and rearrangement reactions in natural product synthesis. 

Netherton and Fu [46] recommended the conversion of air-sensitive triphe-nylphosphines to their phosphonium salts (e.g., by the addition of HBF4) the phosphine is liberated in situ by a Bronsted base under the reaction conditions. Liebeskind et al. [47] introduced Ph2P02NBu4 as the so-called tin scavenger it has since been employed by other groups [48, 49] for intramolecular vinyl/vinyl coupling in natural product synthesis (see later discussion). 

Quinoline derivatives are of wide occurrence in natural products and medicinal drugs they also find applications in polymer chemistry, electronics, and optoelectronics for their excellent mechanical properties as well [200]. The Friedlander synthesis of quinolines is a classic method involving reduction of o-nitro aryl aldehyde as the first step followed by condensation of the reduced product with enolizable carbonyl compound in the presence of a Bronsted or Lewis acid catalyst [201]. To avoid the harsh reaction conditions, the use of ILs has recently gained considerable attention in the synthesis of quinoline derivatives. 

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