Aza-Wittig Reaction in Natural Product Syntheses

Francisco Palacios, Concepcion Alonso, Domitila Aparicio, Gloria Rubiales and Jesus M. de los Santos 

Departamento de Qutmica Orgdnica I, Facultad de Farmacia, Universidad del Pais Vasco. Apartado 450. 01080 Vitoria, Spain 

Since then, the Wittig and aza-Wittig reactions have undergone tremendous development and have become a powerful tool in organic synthetic strategies directed towards the construction of acyclic and cyclic compounds, mainly because the reaction is conducted in neutral solvents in the absence of catalysts, generally at mild temperatures, and usually proceeds high yields. 

Numerous research papers and several reviews have appeared describing the general use of phosphazenes as reagents and intermediates in organic synthesis. This account describes the use of the aza-Wittig reaction for the preparation of natural products by means of intermolecular and intramolecular processes. Despite the aza-Wittig strategy 

Organic Azides Syntheses and Applications Edited by Stefan Erase and Klaus Banert 2010 John Wiley Sons, Ltd. ISBN 978-0-470-51998-1 

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