Hydrogenation drug/natural product synthesis

STEREOSELECTIVE HYDROGENATION OF C = C BONDS APPLICATION TO DRUG AND NATURAL PRODUCT SYNTHESIS... 

Rh-Catalyzed Hydrogenation to Drug and Natural Product Synthesis... 

The diversity requirement of chiral amines in the synthesis of natural products and chiral drugs is everlasting and the most studies about the catalytic asymmetric hydrogenation of enamines have dealt with simple substrates to date. Hence, it is necessary to explore highly efficient enantioselective protocol to provide more complex and also industrially useful chiral amines. We are confident that the easily accessible and changeable monodentate phosphorus hgands will find a wide appli cation in this field. 

Two efficient processes for the synthesis of rivastigmine, one of the potent drugs for the treatment of Alzheimer s disease, have been developed for industrial applications with Ir-(5)-28a-catalyzed asymmetric hydrogenation as the key step [70]. Additionally, the Ir-28a-catalyzed asymmetric hydrogenation of ketones was also used as a key step in the synthesis of natural products of (-)-mesembrine [71] and (-)-centrolobine [72]. 

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